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Toxicological and toxicogenetic effects of plants used in popular medicine and in cattle food

Abstract

Toxicological and toxicogenetic effects of aqueous (tea) and hexanica fruit extract of Indigofera suffruticosa Mill, and hydroalcoholic root extract od Solanum agrarium Stendt. Were evaluated in Balb C male mice intraperitoneally exposed. A hepatotoxic effect was observed just for animals treated with aqueous fruit extract of I. suffruticosa. In relation to the toxicogenetic effect, just the group trreated with 12.5% of toxic dose of aqueous fruit extract of I. suffruticosa showed a statistically significant increase in the frequency of cells with chromosome aberrations (cytogenetic effect), although a slight increase was also observed for the highest dose (25% of LF50_ of hydroalcoholic root extract of S. agrarium. The results obtanied show that before S. agrarium is used as medicine and before the wide use of I. suffruticosa in cattle food, careful evaluation must be done.

chromosome aberration; Indgofera suffruticosa; Solanum agrarium; poisonous plants


ABSTRACT

Toxicological and toxicogenetic effects of plants used in popular medicine and in cattle food

Lúcia R. Ribeiro1

Ana Rita P. L. Bautista2

Ana Rita Silva1

Liana A. Sales2

Daisy M. F. Salvadori1

Paulo C. Maia1

UFBA, Escola de Medicina Veterinária, Laboratório de Genética Toxicológica, Salvador, Brasil

Empresa de Pesquisa Agropecuária da Bahia, Salvador, Brasil

Toxicological and toxicogenetic effects of aqueous (tea) and hexanica fruit extract of Indigofera suffruticosa Mill, and hydroalcoholic root extract od Solanum agrarium Stendt. Were evaluated in Balb C male mice intraperitoneally exposed. A hepatotoxic effect was observed just for animals treated with aqueous fruit extract of I. suffruticosa. In relation to the toxicogenetic effect, just the group trreated with 12.5% of toxic dose of aqueous fruit extract of I. suffruticosa showed a statistically significant increase in the frequency of cells with chromosome aberrations (cytogenetic effect), although a slight increase was also observed for the highest dose (25% of LF50_ of hydroalcoholic root extract of S. agrarium. The results obtanied show that before S. agrarium is used as medicine and before the wide use of I. suffruticosa in cattle food, careful evaluation must be done.

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Publication Dates

  • Publication in this collection
    24 June 2009
  • Date of issue
    1991
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