Superiority |
|
|
|
|
Rizoli6262 Rizoli SB, Rhind SG, Shek PN, Inaba K, Filips D, Tien H, et al. The immunomodulatory effects of hypertonic saline resuscitation in patients sustaining traumatic hemorrhagic shock: a randomized, controlled, double-blinded trial. Ann Surg. 2006;243(1):47-57.
|
27 |
HSD |
NS |
Hemorrhage/immune response |
Junger6363 Junger WG, Rhind SG, Rizoli SB, Cuschieri J, Shiu MY, Baker AJ, et al. Resuscitation of traumatic hemorrhagic shock patients with hypertonic saline-without dextran-inhibits neutrophil and endothelial cell activation. Shock. 2012;38(4):341-50.
|
34 |
HS/HSD |
NS |
Hemorrhage/immune response |
Bulger6464 Bulger EM, Cuschieri J, Warner K, Maier RV. Hypertonic resuscitation modulates the inflammatory response in patients with traumatic hemorrhagic shock. Ann Surg. 2007;245(4):635-41.
|
62 |
HSD |
NS |
Hemorrhage/immune response |
Yildizdas6565 Yildizdas D, Altunbasak S, Celik U, Herguner O. Hypertonic saline treatment in children with cerebral edema. Indian Pediatr. 2006;43(9):771-9.
|
67 |
HS |
mannitol |
pediatric cerebral edema/intracranial pressure |
Schroth6666 Schroth M, Plank C, Meissner U, Eberle KP, Weyand M, Cesnjevar R, et al. Hypertonic-hyperoncotic solutions improve cardiac function in children after open-heart surgery. Pediatrics. 2006;118(1):e76-84.
|
50 |
HSH |
NS |
pediatric open heart surgery |
Equivalence |
|
|
|
|
Bulger6767 Bulger EM, Jurkovich GJ, Nathens AB, Copass MK, Hanson S, Cooper C, et al. Hypertonic resuscitation of hypovolemic shock after blunt trauma: a randomized controlled trial. Arch Surg. 2008;143(2):139-48,
|
209 |
HSD |
LR |
Blunt trauma & hypotension/ARDSfree at 28 days |
Bulger6868 Bulger EM, May S, Brasel KJ, Schreiber M, Kerby JD, Tisherman SA, et al. Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial. JAMA. 2010;304(13):1455-64.
|
1331 |
HS/HSD |
NS |
Head Injury/Brain deficit at 6 months |
Bulger6969 Bulger EM, May S, Kerby JD, Emerson S, Stiell IG, Schreiber MA, et al. Out-of-hospital hypertonic resuscitation after traumatic hypovolemic shock: a randomized, placebo controlled trial. Ann Surg. 2011;253(3):431-41.
|
853 |
HS/HSD |
NS |
Hemorrhage/Survival at 28 days |
Fang7070 Fang ZX, Li YF, Zhou XQ, Zhang Z, Zhang JS, Xia HM, et al. Effects of resuscitation with crystalloid fluids on cardiac function in patients with severe sepsis. BMC Infect Dis. 2008;8:50.
|
94 |
HS/HCO3
|
NS |
Sepsis & Hypotension/Survival |