The significance of variation in the susceptibility of Schistosoma mansoni to the antischistosomal drug oxamniquine

Abstract

Clinical and laboratory evidence is reviewed which shows that there is a great deal of variation in the susceptibility of Schistosoma mansoni to oxamniquine. This variation occurs both among endemic regions and within endemic regions in Brazil and Kenya. It is genetically controlled. It is suggested that the parasite possesses a large capacity for developing resistance to the drug and that resistance will develop where sufficient drug pressure is maintained.


ABSTRACT

The significance of variation in the susceptibility of Schistosoma mansoni to the antischistosomal drug oxamniquine

G. K. Kinoti1

University of Nairobi, Department of Zoology, Nairobi, Kenya

Clinical and laboratory evidence is reviewed which shows that there is a great deal of variation in the susceptibility of Schistosoma mansoni to oxamniquine. This variation occurs both among endemic regions and within endemic regions in Brazil and Kenya. It is genetically controlled. It is suggested that the parasite possesses a large capacity for developing resistance to the drug and that resistance will develop where sufficient drug pressure is maintained.

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

Publication Dates

  • Publication in this collection
    26 June 2009
  • Date of issue
    1987
Instituto Oswaldo Cruz, Ministério da Saúde Av. Brasil, 4365 - Pavilhão Mourisco, Manguinhos, 21040-900 Rio de Janeiro RJ Brazil, Tel.: (55 21) 2562-1222, Fax: (55 21) 2562 1220 - Rio de Janeiro - RJ - Brazil
E-mail: memorias@fiocruz.br