Schistosoma mansoni: structural damage after treatment with oxamniquine

Ageu Magalhães Filho Maria Eliane Bezerra de Melo Paulo Antônio Padovan Isairas Pereira Padovan About the authors

Abstract

The effects of a single dose (100 mg/kg-body weight of mouse) of oxamniquine on the worm's tegument and paranchyma in relation to the process of immunological granulomatous reaction of the host's liver are described under light and electron microscopy (EM). The lesions caused by the drug are sequentially and simultaneously described in form of swelling, surface bulble and disruption with erosions. Ulceration in the tubercules with loss of spines is often more extensive and severe in male worms and concentration of host's mononuclear cells is observed. The possible role of host's immune response is discussed.


ABSTRACT

Schistosoma mansoni: structural damage after treatment with oxamniquine

Ageu Magalhães Filho1

Maria Eliane Bezerra de Melo1

Paulo Antônio Padovan2

Isairas Pereira Padovan2

FIOCRUZ, Centro de Pesquisas Aggeu Magalhães, Recife, Brasil

UFPE, Laboratório de Imunopatologia, Recife, Brasil

The effects of a single dose (100 mg/kg-body weight of mouse) of oxamniquine on the worm's tegument and paranchyma in relation to the process of immunological granulomatous reaction of the host's liver are described under light and electron microscopy (EM). The lesions caused by the drug are sequentially and simultaneously described in form of swelling, surface bulble and disruption with erosions. Ulceration in the tubercules with loss of spines is often more extensive and severe in male worms and concentration of host's mononuclear cells is observed. The possible role of host's immune response is discussed.

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Publication Dates

  • Publication in this collection
    26 June 2009
  • Date of issue
    1987
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