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Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice

Abstract

Previous work in our laboratory, mainly foccused the prospects of achieving resistance against Schistosoma mansoni infection with adult worm-derived antigens in the form of a soluble extract (SE). This extract obtained by incubation of living adult schistosomes in saline, contains a large number of distinct molecules and was actually shown to be a significantly protective in different outbred animals models such as Swiss mice and rabbits. It thus appeared worthwile to investigate the potencial protective activity of SE in different inbred strains of mice, known to be highly susceptible to the infection. Herein we present data showing that DBA/2 mice, once immunized with SE acquire significant levels of resistance to a S. mansoni cercarial challenge. In addition, preliminary studies on the immune system of immunized animals reveled that, injection of SE caused no general inbalance of B or T cell responses.

vaccination; Schistosoma mansoni; murine model; antigens


ABSTRACT

Vaccination in murine schistosomiasis with adult worm derived antigens - II. Protective and immune response in inbred mice

Miriam Tendler1

Roberto Magalhães Pinto1

Antonio de Oliveira Lima2

Wilson Savino3

Naftale Katz4

Instituto Oswaldo Cruz, Departamento de Helmintologia, Rio de Janeiro, Brasil

Fundação Ataulpho de Paiva, Rio de Janeiro, Brasil

FIOCRUZ, Centro de Pesquisas René Rachou, Departamento de Imunologia, Belo Horizonte, Brazil

FIOCRUZ, Centro de Pesquisas René Rachou, Belo Horizonte, Brasil

Previous work in our laboratory, mainly foccused the prospects of achieving resistance against Schistosoma mansoni infection with adult worm-derived antigens in the form of a soluble extract (SE). This extract obtained by incubation of living adult schistosomes in saline, contains a large number of distinct molecules and was actually shown to be a significantly protective in different outbred animals models such as Swiss mice and rabbits. It thus appeared worthwile to investigate the potencial protective activity of SE in different inbred strains of mice, known to be highly susceptible to the infection. Herein we present data showing that DBA/2 mice, once immunized with SE acquire significant levels of resistance to a S. mansoni cercarial challenge. In addition, preliminary studies on the immune system of immunized animals reveled that, injection of SE caused no general inbalance of B or T cell responses.

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Publication Dates

  • Publication in this collection
    15 June 2009
  • Date of issue
    1992
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