The subject of life meaning has been discussed since ancient times, and several works have been developed on its relation with other constructs, including values. Values contain universal and transcultural content but life meanings haven’t appeared, in the studies, as a goal to all cultures. According with the literature, the search for life meaning influences the values that guide human behaviors. Regarding the role that values play on the management of organizations, this study aimed to identify the difference between the life meanings of Brazilian and Portuguese managers. The research was exploratory descriptive and had used a quantitative method with a qualitative approach. The results highlighted the differences between life meanings of the two samples: the Brazilians being more guided by the self-achievement, and the Portuguese by the solidarity with the social groups that surround them