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• Mem. Inst. Oswaldo Cruz 90 (2) • Apr 1995 • https://doi.org/10.1590/S0074-02761995000200022   copy

Vaccination against schistosomiasis and fascioliasis with the new recombinant antigen Sm14: potential basis of a multi-valent anti-helminth vaccine?

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Molecular cloning of components of protective antigenic preparations have suggested that related parasite fatty acid binding proteins could form the basis of the well documented protective, immune cross reactivity between the parasitic trematode worms Fasciola hepatica and Schistosoma mansoni. We have now confirmed the cross protective potential of parasite fatty acid binding proteins and suggest that it may be possible to produce a single vaccine that would be effective against at least two parasites, F. hepatica and S. mansoni of veterinary and human importance respectively.

schistosomiasis; fascioliasis; vaccines; fatty acid binding protein (FABP)

ABSTRACT

Vaccination against schistosomiasis and fascioliasis with the new recombinant antigen Sm14: potential basis of a multi-valent anti-helminth vaccine?

Miriam Tendler1

Monica Magno Vilar1

Cristiana Alves Brito2

Nicolau Maués da Serra Freire3

Naftale Katz4

Andrew Simpson5

Instituto Oswaldo Cruz, Departamento de Helmintologia, Laboratõrio de Esquistossomose Experimental, Rio de Janeiro, Brasil

FIOCRUZ, Centro de Pesquisas René Rachou, Laboratório de Biologia Moelecular, Rio de Janeiro, Brasil

Universidade Federal Rural do Rio de Janeiro, Brasil

FIOCRUZ, Centro de Pesquisas René Rachou, Laboratório de Biologia Molecular, Rio de Janeiro, Brasil

FIOCRUZ, Centro de Pesquisas René Rachou, Laboratório de Biologia Molecular, Belo Horizonte, Brasil

Molecular cloning of components of protective antigenic preparations have suggested that related parasite fatty acid binding proteins could form the basis of the well documented protective, immune cross reactivity between the parasitic trematode worms Fasciola hepatica and Schistosoma mansoni. We have now confirmed the cross protective potential of parasite fatty acid binding proteins and suggest that it may be possible to produce a single vaccine that would be effective against at least two parasites, F. hepatica and S. mansoni of veterinary and human importance respectively.

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Publication Dates

  • Publication in this collection
    01 June 2009
  • Date of issue
    Apr 1995
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