ACETANILIDE: SOLVENT-FREE GREEN SYNTHESISWe described herein a solvent-free synthesis of acetanilide developed in the context of green chemistry. The synthetic approach consisted of the reaction of aniline with acetic anhydride without additives, while using smaller amounts of reagents and water than previously described for this undergraduate experiment. The E Factor was 0.6 by experienced chemists and 0.9 by students.
Keywords
green chemistry ; acetanilide; aniline; undergraduate organic chemistry experiment; solventless reaction
