Abstract
Monoclonal antibodies (mAbs) and human sera from gametocyte carriers were applied in the bio-assay to test for their transmission-blocking capacity. Competition ELISA's have been developed for the detection of natural transmission blocking antibodies. Approximately 55 of the sera blocking in the bio-assay gave positive results in these competition ELISA's.
Plasmodium falciparum; transmission; natural antibodies; competition ELISA's
Transmission blocking immunity as observed in a feeder system and serological reactivity to Pfs 48/45 and Pfs230 in field sera
W. Roeffen1
T. Lensen1
B. Mulder1
K. Teelen1
R. Sauerwein1
W. Eling1
JHETh Meuwissen1
P. Beckers1
University of Nijmegen, Department of Medical Microbiology, Holanda
Monoclonal antibodies (mAbs) and human sera from gametocyte carriers were applied in the bio-assay to test for their transmission-blocking capacity. Competition ELISA's have been developed for the detection of natural transmission blocking antibodies. Approximately 55 of the sera blocking in the bio-assay gave positive results in these competition ELISA's.
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Publication Dates
-
Publication in this collection
15 June 2009 -
Date of issue
1994
