Aflibercept |
metastatic colorectal cancer (mCRC) |
24/03/2014 18/11/2011 02/11/2016 |
Spain USA Mexico |
Afatinib |
locally advanced or metastatic non-small-cell lung cancer |
13/06/2014 12/07/2013 01/01/2015 |
Spain USA Colombia |
Asparaginase |
Acute leukemia, particularly lymphocytic |
14/01/2019 01/08/2002 |
Brazil USA |
Atezolizumab |
urothelial carcinoma (UC), non-small cell lung cancer (NSCLC) |
09/10/2017 18/05/2016 21/03/2018 |
Brazil USA Spain |
Avelumab |
metastatic Merkel cell carcinoma (MCC), urothelial carcinoma (UC), renal cell carcinoma (RCC) |
04/06/2018 01/09/2018 23/03/2017 |
Brazil Spain USA |
Bevacizumab |
metastatic colorectal cancer, non-small cell lung cancer, glioblastoma, and metastatic renal cell cancer |
11/02/2019 11/07/2005 26/02/2004 |
Brazil Spain USA |
Blinatumomab |
acute lymphoblastic leukemia (ALL) in adults and children |
17/04/2017 01/01/2018 03/12/2014 |
Brazil Colombia USA |
Brentuximab vedotin |
Recurrent or refractory Hodgkin’s lymphoma (HL) |
01/09/2014 12/02/2014 01/08/2014 19/08/2011 |
Brazil Colombia Spain USA |
Carfilzomib |
relapsed or refractory multiple myeloma |
01/01/2015 01/05/2018 20/07/2012 |
Colombia Spain USA |
Cetuximab |
metastatic colorectal cancer |
17/05/2007 12/02/2004 |
Spain USA |
Crizotinib |
positive advanced non-small cell lung cancer (NSCLC) |
24/07/2014 01/12/2013 26/08/2011 |
Colombia Spain USA |
Elotuzumab |
multiple myeloma |
18/12/2017 01/01/2018 30/11/2015 |
Brazil Spain USA |
Ibrutinib |
Chronic lymphocytic limphoma |
19/02/2015 01/01/2016 13/11/2013 |
Colombia Spain USA |
Inotuzumab ozogamicin |
acute lymphoblastic leukemia (ALL) |
21/01/2019 17/08/2017 |
Brazil USA |
Nivolumab |
advanced melanoma (unresectable or metastatic) and locally advanced or metastatic non-small-cell lung cancer (NSCLC) |
04/04/2016 01/01/2016 01/01/2016 22/12/2014 |
Brazil Colombia Spain USA |
Obinutuzumab |
chronic lymphocytic leukemia (CLL) |
23/03/2015 01/01/2014 19/10/2015 01/11/2013 |
Brazil Colombia Spain USA |
Ofatumumab |
chronic lymphocytic leukemia (CLL) |
01/07/2014 26/10/2009 |
Spain USA |
Olaratumab |
soft tissue sarcoma (STS) |
26/12/2017 01/11/2017 19/10/2016 |
Brazil Spain USA |
Panitumumab |
carcinoma of the colon or rectum |
20/04/2015 18/12/2007 27/09/2006 |
Brazil Spain USA |
Pegaspargase |
acute lymphoblastic leukemia (ALL) |
26/02/2018 01/06/2017 24/07/2006 |
Brazil Spain USA |
Pertuzumab |
metastatic HER2-positive breast cancer, metastatic or locally recurrent, nonresectable |
15/06/2014 08/06/2012 16/05/2017 |
Spain USA Mexico |
Ramucirumab |
advanced gastric cancer or gastroesophageal junction adenocarcinoma |
22/02/2016 01/12/2015 21/04/2014 04/08/2015 |
Brazil Spain USA Mexico |
Rituximab |
low-grade non-Hodgkin lymphoma. Chronic lymphocytic leukemia |
07/09/1998 26/11/1997 15/02/2017 |
Spain (17) USA (18) Mexico (15) |
Trastuzumab |
metastatic breast cancer, early HER2-positive cancer, and advanced gastric cancer |
18/12/2017 21/11/2000 25/09/1998 |
Brazil Spain USA |
Trastuzumab emtansine |
metastatic HER2-positive breast cancer |
06/01/2014 07/01/2014 15/06/2015 22/02/2013 |
Brazil Colombia Spain USA |