The binary mixtures of Brij® surfactant and Pluronic® F127 were studied as carriers of griseofulvin. The F127 systems and Brij® 78 (C18H37E20), Brij® 98 (C18H35E20) and Brij® 700 (C18H37E100) were prepared in the proportions 10/90, 30/70, 50/50 and 70/30, respectively. The characterizations were carried out by tube inversion, rheology, particle size, and theoretical cmcs. The griseofulvin solubilization tests were performed at 25 and 37 ºC in micellar solutions of 1 wt. % and quantified by UV/Vis. According to the rheological data, the presence of F127 make the F127/Brij 78 70/30 and F127/Brij 98 70/30 mixtures thermoresponsive at concentrations of 30 and 35 wt.%, with transition fluid/gel in the range of 28-30 ºC, ideal for topical use. All of the F127 / Brij 700 mixtures showed moderate distribution polydisperse (PDI < 0.4), as well as mixtures of F127 / Brij 98, with the exception of the mixture with ratio 30/70. Mixtures of F127 / Brij 78 had wide polydisperse distribution (PDI > 0.4). The optimal mixing for oral application would be of F127/Brij 78 because it exhibits greater solubilizing capacity (Scp) of griseofulvin at temperatures of 25 to 37 ºC when compared to F127 alone.
Keywords:
binary mixture; solubilization of drug; Brij® surfactant; griseofulvin
