To identify main complications in outpatient follow-up, as well as factors before or during operation that may interfere in patient's evolution.
Retrospective study of patients submitted to total cavopulmonary shunt with extracardiac conduit from 2000 to 2014 at the Hospital do Coração (São Paulo, Brazil) and who underwent clinical follow-up at this institution.
One hundred and fifty surgeries were performed and 59 patients maintained outpatient follow-up. The mean age of these patients at the time of surgery was 4.45 years (median of 45 months) and 70.2% of them were males. Among the patients undergoing outpatient follow-up, postoperative time at evaluation ranged from 10 days to 145 months; 30 (50.8%) patients had single left ventricle and 29 (49.2%) had single right ventricle (48.2% of these presented with hypoplastic left heart syndrome [HLHS]). Patients with single left ventricle had a higher percentage of reintervention-free survival, but without statistically significant difference. 40% of the patients had no complications and 35% of them presented with thrombosis at some point in the follow-up period, with ventricular dysfunction being the second most frequently found complication (15% of cases), mainly among patients with single right ventricle morphology (P=0.04). Between the patients currently under follow-up, 20 (35%) of them had been evaluated by ultrasonography and had some degree of hepatic congestion and/or hepatomegaly. 16.7% of the patients with such alteration had HLHS (P=0.057).
Except for the right ventricular morphology, no other factor has been shown to interfere in late evolution after total cavopulmonary shunt.
Fontan Procedure; Heart Defects, Congenital; Treatment Outcome; Heart Ventricles/Pathology
Single ventricular hearts correspond to a group of congenital heart diseases, with different anatomical combinations that culminate in a common characteristic: a single ventricle responds by both the systemic and pulmonary circulations. In most cases, it is possible to confirm the presence of two distinct ventricles, right and left, one being hypoplastic and called rudimentary and the other being well formed and called the main chamber.
One of the most common anatomic forms is the tricuspid atresia, with different presentations, which is responsible for 1.5-3% of congenital heart diseases and is present in approximately 0.6 out of every 10,000 live births. Another dominant left ventricular presentation is the pulmonary atresia, with intact interventricular septum, which accounts for about 1% of congenital heart diseases, occurring in about 0.7 out of every 10,000 newborns. Regarding to the dominant right ventricle, the main anatomical representation is the hypoplastic left heart syndrome (HLHS), which represents about 2% of congenital heart diseases, being present in approximately four out of every 10,000 newborns.
The natural history of single ventricular hearts is quite unfavorable: 64% of the patients were diagnosed during childhood and 50% in the neonatal period.
Treatment is usually performed through surgical staging, with interventions beginning in the neonatal period and culminating in the completion of a total cavopulmonary operation (Fontan)[11 Fontan F, Baudet E. Surgical repair of tricuspid atresia. Thorax. 1971;26(3):240-8.], as a final stage.
The total cavopulmonary bypass allows close-to-normal saturation to these patients, decreasing the demand of the systemic ventricle. Despite this, it maintains altered hemodynamics leading to a series of late complications, among them, physical capacity reduction, ventricular dysfunction, intra- or extracardiac thrombi, arrhythmias, protein-losing enteropathy (PLE), and cirrhosis.
We carried out this study in order to evaluate the complications presented in the population submitted to total cavopulmonary bypass, with late follow-up at our institution, and to assess factors that may predispose to these complications, in addition to estimate the reintervention-free survival.
To evaluate the late evolution of patients submitted to total cavopulmonary derivation with extracardiac conduit, with respect to complications (thrombi, PLE, ventricular and/or valvular dysfunction) presented and the need for reintervention.
To evaluate factors that may interfere in the occurrence of complications or the need for reintervention: diagnosis, age of total cavopulmonary bypass, pulmonary vascular resistance and pressure, use of acetylsalicylic acid (ASA) or oral anticoagulation, and fenestration.
To evaluate signs of congestion and/or hepatic parenchyma alteration after five years of total cavopulmonary shunt through abdominal ultrasonography (USG).
This is a retrospective study using a chart analysis of 59 patients followed-up at the Single Ventricle Heart outpatient clinic of the Hospital do Coração (São Paulo, Brazil). To do so, we considered all patients undergoing total cavopulmonary bypass between 2000 and 2014. Patients with early death (in-hospital) and those under ambulatory follow-up at other institutions were excluded.
Anatomical and surgical data were obtained through a medical record survey conducted during in-hospital period and then outpatient follow-up.
Regarding the data of the surgical moment, we evaluated: diagnosis, staging performed, age of total cavopulmonary derivation, fenestration, pulmonary artery angioplasty/stenting, preoperative pulmonary pressure, preoperative pulmonary strength, and need for reintervention.
Concerning the late follow-up, we evaluated the occurrence of main late complications, such as: thrombi, arrhythmias, ventricular dysfunction, PLE, plastic bronchitis, and changes in hepatic parenchyma through abdominal USG.
Considering main late complications, we tried to identify factors that could interfere in the occurrence of complications and reintervention-free survival.
Initially all variables were analyzed descriptively. Analysis of quantitative variables was done by observing the minimum and maximum values and calculating means, standard deviations and median. Absolute and relative frequencies were calculated for qualitative variables. To test the homogeneity between proportions, chi-square test[22 Rosner B. Fundamentals of biostatistics. 2nd ed. Boston: PWS Publishers; 1986.] or Fisher's exact test was used.
The study of time until reintervention was performed through Kaplan-Meyer curve with log-rank test[22 Rosner B. Fundamentals of biostatistics. 2nd ed. Boston: PWS Publishers; 1986.]. The software used for the calculations was SPSS 17.0 for Windows(r).
The level of significance used for the tests was 5%.
During the study (from 2000 to 2014), 150 total cavopulmonary shunt operations were performed with an extracardiac conduit. Of these, 59 patients were followed-up at the Single Ventricular Heart outpatient unit of the Hospital do Coração.
These patients' ages varied from 10 to 186 months (mean of 4.45 years, standard deviation of 28.91 months, and median of 45 months), being 40 (70.2%) males and 17 (29.8%) females.
At the time of the study, follow-up time ranged from 10 days to 145 months (mean of 48.81 months, standard deviation of 36.68 months, and median of 37.37 months).
The distribution of patients being followed-up at our institution by diagnosis is detailed in Table 1. Thirty (50.8%) patients had left single ventricle and 29 (49.2%) had right single ventricle (48.2% of these patients presented with HLHS).
Distribution of patients by diagnosis.
Among the patients with HLHS, 13 were submitted to the hybrid procedure (branch pulmonary arteries banding and stent implantation in ductus arteriosus) and only one was submitted to Norwood-Sano reconstruction as the first stage.
Fenestration between the extracardiac conduit and the right atrium was performed in 22 (37.2%) patients and the mean pulmonary artery pressure (MPAP) evaluated by preoperative catheterization was > 15 mmHg in 20 (33.8%) patients.
Reintervention was necessary in 12 patients during follow-up for the reasons listed in Table 2. Among them, six patients had fenestration (P=0.31), two had a diagnosis of HLHS (P=1.00), and four had MPAP > 15 mmHg in the catheterization performed prior to total cavopulmonary bypass (P=1.00); none of these three factors could be related to the need for postoperative reintervention. When comparing it with the intervention-free evolution showed in Figure 1, it is observed that the curves are mixed, so the need for reintervention was not related to ventricular morphology in the study group.
Interventions required during the postoperative period of total cavopulmonary shunt, considering the diagnosis and interval between total cavopulmonary shunt and reintervention.
Among the patients evaluated, 31 (52%) presented with at least one of the complications considered; the complications found in late evolution are distributed as shown in Figure 2.
Two patients have died during the follow-up. However, among the 20 patients who presented with thrombosis at sometime of the follow-up, 50% of them were in the group of patients treated with anticoagulant therapy (P=0.54), the most common site being the extracardiac tube.
Regarding the PLE, it occurred in five patients (8.4%), two of them in the group with fenestrated tube (P=1.00); one patient had HLHS (P=1.00) and two patients were in the group with preoperative pulmonary pressure > 15 mmHg (P=0.6). Therefore, none of these factors can be related to the PLE occurrence in the postoperative period.
As secondary findings, ventricular dysfunction was present on echocardiogram in nine (15%) patients, five of them had fenestration (P=0.49); 77% had a right ventricle (P=0.04) and two had pulmonary pressure > 15 mmHg (P=1.00). Right ventricular morphology was the only factor that alone had statistically significant relationship with ventricular dysfunction in the outpatient follow-up of these patients.
In our institution, it is part of the postoperative follow-up protocol of patients submitted to total cavopulmonary bypass the abdominal USG examination at the postoperative fifth year to search for parenchymal alterations and/or signs of congestion justifying further investigation of possible hepatic cirrhosis. Among patients currently undergoing follow-up, 20 (35%) have been evaluated by USG and 10 (50%) presented with some degree of hepatic congestion and/or hepatomegaly. Between patients with this alteration, 16.7% of them had HLHS (P=0.057), 60% presented with pulmonary pressure > 15 mmHg and in 54% of them the tube was not fenestrated (P=1.00).
Evolution and improvement in diagnosis, indication, surgical techniques, and postoperative care of patients with univentricular hearts have allowed an increasing survival rate of these patients, with quality of life quite close to normal. Thus, learning about the late complications to which this group of patients is subjected is fundamental. To improve care, it is essential to look at this group of patients in order to assess their demands.
Current late complications still very much resemble those found in recent years in the literature, even with the improvement of the technique proposed by Fontan in 1971[11 Fontan F, Baudet E. Surgical repair of tricuspid atresia. Thorax. 1971;26(3):240-8.].
With the use of the technique based on extracardiac tube (technique used in all patients in this study), the difference in morbidity and mortality was mainly due to the occurrence of arrhythmias: the use of extracardiac tube to derive the flow from the inferior vena cava to the right pulmonary artery reduced significantly this occurrence[33 Robbers-Visser D, Miedema M, Nijveld A, Boersma E, Bogers AJ, Haas F, et al. Results of staged total cavopulmonary connection for functionally univentricular hearts; comparison of intra-atrial lateral tunnel and extracardiac conduit. Eur J Cardiothorac Surg. 2010;37(4):934-41.].
The use of the extracardiac polytetrafluoroethylene (PTFE) tube in all cavopulmonary bypass surgeries at our service without atrial scarring and without altering the atrium architecture justifies the absence of arrhythmias in the follow-up group at our center.
Currently, at the Hospital do Coração, all patients undergoing total cavopulmonary shunt are maintained using subcutaneous enoxaparin sodium, dose of 1 mg/kg/dose, 12/12 hours, until stabilization and possibility of oral anticoagulation. Oral anticoagulation is the prophylaxis of choice for thrombosis in these patients in the first two postoperative years and it is not performed in patients with social contraindication or drug intolerance. After two years, in the absence of episodes of thrombosis, all patients started to use ASA as prophylaxis, indefinitely. During follow-up, all patients underwent transesophageal echocardiography to evaluate the possibility of thrombi in the Fontan circuit, in five days, 90 days, 180 days, nine months, one year, 18 months, and two years postoperatively; after two years, they were evaluated once a year or whenever it was necessary. Thrombosis occurred in 35% of the patients, a higher occurrence than it is usually shown in the literature: 0-16% and 4.6%, according to some reports[44 Marrone C, Galasso G, Piccolo R, Leva F, Paladini R, Piscione F, et al. Antiplatelet versus anticoagulation therapy after extracardiac conduit Fontan: a systematic review and meta-analysis. Pediatr Cardiol. 2011;32(1):32-9.], especially in the extracardiac tube and with no difference between the groups using ASA or oral anticoagulant, similar to a finding in a multicenter study published in 2011, which has found a 21% occurrence of thrombosis in the ASA group and 24% in the oral anticoagulant group[55 Monagle P, Cochrane A, Roberts R, Manlhiot C, Weintraub R, Szechtman B, et al; Fontan Anticoagulation Study Group. A multicenter, randomized trial comparing heparin/warfarin and acetylsalicylic acid as primary thromboprophylaxis for 2 years after the Fontan procedure in children. J Am Coll Cardiol. 2011;58(6):645-51.].
Another prospective study carried out in our department followed for two years a group of 40 patients submitted to cavopulmonary bypass, 20 in use of antiplatelet agent and 20 in use of oral anticoagulant, evidencing the absence of a statistically significant relation in the occurrence of thrombosis between the two groups, but showing a trend towards a greater deposit of material on the wall of the extracardiac tube, which was evidenced by computed tomography, in patients taking ASA[66 Pessotti CF, Jatene MB, Jatene IB, Oliveira PM, Succi FM, Moreira VM, et al. Comparative trial of the use of antiplatelet and oral anticoagulant in thrombosis prophylaxis in patients undergoing total cavopulmonary operation with extracardiac conduit: echocardiographic, tomographic, scintigraphic, clinical and laboratory analysis. Rev Bras Cir Cardiovasc. 2014;29(4):595-605.].
PLE is a serious event; its occurrence is found in most of the literature ranging from 1% to 5% of the patients and it has a 50% mortality rate in 5 years[77 Schumacher KR, Cools M, Goldstein BH, Ioffe-Dahan V, King K, Gaffney D, et al. Oral budesonide treatment for protein-losing enteropathy in Fontan-palliated patients. Pediatr Cardiol. 2011;32(7):966-71.,88 Thacker D, Patel A, Dodds K, Goldberg DJ, Semeao E, Rychik J. Use of oral budesonide in the management of protein-losing enteropathy after the Fontan operation. Ann Thorac Surg.2010;89(3):837-42.].
Of the patients followed-up in our center, 7% developed with such complication. Among them, one required surgical intervention for the correction of major mitral valve insufficiency, with resolution of the condition. In a second case, we chose to perform a fenestration, and the child evolved to death postoperatively. Since the beginning of the use of oral budesonide in our service for the treatment of PLE, all other patients had this condition resolved, maintaining a serum level of albumin > 3 g/dL.
Regarding the ventricular dysfunction, it is a constant concern in the late follow-up of patients with univentricular heart morphology, because in addition to the cardiac insufficiency manifested in patients with ventricular dysfunction of any nature, it may compromise the operation of the Fontan type circuit, leading to pulmonary venocapilar congestion. Its occurrence was higher in patients with single ventricle of right morphology in our series and because of this the concern to preserve this ventricle is greater since the beginning of the follow-up. A study based on records from Australia and New Zealand of patients undergoing Fontan surgery (1268 in 2015) showed 7% of patients on (angiotensin converting enzyme) ACE inhibitors in order to preserve normal function and 36% systolic or diastolic dysfunction of the single ventricle. The use prevailed in patients with right ventricular morphology (70%)[99 Wilson TG, Iyengar AJ, Winlaw DS, Weintraub RG, Wheaton GR, Gentels Tl, et al; Australia and New Zealand Fontan Registry. Use of ACE inhibitors in Fontan: rational or irrational? Int J Cardiol. 2016;210:95-9.].
Among the patients currently under follow-up, 35% have already underwent abdominal USG and 50% of them have alterations characterized by hepatic congestion. Between those, 16.7% of the alterations are in patients with HLHS (P=0.057). Hepatic impairment has been widely studied these days, being found from congestion to liver fibrosis and cirrhosis, changes that are directly related to the time since total cavopulmonary derivation[1010 Goldberg DV, Surrey LF, Glatz AC, Dodds K, O'Byrne ML, Lin HC, et al. Hepatic fibrosis is universal following Fontan operation, and severity is associated with time from surgery: a liver biopsy and hemodynamic study. J Am Heart Assoc. 2017;6(5). pii:e004809.,1111 Pundi KN, Johnson JN, Dearani JA, Pundi KN, Li Z, Hinck CA, et al. 40-year follow-up after the Fontan operation: long-term outcomes of 1,052 patients. J Am Coll Cardiol. 2015;66(15):1700-10.].
Current studies have shown a concern in proposing a protocol to evaluate liver changes in relation to periodicity of computed tomography, magnetic resonance imaging, and liver biopsy in search for precursor changes of hepatocarcinoma[1212 Evans WN, Winn BJ, Yumiaco NS, Galindo A, Rothman A, Acherman RJ, et al. Transvenous hepatic biopsy in stable Fontan patients undergoing cardiac catheterization. Pediatr Cardiol. 2014;35(7):1273-8.,1313 Asrani SK, Warnes CA, Kamath PS. Hepatocellular carcinoma after the Fontan procedure. N Engl J Med. 2013;368(18):1756-7.].
Complications such as thrombi and PLE were present in the assessed group during outpatient follow-up, but no notable relation with any of the pre or intraoperative factors assessed was found, so it remains a challenge to establish the best way to prevent and treat such complications in patients undergoing total cavopulmonary shunt.
No patient so far has evolved with arrhythmias or plastic bronchitis. Among the patients in follow-up, two had death as an outcome.
Among the evaluated causes that could interfere in the complications found, only the right ventricular morphology was statistically significant with ventricular dysfunction.
Regarding the hepatic congestion, the abdominal USG has shown signs of hepatic congestion in 50% of the evaluated cases, and a significant portion of them has been diagnosed with HLHS.
In order to evaluate parenchymal alterations, the indication of computed tomography and liver biopsy may be considered in patients with sign of congestion.
It is important to consider a better evaluation throughout this follow-up, trying to identify tissue changes, which are possibly precursors of hepatocellular carcinoma
This study was carried out at Hospital do Coração (HCor), São Paulo, SP, Brazil.
No financial support.
1Fontan F, Baudet E. Surgical repair of tricuspid atresia. Thorax. 1971;26(3):240-8.
2Rosner B. Fundamentals of biostatistics. 2nd ed. Boston: PWS Publishers; 1986.
3Robbers-Visser D, Miedema M, Nijveld A, Boersma E, Bogers AJ, Haas F, et al. Results of staged total cavopulmonary connection for functionally univentricular hearts; comparison of intra-atrial lateral tunnel and extracardiac conduit. Eur J Cardiothorac Surg. 2010;37(4):934-41.
4Marrone C, Galasso G, Piccolo R, Leva F, Paladini R, Piscione F, et al. Antiplatelet versus anticoagulation therapy after extracardiac conduit Fontan: a systematic review and meta-analysis. Pediatr Cardiol. 2011;32(1):32-9.
5Monagle P, Cochrane A, Roberts R, Manlhiot C, Weintraub R, Szechtman B, et al; Fontan Anticoagulation Study Group. A multicenter, randomized trial comparing heparin/warfarin and acetylsalicylic acid as primary thromboprophylaxis for 2 years after the Fontan procedure in children. J Am Coll Cardiol. 2011;58(6):645-51.
6Pessotti CF, Jatene MB, Jatene IB, Oliveira PM, Succi FM, Moreira VM, et al. Comparative trial of the use of antiplatelet and oral anticoagulant in thrombosis prophylaxis in patients undergoing total cavopulmonary operation with extracardiac conduit: echocardiographic, tomographic, scintigraphic, clinical and laboratory analysis. Rev Bras Cir Cardiovasc. 2014;29(4):595-605.
7Schumacher KR, Cools M, Goldstein BH, Ioffe-Dahan V, King K, Gaffney D, et al. Oral budesonide treatment for protein-losing enteropathy in Fontan-palliated patients. Pediatr Cardiol. 2011;32(7):966-71.
8Thacker D, Patel A, Dodds K, Goldberg DJ, Semeao E, Rychik J. Use of oral budesonide in the management of protein-losing enteropathy after the Fontan operation. Ann Thorac Surg.2010;89(3):837-42.
9Wilson TG, Iyengar AJ, Winlaw DS, Weintraub RG, Wheaton GR, Gentels Tl, et al; Australia and New Zealand Fontan Registry. Use of ACE inhibitors in Fontan: rational or irrational? Int J Cardiol. 2016;210:95-9.
10Goldberg DV, Surrey LF, Glatz AC, Dodds K, O'Byrne ML, Lin HC, et al. Hepatic fibrosis is universal following Fontan operation, and severity is associated with time from surgery: a liver biopsy and hemodynamic study. J Am Heart Assoc. 2017;6(5). pii:e004809.
11Pundi KN, Johnson JN, Dearani JA, Pundi KN, Li Z, Hinck CA, et al. 40-year follow-up after the Fontan operation: long-term outcomes of 1,052 patients. J Am Coll Cardiol. 2015;66(15):1700-10.
12Evans WN, Winn BJ, Yumiaco NS, Galindo A, Rothman A, Acherman RJ, et al. Transvenous hepatic biopsy in stable Fontan patients undergoing cardiac catheterization. Pediatr Cardiol. 2014;35(7):1273-8.
13Asrani SK, Warnes CA, Kamath PS. Hepatocellular carcinoma after the Fontan procedure. N Engl J Med. 2013;368(18):1756-7.
Publication in this collection
26 Nov 2017
07 Feb 2018