Dosimetry of patients submitted to cerebral PET/CT for the diagnosis of
               mild cognitive impairment

Santana, Priscila do Carmo; Mourão, Arnaldo Prata; Oliveira, Paulo Márcio Campos de; Bernardes, Felipe Dias; Mamede, Marcelo; Silva, Teógenes Augusto da

doi:10.1590/0100-3984.2013.1800

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Sumário

ORIGINAL ARTICLES • Radiol Bras 47 (6) • Dec 2014 • https://doi.org/10.1590/0100-3984.2013.1800 copy

Dosimetry of patients submitted to cerebral PET/CT for the diagnosis of mild cognitive impairment^* * Study developed at Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil. Financial support: Dean’s Office for Research – Universidade Federal de Minas Gerais, Fundação de Amparo à Pesquisa do Estado de Minas Gerais (Fapemig), and INCT de Metrologia das Radiações.

Authorship SCIMAGO INSTITUTIONS RANKINGS

Objective:

The present study was aimed at evaluating the effective radiation dose in patients submitted to PET/CT for the diagnosis of mild cognitive impairment.

Materials and Methods:

TLD-100 detectors inserted into an Alderson Rando® anthropomorphic phantom were utilized to measure the absorbed dose coming from the CT imaging modality. The anthropomorphic phantoms (male and female adult versions) were submitted to the same technical protocols for patients’ images acquisition. The absorbed dose resulting from the radiopharmaceutical injection was estimated by means of the model proposed by the ICRP publication 106.

Results:

The effective dose in patients submitted to this diagnostic technique was approximately (5.34 ± 1.99) mSv.

Conclusion:

Optimized protocols for calculation of radioactive activity injected into patients submitted to this diagnostic technique might contribute to reduce the effective radiation dose resulting from PET/CT in the diagnosis of mild cognitive impairment.

Dosimetry; PET/CT; Mild cognitive impairment

Data	Mean	Minimum	Maximum	3rd Quartile
Age (years)	76 ± 17	39	91	83
Height (m)	1.57 ± 0.20	1.34	1.84	1.63
Mass (kg)	62.86 ± 22.43	37.3	92	70.8
Injected activity (MBq)	295.99 ± 106.21	154.66	459.36	332.22
Mean effective dose (mSv)	5.22 ± 1.84	2.75	7.99	5.87

Organ	Mean absorbed dose (mGy)
Right crystalline	25.53 ± 5.12
Left crystalline	24.91 ± 4.98
Thyroid	1.01 ± 0.20
Brain – right lobe	0.28 ± 0.06
Brain – right lobe	0.31 ± 0.06
Foramen magnum	17.64 ± 3.52
Pituitary gland	15.92 ± 3.19
Right breast	Background
Left breast	Background

Organ		Mean absorbed dose (mGy)	Maximum (mGy)	Minimum (mGy)	3rd Quartile
Adrenal glands		3.55 ± 1.27	5.51	1.86	3.99
Bladder		38.47 ± 13.82	59.72	20.11	43.19
Bone surfaces		3.26 ± 1.17	5.05	1.70	3.65
Brain		11.25 ± 4.04	17.46	5.88	12.62
Breasts		2.60 ± 0.93	4.04	1.36	2.92
Gallbladder		3.84 ± 1.39	5.97	2.01	4.32
Gastrointestinal tract
	Stomach	3.26 ± 1.17	5.05	1.70	3.65
	Small bowel	3.55 ± 1.27	5.51	1.86	3.99
	Colon	3.85 ± 1.38	5.97	2.01	4.32
	– Upper large bowel	3.55 ± 1.27	5.51	1.86	3.99
	– Lower large bowel	4.14 ± 1.49	6.43	2.17	4.65
Heart		19.83 ± 7.12	30.78	10.36	22.26
Kidneys		5.03 ± 1.81	7.81	2.63	5.65
Liver		6.22 ± 2.23	9.65	3.25	6.98
Lungs		5.92 ± 2.13	9.19	3.09	6.64
Muscles		2.96 ± 1.06	4.59	1.55	3.32
Ovaries		3.96 ± 1.44	5.98	2.17	4.41
Pancreas		3.85 ± 1.38	5.97	2.01	4.32
Red marrow		3.26 ± 1.17	5.05	1.70	3.65
Skin		2.31 ± 0.83	3.58	1.21	2.59
Spleen		3.26 ± 1.17	5.05	1.70	3.65
Testicles		3.47 ± 1.11	5.05	2.52	3.83
Thymus		3.55 ± 1.27	5.51	1.86	3.99
Thyroid		2.96 ± 1.06	4.59	1.55	3.32
Uterus		5.10 ± 1.84	7.69	2.78	5.67
Other organs		3.55 ± 1.27	5.51	1.86	3.99

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[1] Mailing Address: Dra. Priscila do Carmo Santana. Avenida Professor Alfredo Balena, 190, Departamento de Anatomia e Imagem. Belo Horizonte, MG, Brazil, 30130-100. E-mail: pridili@gmail.com.