Efficacy of Resin Infiltration and Fluoride Casein Phosphopeptide Amorphous Calcium Phosphate Varnish on Non-cavitated Active White Spot Lesions in Children: A Randomized Clinical Trial

Dhamija, Mohit; Tyagi, Rish; Kalra, Namita; Khatri, Amit

doi:10.1590/pboci.2022.059

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Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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ORIGINAL ARTICLE • Pesqui. Bras. Odontopediatria Clín. Integr. 22 • 2022 • https://doi.org/10.1590/pboci.2022.059 copy

Efficacy of Resin Infiltration and Fluoride Casein Phosphopeptide Amorphous Calcium Phosphate Varnish on Non-cavitated Active White Spot Lesions in Children: A Randomized Clinical Trial

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Objective:

To compare the efficacy of resin infiltration and fluoride casein phosphopeptide amorphous calcium phosphate varnish on non-cavitated active white spot lesions in 5-8 years old children.

Material and Methods:

60 non-cavitated active white spot lesions in 60 patients with ICDAS II score 2 from both genders in the age range of 5 to 8 years were taken. Thirty lesions were treated by resin infiltration (Group 1) and 30 by Fluoride CPP-ACP varnish (Group 2). Resin infiltration was performed on the same day, while Fluoride CPP-ACP varnish was applied once a week for 4 weeks. The follow-up was done at 3, 6 months, and 12 months.

Results:

At 3, 6, and 12 months change in mean ICDAS II Score in group 1 was 1.5±0.5,1.13±0.73 and 0.9±0.88, respectively, while in group 2, it was observed to be 0.30±0.59, 0.4±0.89 and 0.06±0.82, respectively (p<0.001).

Conclusion:

Resin infiltration was more successful than Fluoride CCP-ACP varnish in active non-cavitated white spot lesions.

Keywords:
Dental Caries; Tooth, Deciduous; Fluorides; Preventive Dentistry

Gender	G1 (Resin Infiltration) N (%)	G2 (Fluoride CCP-ACP Varnish) N (%)
Male	14 (46.6)	19 (63.3)
Female	16 (53.3)	11 (36.6)
Total	30 (100.0)	30 (100.0)

Groups	Baseline Mean	3 Months Mean ± SD	6 Months Mean ± SD	12 Months Mean ± SD	p-value^b
Resin infiltration	2	0.5±0.S0	0.87±0.73	1.10±0.88	<0.001**
Fluoride CPP-ACP Varnish	2	1.70±0.59	1.60±0.89	1.93±0.82	<0.05*

Pairwise		p-value
Baseline	3 Months	<0.001**
	6 Months	<0.001**
	12 Months	<0.001**
3 Months	6 Months	<0.05*
	12 Months	<0.05*
6 Months	12 Months	<0.05*

Pairwise		p-value
Baseline	3 Months	>0.05
	6 Months	>0.05
	12 Months	>0.05
3 Months	6 Months	>0.05
	12 Months	>0.05
6 Months	12 Months	<0.05*

Clinical Status	Resin Infiltration N (%)	Fluoride CPP-ACP Varnish N (%)	p-value
Progressed to Cavitation (ICDAS II Score >3)	3 (10.0)	8 (27.0)	<0.001**
No Progression (ICDAS II Score 2)	4 (13.0)	13 (43.0)
Regression (ICDAS II Scores 0, 1)	23 (77.0)	9 (30.0)
Total	30 (100.0)	30 (100.0)

Groups	3 Months Mean+SD	p-value^a	6 Months Mean+SD	p-value^a	12 Months Mean+SD	p-value^a
Resin Infiltration	1.5+0.5	<0.001**	1.13+0.73	<0.001**	0.9+0.88	<0.001**
Fluoride CPP-ACP Varnish	0.30+0.59		0.4+0.89		0.06+0.82

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[1] Correspondence: Dr. Rishi Tyagi, Department of Pedodontics & Preventive Dentistry, University College of Medical Sciences (University of Delhi) and GTB Hospital, Dilshad Garden, Delhi, 110095, India. E-mail: tyagi_rishidoc@hotmail.com