| Moreira-Silva et al.1010. Moreira-Silva SF, Frauches DO, Almeida AL, Mendonça HF, Pereira FE. Acute liver failure in children: observations in Vitória, Espírito Santo State, Brasil. Rev Soc Bras Med Trop. 2002;35(5):483-6., 2002, Brasil |
Description of a series of ALF cases in children |
None |
Evaluated biochemical and serological tests of patients |
46 patients |
38 patients with hepatitis A; 2 cases with hepatitis B, and 6 cases with no diagnosis; mortality of 50% |
| Uribe et al.3939. Uribe M, Buckel E, Ferrario M, Godoy J, González G, Hunter B, et al. Pediatric liver transplantation: ten years of experience in a multicentric program in Chile. Transplant Proc. 2005;37(8):3375-7., 2005, Chile |
Analysis of epidemiology and outcomes of LT in ALF in Chile |
LT in patients from the waiting list for liver transplantation in the country |
Use of steroids, cyclosporine, and azathioprine, with the use of mycophenolate, and tacrolimus in some cases. |
42 patients, 27 submitted to LT |
27 patients with LT: 13 females; 1 male; 10 with hepatitis A; 3 autoimmune; 12 cryptogenic; 7 died after LT, with 3 unsuccessful retransplantations; 20 patients were discharged with 5-year follow up after the procedure and survived |
| Cuarterolo et al.4040. Cuarterolo M, Ciocca M, López S, Cervio G, Rojas L, Bianco G, et al. Evolution of children one year post liver transplant. Medicina (B Aires). 2005;65(5):402-8., 2005, Argentina |
The child evolution during the first year after LT |
All patients received cyclosporine |
Periodic examinations during the first year after LT |
143 patients |
Of the 143 patients, 14 needed retransplantations |
| Ciocca et al.3333. Ciocca M, Ramonet M, Cuarterolo M, López S, Cernadas C, Alvarez F. Prognostic factors in paediatric acute liver failure. Arch Dis Child. 2008;93(1):48-51., 2008, Argentina |
Study the etiology, outcome, and prognosis in children with ALF |
None |
Patient follow up until hospital discharge, death, or LT |
215 patients, but only 210 with medical records |
128 patients with hepatitis A, 68 indeterminate, and 13 of other causes; 59 survived with hospital discharge and no LT; 61 died and 90 received LT |
| Ferreira et al.3131. Ferreira CT, Vieira SM, Kieling CO, Silveira TR. Hepatitis A acute liver failure: follow-up of paediatric patients in southern Brasil. J Viral Hepat. 2008;15(Suppl 2):66-8.; 2008; Brasil |
Retrospective report of the last 10 years of children with ALF due to hepatitis A |
None |
Evaluated biochemical and serological tests of all patients |
33 patients |
13 patients were positive for hepatitis A, 11 had no cause determined, 1 had a spontaneous recovery, 5 died before LT, 7 underwent LT with total survival after of 4 patients (1 with no LT and 3 without after LT) |
| Roque et al.6161. Roque JE, Ríos GM, Pinochet CV, Vignolo PA, Humeres RA, Ríos HR, et al. Falla hepática fulminante en niños. Rev Chil Pediatr. 2009;80(2):144-9., 2009, Chile |
Report the experience of a LT center |
LT |
Evaluated biochemical and serological tests of all patients |
8 patients underwent LT between 1997 and 2008 |
5 patients received LT from a dead donor; 5 female patients; 3 had kidney failure, with 2 deaths among the 8 patients |
| Sotelo et al.5353. Sotelo N, Angeles Durazo M, Gonzalez A, Dhanakotti N. Early treatment with N-acetylcysteine in children with acute liver failure secondary to hepatitis A. Ann Hepatol. 2009;8(4):353-8., 2009, México |
Description of early use in patients with ALF secondary to hepatitis A |
Treatment with N-Acetyl Cysteine for patients with ALF secondary to hepatitis A |
Clinical symptoms and biochemical tests. |
12 patients with ALF, of 72 patients with hepatitis A |
6 males; 6 females - 9 patients received oral treatment and 3 through nasogastric intubation. Average treatment for 15 days, with one case needing more 15 days |
| Uribe et al.1616. Uribe M, Alba A, González G, Hunter B, Heine C, Iñiguez R, et al. Pediatric liver transplant outcome using severe hypernatremic donors. Transplant Proc. 2013;45(10):3726-7., 2013, Chile |
Analysis of epidemiology and outcomes of LT in ALF |
LT in patients from the waiting list for LT in the country |
Hospital protocol of immunosuppression regimen |
189 patients |
230 LT performed; ALF etiology was unknown in 50% of cases; 68% of the patients had 10-year survival, with 90% in the last 3 years |
| Silverio et al.1313. Silverio CE, Smithen-Romany CY, Hondal NI, Díaz HO, Castellanos MI, Sosa O. Acute liver failure in Cuban children. MEDICC Rev. 2015;17(1):48-54., 2015, Cuba |
Describe the outcome of children with ALF in Cuba |
None |
Evaluated biochemical and serological tests of all patients |
31 patients |
61% of the cases were infectious, 41% by cytomegalovirus; spontaneous recovery in 48% of cases (15); only 3 received LT and 13 died |
| Tannuri et al.7777. Tannuri AC, Porta G, Kazue Miura I, Santos MM, Moreira DA, Rezende NM, et al. Pediatric acute liver failure in Brasil: is living donor liver transplantation the best choice for treatment? Liver Transpl. 2016;22(7):1006-13., 2016, Brasil |
Results of LT before and after living donor LT became possible, starting in 2007 |
Living and dead donor LT in ALF patients |
Clinical symptoms and biochemical tests. |
115 patients |
48 of the 115 patients with LT indication before the institution started performing living donor transplantation, 67 after; 48% mortality after LT, with greater incidence in patients who received LT from a dead donor, 64.3% before 2007 and 50% after; 45% with undefined etiology |
