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Halo sign nodules in angioinvasive pulmonary aspergillosis: correlation of high-resolution computed tomography findings with anatomopathology

The aim of this study was to correlate the early findings observed on high-resolution computed tomography with anatomopathology results of patients with angioinvasive aspergillosis. The authors studied two patients with leukemia. The nodules seen on high-resolution computed tomography corresponded to areas of hemorrhagic infarction, necrotic coagulation and fungal hyphae infiltration whereas ground glass halo corresponded to intraalveolar hemorrhage. Nodules with halo sign were closely correlated with anatomopathology findings. We concluded that the anatomopathology findings can clearly explain the image features of the lesions observed on high-resolution computed tomography.

Angioinvasive aspergillosis; High-resolution computed tomography; Anatomopathology; Lungs


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