The utilization of the safrole, principal chemical constituent of sassafras oil, in the synthesis of compounds actives in the arachidonic acid cascade: antiinflammatory, analgesic and antithrombotic

In this paper we describe the results of a research effort developed in Laboratório de Avaliação e Síntese de Substancias Bioativas (LASSBio, UFRJ) in the utilization of Brazilian abundant natural product, safrole (1), the principal chemical constituent of Sassafras oil (Ocotea pretiosa), as an attractive synthon to access different chemical class of bioactive compounds, as prostaglandins analogues, non-steroidal antiinflammatory agents and antithrombotic compounds.

safrole in synthesis; synthesis of nonsteroidal antiinflammatory drugs analogues; antithrombotic agents