The role of the logistics in the design of synthetic pathways aimed at greenish is discussed. The influence on costs (of reagents, solvents and total), as well as on atomic productivity green metrics (atomic economy and E factor), of the position along the pathway of a step with low yield, or involving high dilution of the reagents or expensive reagents, has been evaluated by calculations on a linear pathway model. The results show the economic importance of Green Chemistry and provide useful information for pathway design or improvement.
Green Chemistry; synthetic pathway; synthesis logistics
