“Interstitial lung abnormalities”: translation to and use in Portuguese

Objective To conduct a survey on the use of the term “interstitial lung abnormalities” in radiology reports in Brazil, propose an appropriate Portuguese-language translation for the term, and provide a brief review of the literature on the topic. Materials and Methods A survey was sent via electronic message to various radiologists in Brazil, asking about their familiarity with the term, which translation of the term they use in Portuguese, and whether they use the criteria proposed by the Fleischner Society. Results A total of 163 responses were received, from all regions of Brazil. Although the vast majority (88%) of the respondents stated that they were familiar with the term “interstitial lung abnormalities”, there was considerable variation regarding the equivalent term they used in Portuguese. Conclusion We suggest that the term “anormalidades pulmonares intersticiais” be used in order to standardize radiology reports and disseminate knowledge of these findings in Brazil.

Unitermos: Doenças pulmonares intersticiais; Tomografia computadorizada; Fibrose pulmonar; Achados incidentais. of those findings in some patients (2)(3)(4) .That culminated in the publication of a position paper by the Fleischner Society, standardizing the definition of these findings, in 2020 (1) .In Brazil, however, we observed that this term is translated differently by different radiologists, which can create confusion in their understanding and case management.
The objective of this study was to conduct a survey regarding the use of this term in radiology reports in Brazil.We also provide a brief review of the literature on the topic.

INTRODUCTION
The term "interstitial lung abnormalities" (ILAs) can be most directly translated to Portuguese as anormalidades pulmonares intersticiais.This set of findings is characterized by abnormalities consistent with interstitial lung disease (ILD) on computed tomography (CT) in patients with no clinical suspicion of the disease (1) .It has gained relevance in recent years, after a number of scientific studies showed that such abnormalities can represent an initial stage of pulmonary fibrosis and that there is progression 0100-3984 © Colégio Brasileiro de Radiologia e Diagnóstico por Imagem doi: 10.1590/0100-3984.2023.0114-en

MATERIALS AND METHODS
Between September 1 and September 12 of 2023, a survey was sent via electronic message to several radiologists, throughout Brazil, who are considered references in thoracic radiology because of their previous participation in lectures, national conferences, and scientific publications.Each radiologist was also asked to share the survey with their coworkers and residents.
The survey consisted of questions regarding the length of experience in radiology, the Brazilian state in which they work, whether they were familiar with the term ILAs, which translation of the term they use, and whether they used the criteria proposed by the Fleischner Society (1) .Permission to use the data anonymously for academic purposes was also requested.

RESULTS
A total of 163 responses/permissions were received, from all five regions of Brazil: 103 (63.1%) from the southeastern region; 32 (19.6%) from the northeastern region; 17 (10.4%)from the central-west region; nine (5.5%) from the southern region; and two (1.2%) from the northern region.The vast majority of the responses (60%) were from the state of São Paulo.
The vast majority (88%) of the respondents stated that they were familiar with the term ILAs.However, only 60% reported using the diagnostic and classification criteria recommended by the Fleischner Society (1) .

DISCUSSION
Typically detected as incidental findings on CT of the chest, ILAs pose a risk of progression to ILD.The prevalence of ILAs is estimated to be approximately 10% in the general population, increasing with age and smoking history.Other risk factors for ILAs include male gender and exposure to air pollution, as well as occupational exposure to vapors, dust, or smoke.There is an association between ILAs and worse clinical outcomes, a finding of ILAs having a negative impact on patient survival (1)(2)(3)(4)(5)(6) .
Because of the clinical importance of identifying ILAs, the Fleischner Society defined standardized descriptive terms, as well as proposing a multidisciplinary management plan for cases in which these changes are found (1) .In the Fleischner Society paper, ILAs are defined as non-position-dependent pulmonary opacities, with diffuse distribution, involving at least 5% of any lung zone (the upper, middle and lower lung zones being separated by the levels of the inferior aortic arch and the right inferior pulmonary vein), detected incidentally in individuals without suspected ILD.The aim of establishing a 5% cutoff is to exclude minimal or dubious CT findings.The findings can include ground-glass opacities, reticulated opacities, architectural distortion, bronchiectasis, traction bronchiolectasis, honeycombing, and non-emphysematous cysts (Figure 1).There are some CT findings that should not be considered ILAs, such as position-dependent pulmonary atelectasis (Figure 2), paraspinal fibrosis adjacent to osteophytes (Figure 3), dendriform pulmonary ossification, thickening of the interlobular septum due to interstitial edema, and focal or unilateral opacities (such as those related to bronchial aspiration).In populations at high risk for ILD (such as patients with a family history of ILD, a known diagnosis of connective tissue disease, or significant occupational exposure to an agent known to be associated with ILD), changes identified during CT screening should not be considered ILAs because they are not incidental (1,2) .In addition, ILAs can be classified, according to their location(s) and the presence or absence of fibrosis, into three subtypes-non-subpleural, subpleural non-fibrotic, and subpleural fibrotic-fibrosis being characterized by architectural distortion with traction bronchiectasis or bronchiolectasis, with or without honeycombing (1,2) .
In the present study, 60% of the radiologists surveyed stated that they use the ILA subtypes in their chest CT reports.This information is relevant, because subpleural non-fibrotic and subpleural fibrotic ILAs are considered to present a high risk for progression (Figure 4).The fibrotic subtype is also associated with higher mortality than that observed for individuals without ILAs (3,7,8) .
As previously mentioned, the vast majority of the survey respondents stated that they were familiar with ILAs.However, the great variation among them in terms of how they translate the term to Portuguese in their chest CT reports could create confusion in the interpretation of these findings.We believe it is essential to standardize the term in radiology reports in order to improve interdisciplinary communication and case management.
Radiol Bras.2024;57:e20230114en Of the radiologists who responded to the survey, 31.8%stated that they used the terms alterações pulmonares incipientes ("incipient lung changes"), pneumopatia intersticial incipiente ("incipient ILD"), or sinais de intersticiopatia incipiente ("signs of incipient interstitial disease").In this context, the use of the term "incipient" implies that an alteration is in an initial phase and will presumably progress.However, some studies have shown that not all individuals with ILAs present radiological progression or develop ILD, and that some ILAs even regress (8) .Likewise, although the term alterações pulmonares intersticiais ("interstitial lung changes") was routinely used by approximately 40% of the survey respondents, it lacks precision.Despite having similar meanings in the Portuguese language, there is a more pronounced distinction between "abnormality" and "change" in the English language, the latter term being more commonly associated with the idea of replacement or difference from a previous state, making it less appropriate in this context.
Our study has some limitations.The choice of specific radiologists as recipients of the survey represents a clear selection bias.Other potential limitations are the use of electronic media to carry out the survey and the fact that the majority of the respondents had five or fewer years of experience in radiology.

CONCLUSION
We believe that direct translation of the term ILAs to anormalidades pulmonares intersticiais would be the most appropriate for use in Portuguese.We also believe that it would be appropriate to identify the subpleural non-fibrotic and subpleural fibrotic ILA subtypes, with the aim of standardizing radiology reports, thus improving communication between radiologists and professionals in other medical specialties, as well as promoting uniformity in future clinical research.In addition, measures to promote the use of this term in Portuguese are important for raising awareness and consolidating the knowledge of the concept.

Figure 3 .
Figure 3. CT findings that should not be considered ILAs.Paraspinal fibrosis in the right lower lung lobe, adjacent to spinal osteophytes.

Figure 4 .
Figure 4. Evolution of subpleural fibrotic ILAs over five years.A: Chest CT showing reticular opacities associated with traction bronchiolectasis in the lung periphery.B: Chest CT acquired five years later, showing progression of the ILAs, with increased fibrosis, together with honeycombing and architectural distortion.