Soybean cultivar BRS 153, derived from the cross EMBRAPA 1 x Braxton, has medium cycle and has determinate growth habit plants, with white flowers, gray pubescence, and light brown hilum. It is resistant to soybean stem canker (Diaporthe phaseolorum f. sp. meridionalis), brown stem rot (Phialophora gregata), frogeye leafspot (Cercospora sojina), and powdery mildew (Microsphaera diffusa). In 19 environments of the State of Rio Grande do Sul, Brazil, BRS 153 averaged 12% and 14% higher yields than cultivars RS 7-Jacuí and BR-16, respectively. It is indicated for sowing in November in all regions of Rio Grande do Sul.