IMAGE IN MEDICINE
Erythema and nipple retraction: a sign of concern
Eritema e retração do mamilo: um sinal de alerta
Husein Husein-ElAhmedI; Valeriano Garrido Torres-PucholII
IDepartment of Dermatology, Infanta Margarita Hospital, Cordoba, Spain
IIDepartment of Dermatology, Santa Ana Hospital, Granada, Spain
Corresponding author Corresponding author: Husein Husein-ElAhmed E-mail: huseinelahmed@hotmail.com
A 74-year-old woman presented with a two-year history of pruritic erythematous plaque on the left nipple. The lesion was approximately 10 cm × 7 cm in size and the normal anatomy of the nipple was destroyed. There was no palpable mass or axillary lymphadenopathy. The patient had no previous history of breast cancer. A skin biopsy was performed, which confirmed Paget's disease (PD).
PD of the nipple is an uncommon disease accounting for approximately 1-3% of all cases of breast carcinoma.1,2 This condition is a rare malignancy of the breast characterized by infiltration of the epidermis of the nipple with malignant cells known as "Paget cells". These cells are large, round or ovoid, with clear, abundant cytoplasm, and enlarged pleomorphic and hyperchromatic nucleus.3 Studies report that the association of this clinical sign with a concurrent malignancy is present in over 90% of patients.1,4 The clinical features of PD are relatively characteristic, and the clinician should be aware of the chance of a concurrent malignancy. Both benign and malignant processes may produce visible changes in the nipple, including: eczema, psoriasis, allergic contact dermatitis, lichen simplex chronicus, and squamous cell carcinoma in situ (Bowen's disease) (Fig. 1).
In a patient with suspicion of PD, a full-thickness biopsy of the nipple and areola is important to establish a diagnosis. Additional evaluation with mammography should be performed to identify underlying malignancy in patients with PD.
The present patient underwent a mastectomy and invasive ductal carcinoma was diagnosed. Lung metastasis was found, and she died after six months of follow-up.
Conflicts of interest
The authors declare no conflicts of interest.
References
- 1. Ashikari R, Park K, Huvos AG, Urban JA. Paget's disease of the breast. Cancer. 1970;26:680-5.
- 2. Kollmorgen DR, Varanasi JS, Edge SB, Carson 3rd WE. Paget's disease of the breast: a 33-year experience. J Am Coll Surg. 1998;187:171-7.
- 3. Ascensõ AC, Marques MS, Capitão-Mor M. Paget's disease of the nipple: clinical and pathological review of 109 female patients. Dermatologica. 1985;170:170-9.
- 4. Paone JF, Baker RR. Pathogenesis and treatment of Paget's disease of the breast. Cancer. 1981;48:825-9.
Publication Dates
-
Publication in this collection
05 July 2013 -
Date of issue
June 2013