Trypanosomatidae codon usage and GC distribution

Guilhermina Alonso Palmira Guevara Jose L. Ramirez About the authors

Abstract

A study od Typanosomatidae GC distribution and codon usage is presented. The codon usage patterns in coincidence with the phylogenetical data are similar in Crithidia and Leishmania, whereas they are more divergent in Trypanosoma brucei and T. cruzi. The analyisis of the GC mutational pressure in these organisms reveals that T. brucei, and to a lesser extent T. cruzi, have envolved towards a more balanced use of all bases, whereas Leishmania and Crithidia retain features of a primeval genetic apparatus. Tables with approximated GC mutational pressure in homologous genes, and codon usage in Trypanosomatidae are presented.

Trypanosomatidae; codon usage; mutational pressure; GC content


ABSTRACT

Trypanosomatidae codon usage and GC distribution

Guilhermina Alonso1

Palmira Guevara1

Jose L. Ramirez1

Universidad Central de Venezuela, Centro de Biología Celular, Caracas, Venezuela

A study od Typanosomatidae GC distribution and codon usage is presented. The codon usage patterns in coincidence with the phylogenetical data are similar in Crithidia and Leishmania, whereas they are more divergent in Trypanosoma brucei and T. cruzi. The analyisis of the GC mutational pressure in these organisms reveals that T. brucei, and to a lesser extent T. cruzi, have envolved towards a more balanced use of all bases, whereas Leishmania and Crithidia retain features of a primeval genetic apparatus. Tables with approximated GC mutational pressure in homologous genes, and codon usage in Trypanosomatidae are presented.

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Publication Dates

  • Publication in this collection
    04 June 2009
  • Date of issue
    Dec 1992
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