Mass Variation Rate, in Acidic Environment, of Polyhydroxybutyrate and Chitosan matrices with Potential Application as Controlled Drug Delivery System

Abstract

Polymers such as the biocompatible polyhydroxybutyrate (PHB) and the polysaccharide chitosan (Chi), a pH-sensitive polymer, have been studied for drug delivery applications and scaffolds production. In this work, matrices of PHB and Chi were produced by compression molding (S_PHB-Chi) and loaded with a broad-spectrum biocide chlorhexidine (CHX) (S_PHB-Chi-CHX). The matrices were analyzed by scanning electron microscope (SEM). The S_PHB-Chi capacity to absorb and deliver CHX was evaluated by UV-Vis. The antibacterial activity of the samples against S. aureus, P. aeruginosa and E. coli (most common pathogens that cause infection in several body sites) was evaluated using the disk-agar diffusion method. The CHX release results were fitted by the Power Law model. The results suggested that the morphology and the CHX delivery profile were directly related to the Chi amount in the samples and also showed that the S_PHB-Chi-CHX is able to inhibit the microorganism proliferation, constituting it as a potential candidate for oral applications.

Keywords:
Modelling; S. aureus; P. aeruginosa; E. coli; Chlorhexidine