Evaluation of commercial arrowroot starch/CMC film for buccal drug delivery of glipizide

Abstract

In the present work, commercial arrowroot starch (AR starch) has been successfully used as a base material with sodium salt of carboxy methyl cellulose (CMC) for buccal drug delivery system. Different ratio of CMC and AR starch has been prepared with constant ratio of drug. In our study, glipizide has been used as the drug for controlled drug delivery through buccal mucosa. Films were cast by solution casting method with glycerol as plasticizer. All the films were characterized for thickness, swelling index, moisture content, relative pH, drug content uniformity, compatibility of polymer and drug, surface morphology of films, muco adhesive property and in-vitro drug release study. Formulation F3 shows a residence time of 140 minutes with good mucoadhesive property, compatibility within polymers, drug content uniformity of 100 ± 6.0% and a controlled drug release among all the ratios.

Keywords:
arrowroot starch; buccal drug delivery; CMC; film; glipizide