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Induction of synthesis of the rat cystatin S protein by the submandibular gland during the acute phase of experimental Chagas disease

Abstract

Rats experimentally infected with Trypanosoma cruzi Y strain exhibited hypertrophy of the submandibular gland at 18 days after infection.SDS-PAGE of infected rats saliva revealed the presence of an additional band with an apparent molecular weight of about 13KDa. Electrophoresis of protein salivaand immunochemical analysis with antibody against rat cystatin S confirmed that the protein was identical to that induced by beta adrenergic stimulation.

submandibular gland; Chagas disease; rat cistaten S


ABSTRACT

Induction of synthesis of the rat cystatin S protein by the submandibular gland during the acute phase of experimental Chagas disease

J. B. Alves1

M. S. D. Alves1

Y. Naito2

UFMG, IBC, Departamento de Morfologia, Belo Horizonte, Brasil

Nagoya City University, Faculty of Pharmaceutical Sciences, Dept. of Biological Chemistry, Nagoya, Japan

Rats experimentally infected with Trypanosoma cruzi Y strain exhibited hypertrophy of the submandibular gland at 18 days after infection.SDS-PAGE of infected rats saliva revealed the presence of an additional band with an apparent molecular weight of about 13KDa. Electrophoresis of protein salivaand immunochemical analysis with antibody against rat cystatin S confirmed that the protein was identical to that induced by beta adrenergic stimulation.

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Publication Dates

  • Publication in this collection
    01 June 2009
  • Date of issue
    Mar 1994
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