Locally advanced hypopharyngeal squamous cell carcinoma: single-institution outcomes in a cohort of patients curatively treated either with or without larynx preservation

Reis, Isabel; Aguiar, Artur; Alzamora, Cristiana; Ferreira, Carolina; Castro, Vera; Soares, André; Lobão, Marisa

doi:10.1590/0100-3984.2015.0018

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Sumário

ORIGINAL ARTICLES • Radiol Bras 49 (1) • Jan-Feb 2016 • https://doi.org/10.1590/0100-3984.2015.0018 copy

Locally advanced hypopharyngeal squamous cell carcinoma: single-institution outcomes in a cohort of patients curatively treated either with or without larynx preservation^* * Study developed at Radiation Oncology Department, Instituto Português de Oncologia do Porto Francisco Gentil (IPO-Porto), Porto, Portugal.

Carcinoma espinocelular da hipofaringe: resultados de uma instituição numa coorte de doentes tratados com intenção curativa com ou sem preservação da laringe

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Objective:

The present study was aimed at describing a single-institution experience in the curative treatment of patients diagnosed with locally advanced hypopharyngeal squamous cell carcinoma.

Materials and Methods:

Data concerning all patients treated for locally advanced hypopharyngeal squamous cell carcinoma between January 2006 and June 2012 were reviewed.

Results:

A total of 144 patients were included in the present study. The median follow-up period was 36.6 months. Median survival was 26 months, and 2-year and 5-year overall survival rates were, 51% and 30.5%, respectively. Median recurrence-free survival was 18 months and 2-year and 5-year recurrence-free survival rates were 42.8% and 28.5%, respectively.

Conclusion:

The outcomes in the present series are in line with the literature.

Keywords:
Hypopharynx; Outcomes; Surgery; Radiotherapy

	Total	Surgery	Radical
	population	group	RT group
	(n = 144)	(n = 63)	(n = 81)
Median age (years)	54.4	55.0	52.0
Gender
Male	142 (98.6%)	62 (98.4%)	80 (98.8%)
Female	2 (1.4%)	1 (1.6%)	1 (1.2%)
Location
Piriform synus	117 (81.3%)	57 (90.5%)	60 (74.1%)
Posterior wall	8 (5.6%)	3 (4.8%)	5 (6.2%)
Post cricoide	2 (1.4%)	0	2 (2.5%)
Not otherwise specified	17 (11.8%)	3 (4.8%)	14 (17.3%)
Disease stage
III	35 (24.3%)	13 (20.6%)	22 (27.2%)
IV	109 (75.7%)	50 (79.4%)	59 (72.8%)
Induction CT	26 (18.1%)	1 (1.6%)	25 (30.9%)
Concomitant CT	112 (77.8%)	39 (61.9%)	73 (90.1%)
Enteral feeding tube	47 (32.6%)	11 (17.5%)	36 (44.4%)
Tracheostoma	69 (47.9%)	32 (50.8%)	37 (45.7%)

	Surgery group	Radical RT group
	(n = 63)	(n = 81)
Median overall survival	30 months	21 months	p = 0.274
2-year overall survival	55.6%	47.5%
5-year overall survival	32.8%	29.2%

	Surgery	Radical RT
	group	group
	(n = 63)	(n = 81)
Median recurrence free survival	22 months	13 months	p = 0.126
2-year recurrence free survival	47.5%	39.1%
5-year recurrence free survival	~31.0%	24.1%

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[1] Mailing Address: Dra. Isabel Reis. Rua Doutor António Bernardino de Almeida, 4200-072. Porto, Portugal. E-mail: isabelreis_85@hotmail.com.