The mobilization of this article/essay is to problematize the impact that new technologies (Artificial Intelligence and Automation) have on the subjects of science, especially in the field of chemistry. In a theoretical analysis, we discuss the potential that smart technologies emerge in our daily lives, in our studies, in our professional activities and in the construction of scientific knowledge itself. In a first analysis, there are three inflections that need to be considered when such technologies fold subjects, spaces, society and that is most innate to human beings: thinking and the construction of knowledge. Thus, the movements that chemistry and its subjects have - and will have - in this emerging (4th) Industrial Revolution are problematized.