Transmission blocking immunity as observed in a feeder system and serological reactivity to Pfs 48/45 and Pfs230 in field sera

W. Roeffen T. Lensen B. Mulder K. Teelen R. Sauerwein W. Eling JHETh Meuwissen P. Beckers About the authors

Abstract

Monoclonal antibodies (mAbs) and human sera from gametocyte carriers were applied in the bio-assay to test for their transmission-blocking capacity. Competition ELISA's have been developed for the detection of natural transmission blocking antibodies. Approximately 55 of the sera blocking in the bio-assay gave positive results in these competition ELISA's.

Plasmodium falciparum; transmission; natural antibodies; competition ELISA's


ABSTRACT

Transmission blocking immunity as observed in a feeder system and serological reactivity to Pfs 48/45 and Pfs230 in field sera

W. Roeffen1

T. Lensen1

B. Mulder1

K. Teelen1

R. Sauerwein1

W. Eling1

JHETh Meuwissen1

P. Beckers1

University of Nijmegen, Department of Medical Microbiology, Holanda

Monoclonal antibodies (mAbs) and human sera from gametocyte carriers were applied in the bio-assay to test for their transmission-blocking capacity. Competition ELISA's have been developed for the detection of natural transmission blocking antibodies. Approximately 55 of the sera blocking in the bio-assay gave positive results in these competition ELISA's.

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Publication Dates

  • Publication in this collection
    15 June 2009
  • Date of issue
    1994
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