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Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis

Abstract

The authors investigated the relation between parasites and host-cells in active and regressed lesions of a patient with diffuse cutaneous leishmaniasis, evaluating the frequency of different cell types, and the location and integrity of amastigotes. No correlation was found between parasite integrity and size of parasitophorous vacuoles. They observed ultrastructural findings characterizing a cell mediated immune response: macrophages lysis, parasitic destruction inside macrophages, close contact between parasitized macrophages and lymphocytes and between parasites and lymphocytes, lymphocytic infiltration and fibrosis. They suggest that in DCL there is a limited cellular immune response, although insufficient to control infection.

diffuse cutaneous leishmaniasis; human leishmaniasis; Leishmania; skin biopsie


ABSTRACT

Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis

Achilea Lisboa Bittencourt1

Luiz Antonio Rodrigues de Freitas2

Margarida L. Pompeu3

Maria Lucia Vieira4

Aldina Barral5

UFBa, Hosp. Univ. Prof. Edgard Santos, Departamento de Anatomia Patológica, Salvador, Brasil

Centro de Gonçalo Muniz, Salvador, Brasil

UFCe, Departamento de Patologia, Salvador, Brasil

Centro de Pesquisa Gonçalo Muniz, Hosp. Prof. Edgard Santos, Laboratório de Imunologia, Salvador, Brasil

UFBa, Hosp. Prof. Edgard Santos, Laboratório de Imunologia, Salvador, Brasil

The authors investigated the relation between parasites and host-cells in active and regressed lesions of a patient with diffuse cutaneous leishmaniasis, evaluating the frequency of different cell types, and the location and integrity of amastigotes. No correlation was found between parasite integrity and size of parasitophorous vacuoles. They observed ultrastructural findings characterizing a cell mediated immune response: macrophages lysis, parasitic destruction inside macrophages, close contact between parasitized macrophages and lymphocytes and between parasites and lymphocytes, lymphocytic infiltration and fibrosis. They suggest that in DCL there is a limited cellular immune response, although insufficient to control infection.

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Publication Dates

  • Publication in this collection
    24 June 2009
  • Date of issue
    Mar 1990
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