COVID-19-induced de novo nephritic syndrome

Dear Editor, we would like to share ideas on the publication Is the COVID-19 disease associated with de novo nephritic syndrome?¹. Dheir et al.¹ concluded that “COVID-19-induced de novo nephritic syndrome may occur mainly due to tubulointerstitial involvement and often results in spontaneous remission. However, why these findings were not present in all patients who had no comorbidities is not clear”. A possible underlying cause of nephritic syndrome is coronavirus-antibody immune complex². Based on this process, the severity of COVID-19-induced de novo nephritic syndrome might be due to several factors including the immune response of the patient. The level of immune response in COVID-19 patients is different and this might be a possible explanation for the fact that the renal problem is not observable in all patients.

• Funding: none.

REFERENCES

• ¹
  Dheir H, Sipahi S, Yaylaci S, Genc AC, Genc FT, Genc AB, et al. Is the COVID-19 disease associated with de novo nephritic syndrome? Rev Assoc Med Bras (1992). 2020;66(9):1258-63. https://doi.org/10.1590/1806-9282.66.9.1258
  » https://doi.org/10.1590/1806-9282.66.9.1258
• ²
  Sriwijitalai W, Wiwanitkit V. Coronavirus-antibody immune complex: a nanostructure appraisal possible cause of nephropathology. Saudi J Kidney Dis Transpl. 2020;31(3):694-5. https://doi.org/10.4103/1319-2442.289457
  » https://doi.org/10.4103/1319-2442.289457

Publication Dates

• Publication in this collection
  09 June 2021
• Date of issue
  Jan 2021

History

• Received
  09 Nov 2020
• Accepted
  06 Dec 2020