Dyspnea/breathlessness/shortness of breath[77 Bozbas SS, Akçay S, Ulu EK, Büyüklü F, Bozbas H. Cardiovocal (ortner's) syndrome: an unusual vascular complication. Türkiye Klinikleri Arch Lung. 2010;11(1):39-41.,88 Brunhuber C, Le Borgne P. Hoarseness as the initial symptom of aortic arch aneurysm. Ann Thorac Surg. 2016;102(4):e365. doi:10.1016/j.athoracsur.2016.04.065. https://doi.org/10.1016/j.athoracsur.201...
,1313 Garrido JM, Esteban M, Lara J, Rodriguez-Vazquez JF, Verdugo-Lopez S, Lopez-Checa S. Giant aortic arch aneurysm and cardio-vocal syndrome: still an open-surgery indication. Cardiol Res. 2011;2(6):304-6. doi:10.4021/cr101w. https://doi.org/10.4021/cr101w...
,1414 Gulel O, Elmali M, Demir S, Tascanov B. Ortner's syndrome associated with aortic arch aneurysm. Clin Res Cardiol. 2007;96(1):49-50. doi:10.1007/s00392-006-0454-z. https://doi.org/10.1007/s00392-006-0454-...
,2525 Matteucci ML, Rescigno G, Capestro F, Torracca L. Aortic arch patch aortoplasty for Ortner's syndrome in the age of endovascular stented grafts. Tex Heart Inst J. 2012;39(3):401-4.,2626 Menon MC, Benjam in S, Paul M, Knohl SJ. Ortner syndrome in an elderly vasculopath. South Med J. 2008;101(12):1279. doi:10.1097/SMJ.0b013e318185732d. https://doi.org/10.1097/SMJ.0b013e318185...
,3030 Nishimura Y, Okamura Y, Uchita S, Honda K. Abrupt rupture of an aortic arch aneurysm into the pulmonary artery. Eur J Cardiothorac Surg. 2009;36(1):212-3. doi:10.1016/j.ejcts.2009.03.007. https://doi.org/10.1016/j.ejcts.2009.03....
,3535 Shahul HA, Manu MK, Mohapatra AK, Magazine R. Ortner's syndrome. BMJ Case Rep. 2014;2014:bcr2013200950. doi:10.1136/bcr-2013-200950. https://doi.org/10.1136/bcr-2013-200950...
,4949 Elzamzamy UA, Joharjy IA. Thoracic aortic aneurysm presenting only as vocal cord paralysis. Neurosciences (Riyadh). 2007;12(3):245-8.,5151 Jaafar R, Mohamad I. Hoarseness as the sole symptom of an impending thoracic aneurysm rupture? Malays Fam Physician. 2014;9(1):25-7.,5252 Joseph TK, Nair R. Combined recurrent laryngeal and phrenic nerve paralysis due to aortic arch aneurysm. Int J Phonosurg Laryngol. 2013;3(2):58-60. doi:10.5005/jp-journals-10023-1064. https://doi.org/10.5005/jp-journals-1002...
,6060 Özyurtlu F, Acet H, Bilik MZ, Tasal A. [Ortner's syndrome caused by dissecting aortic aneurysm]. Türk Kardiyol Dern Ars. 2013;41(3):225-7. doi:10.5543/tkda.2013.47935. Turkish. https://doi.org/10.5543/tkda.2013.47935...
,7272 Wijesinghe SNR, Yasaratne BMGD, Madegedara RMD. Silent rupture of aortic aneurysm mimicking lung malignancy. Indian J Chest Dis Allied Sci. 2013;55(2):113-5.,6464 Rai SP, Acharya V. An unusual case of recurrent laryngeal nerve palsy presenting as hoarseness due to an aortic arch saccular aneurysm causing neurovascular conflict! Ann Indian Acad Otorhinolaryngol Head Neck Surg. 2017;1(1):32-3. doi:10.4103/aiao.aiao_3_18. https://doi.org/10.4103/aiao.aiao_3_18...
]
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14 (18.7) |
Cough[22 Sarangi PK, Hui P, Sagar HS, Kisku DK, Mohanty J. Combined left recurrent laryngeal nerve and phrenic nerve palsy: a rare presentation of thoracic aortic aneurysm. J Clin Diagn Res. 2017;11(5):TD01-2. doi:10.7860/JCDR/2017/25035.9765. https://doi.org/10.7860/JCDR/2017/25035....
,1616 Dutra BL, Campos Lda C, Marques Hde C, Vilela VM, Carvalho RE, Duque AG. Ortner's syndrome: a case report and literature review. Radiol Bras. 2015;48(4):260-2. doi:10.1590/0100-3984.2013.1836. https://doi.org/10.1590/0100-3984.2013.1...
,1717 Kalra DK, Zoghbi WA. Hoarseness, hemoptysis and a hole in the aorta: a case review. Echocardiography. 2003;20(3):293-4. doi:10.1046/j.1540-8175.2003.03030.x. https://doi.org/10.1046/j.1540-8175.2003...
,2424 Mathai J, Swapna UP. Hoarseness as a presenting feature of aortic arch aneurysm. Indian J Otolaryngol Head Neck Surg. 2006;58(3):309-10. doi:10.1007/BF03050855. https://doi.org/10.1007/BF03050855...
,2727 Miller CP, Firoozan S, Woo EK, Apps A. Chronic cough: a herald symptom of thoracic aortic aneurysm in a patient with a bicuspid aortic valve. BMJ Case Rep. 2014;2014:bcr2014205005. doi:10.1136/bcr-2014-205005. https://doi.org/10.1136/bcr-2014-205005...
,3535 Shahul HA, Manu MK, Mohapatra AK, Magazine R. Ortner's syndrome. BMJ Case Rep. 2014;2014:bcr2013200950. doi:10.1136/bcr-2013-200950. https://doi.org/10.1136/bcr-2013-200950...
,4242 Zangirolami AC, Oliveira FV, Tepedino MS. Ortner's syndrome: secondary laryngeal paralysis caused by a great thoracic aorta aneurysm. Int Arch Otorhinolaryngol. 2015;19(2):180-2. doi:10.1055/s-0034-1397331. https://doi.org/10.1055/s-0034-1397331...
,4646 Bagul M, Mehra R, Agrawal P. Cardiovocal or Ortner's syndrome due to aortic arch pseudoaneurysm. J Case Rep. 2016;6(3):420-3. doi:10.17659/01.2016.0102. https://doi.org/10.17659/01.2016.0102...
,4848 Che GW, Chen J, Liu LX, Zhou QH. Aortic arch aneurysm rupture into the lung misdiagnosed as lung carcinoma. Can J Surg. 2008;51(4):E91-2.,4949 Elzamzamy UA, Joharjy IA. Thoracic aortic aneurysm presenting only as vocal cord paralysis. Neurosciences (Riyadh). 2007;12(3):245-8.,5151 Jaafar R, Mohamad I. Hoarseness as the sole symptom of an impending thoracic aneurysm rupture? Malays Fam Physician. 2014;9(1):25-7.,6161 Palanisamy V, Doshi KS, Tengku Nun Ahmad TE, Abu Bakar MZ, Rajagopalan R. Ortner's syndrome: a rare cause of unilateral vocal cord paralysis. Glob J Medical Clin Case Rep. 2017;4(3):69-71. doi:10.17352/2455-5282.000051. https://doi.org/10.17352/2455-5282.00005...
,6464 Rai SP, Acharya V. An unusual case of recurrent laryngeal nerve palsy presenting as hoarseness due to an aortic arch saccular aneurysm causing neurovascular conflict! Ann Indian Acad Otorhinolaryngol Head Neck Surg. 2017;1(1):32-3. doi:10.4103/aiao.aiao_3_18. https://doi.org/10.4103/aiao.aiao_3_18...
,7373 Wu JT, Lai YF. Hoarseness as a first manifestation of aortotracheal fistula. Am J Emerg Med. 2009;27(8):1019.e1-3. doi:10.1016/j.ajem.2008.12.022. https://doi.org/10.1016/j.ajem.2008.12.0...
]
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14 (18.7) |
Chest/back pain[22 Sarangi PK, Hui P, Sagar HS, Kisku DK, Mohanty J. Combined left recurrent laryngeal nerve and phrenic nerve palsy: a rare presentation of thoracic aortic aneurysm. J Clin Diagn Res. 2017;11(5):TD01-2. doi:10.7860/JCDR/2017/25035.9765. https://doi.org/10.7860/JCDR/2017/25035....
3 Akhtar J, Siddiqui MA, Khan NA, Alam MA. Right phrenic nerve palsy: a rare presentation of thoracic aortic aneurysm. Malays J Med Sci. 2013;20(4):98-101.-44 Al Kindi AH, Al Kindi FA, Al Abri QS, Al Kemyani NA. Ortner's syndrome: cardiovocal syndrome caused by aortic arch pseudoaneurysm. J Saudi Heart Assoc. 2016;28(4):266-9. doi:10.1016/j.jsha.2016.02.006. https://doi.org/10.1016/j.jsha.2016.02.0...
,1010 Ejazi MA, Alam MM, Shameem M, Bhargava R, Adil Wafi CG, Salauddin. Thoracic aortic aneurysm: a rare cause of elevated hemidiaphragm. Lung India. 2016;33(4):430-3. doi:10.4103/0970-2113.184917. https://doi.org/10.4103/0970-2113.184917...
,1313 Garrido JM, Esteban M, Lara J, Rodriguez-Vazquez JF, Verdugo-Lopez S, Lopez-Checa S. Giant aortic arch aneurysm and cardio-vocal syndrome: still an open-surgery indication. Cardiol Res. 2011;2(6):304-6. doi:10.4021/cr101w. https://doi.org/10.4021/cr101w...
,1515 Hamamoto H, Miyamoto S, Anai H, Sako H, Iwata E, Hadama T. Successful treatment of a salmonella aortic arch aneurysm. Jpn J Thorac Cardiovasc Surg. 2003;51(2):59-61. doi:10.1007/BF02719168. https://doi.org/10.1007/BF02719168...
,1919 Kuan WS, Lee SK, Suat Ooi SB. Chronic voice hoarseness: when is it an emergency? Eur J Emerg Med. 2007;14(6):360-2. doi:10.1097/MEJ.0b013e3280bef945. https://doi.org/10.1097/MEJ.0b013e3280be...
,2323 Llerena L, Marcos-Gutiérrez Y, Mendoza-Rodríguez V, Olivares-Aquiles E. A patient complaining of hoarseness with an aneurysm of the aortic arch (Ortner's syndrome) and a left intrathoracic goiter. Internet J Radiol. 2008:9(2):1-4.,3131 Ohki M. Thoracic saccular aortic aneurysm presenting with recurrent laryngeal nerve palsy prior to aneurysm rupture: a prodrome of thoracic aneurysm rupture? Case Rep Otolaryngol. 2012;2012:367873. doi:10.1155/2012/367873. https://doi.org/10.1155/2012/367873...
,3232 Okada K, Yamanaka K, Sakamoto T, Inoue T, Matsumori M, Kawakami F, et al. In situ total aortic arch replacement for infected distal aortic arch aneurysms with penetrating atherosclerotic ulcer. J Thorac Cardiovasc Surg. 2014;148(5):2096-100. doi:10.1016/j.jtcvs.2014.02.015. https://doi.org/10.1016/j.jtcvs.2014.02....
,4040 Van Doorn RC, Reekers J, de Mol BA, Obertop H, Balm R. Aortoesophageal fistula secondary to mycotic thoracic aortic aneurysm: endovascular repair and transhiatal esophagectomy. J Endovasc Ther. 2002;9(2):212-7. doi:10.1177/152660280200900213. https://doi.org/10.1177/1526602802009002...
,6969 Sim MY, Lim YC, So SC, Zhang J, Teo DB. A hoarse warning: Ortner's syndrome. Am J Med. 2018;131(12):1460-2. doi:10.1016/j.amjmed.2018.07.036. https://doi.org/10.1016/j.amjmed.2018.07...
,7070 Tan TXZ, Balakrishnan T, Lam MHH, Chui YY, Cheng LT. A case of hoarseness with acute back pain - cardiovocal syndrome revisited. J Radiol Case Rep. 2019;13(7):21-8.]
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13 (17.3) |
Dysphagia[33 Akhtar J, Siddiqui MA, Khan NA, Alam MA. Right phrenic nerve palsy: a rare presentation of thoracic aortic aneurysm. Malays J Med Sci. 2013;20(4):98-101.,1313 Garrido JM, Esteban M, Lara J, Rodriguez-Vazquez JF, Verdugo-Lopez S, Lopez-Checa S. Giant aortic arch aneurysm and cardio-vocal syndrome: still an open-surgery indication. Cardiol Res. 2011;2(6):304-6. doi:10.4021/cr101w. https://doi.org/10.4021/cr101w...
,1616 Dutra BL, Campos Lda C, Marques Hde C, Vilela VM, Carvalho RE, Duque AG. Ortner's syndrome: a case report and literature review. Radiol Bras. 2015;48(4):260-2. doi:10.1590/0100-3984.2013.1836. https://doi.org/10.1590/0100-3984.2013.1...
,1919 Kuan WS, Lee SK, Suat Ooi SB. Chronic voice hoarseness: when is it an emergency? Eur J Emerg Med. 2007;14(6):360-2. doi:10.1097/MEJ.0b013e3280bef945. https://doi.org/10.1097/MEJ.0b013e3280be...
,2020 Kyaw WA, Lim CY, Khalil MAM, Lim KC, Chong VH, Tan J. A fatal case of Ortner's syndrome and dysphagia aortica secondary to rapidly expanding mycotic thoracic aortic aneurysm in a chronic kidney disease patient. SAGE Open Med Case Rep. 2018;6:2050313X18799247. doi:10.1177/2050313X18799247. https://doi.org/10.1177/2050313X18799247...
,3838 Tokmaji G, Gosev I, Kumamaru KK, Bolman RM 3rd. Mycotic aneurysm of the aortic arch presenting with left vocal cord palsy. Ann Thorac Surg. 2013;96(1):302-5. doi:10.1016/j.athoracsur.2012.11.033. https://doi.org/10.1016/j.athoracsur.201...
,4242 Zangirolami AC, Oliveira FV, Tepedino MS. Ortner's syndrome: secondary laryngeal paralysis caused by a great thoracic aorta aneurysm. Int Arch Otorhinolaryngol. 2015;19(2):180-2. doi:10.1055/s-0034-1397331. https://doi.org/10.1055/s-0034-1397331...
,7373 Wu JT, Lai YF. Hoarseness as a first manifestation of aortotracheal fistula. Am J Emerg Med. 2009;27(8):1019.e1-3. doi:10.1016/j.ajem.2008.12.022. https://doi.org/10.1016/j.ajem.2008.12.0...
]
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8 (10.7) |
Fever/fever of unknown origin[1717 Kalra DK, Zoghbi WA. Hoarseness, hemoptysis and a hole in the aorta: a case review. Echocardiography. 2003;20(3):293-4. doi:10.1046/j.1540-8175.2003.03030.x. https://doi.org/10.1046/j.1540-8175.2003...
,2929 Nakamura Y, Kawachi K, Imagawa H, Watanabe Y, Hamada Y, Tsunooka N. Mycotic aneurysm of the aortic arch due to salmonella. Jpn J Thorac Cardiovasc Surg. 2003;51(6):253-5. doi:10.1007/s11748-003-0024-5. https://doi.org/10.1007/s11748-003-0024-...
,3737 Tanyaowalak W, Sunthornyothin S, Luengtaviboon K, Suankratay C, Kulwichit W. Mycotic aneurysm caused by burkholderia pseudomallei with negative blood cultures. Scand J Infect Dis. 2004;36(1):68-70. doi:10.1080/00365540310017465. https://doi.org/10.1080/0036554031001746...
,4040 Van Doorn RC, Reekers J, de Mol BA, Obertop H, Balm R. Aortoesophageal fistula secondary to mycotic thoracic aortic aneurysm: endovascular repair and transhiatal esophagectomy. J Endovasc Ther. 2002;9(2):212-7. doi:10.1177/152660280200900213. https://doi.org/10.1177/1526602802009002...
]
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4 (5.3) |
Weight loss[77 Bozbas SS, Akçay S, Ulu EK, Büyüklü F, Bozbas H. Cardiovocal (ortner's) syndrome: an unusual vascular complication. Türkiye Klinikleri Arch Lung. 2010;11(1):39-41.,2020 Kyaw WA, Lim CY, Khalil MAM, Lim KC, Chong VH, Tan J. A fatal case of Ortner's syndrome and dysphagia aortica secondary to rapidly expanding mycotic thoracic aortic aneurysm in a chronic kidney disease patient. SAGE Open Med Case Rep. 2018;6:2050313X18799247. doi:10.1177/2050313X18799247. https://doi.org/10.1177/2050313X18799247...
,3737 Tanyaowalak W, Sunthornyothin S, Luengtaviboon K, Suankratay C, Kulwichit W. Mycotic aneurysm caused by burkholderia pseudomallei with negative blood cultures. Scand J Infect Dis. 2004;36(1):68-70. doi:10.1080/00365540310017465. https://doi.org/10.1080/0036554031001746...
,4949 Elzamzamy UA, Joharjy IA. Thoracic aortic aneurysm presenting only as vocal cord paralysis. Neurosciences (Riyadh). 2007;12(3):245-8.]
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4 (5.3) |
Hemosputum/hemoptysis[2929 Nakamura Y, Kawachi K, Imagawa H, Watanabe Y, Hamada Y, Tsunooka N. Mycotic aneurysm of the aortic arch due to salmonella. Jpn J Thorac Cardiovasc Surg. 2003;51(6):253-5. doi:10.1007/s11748-003-0024-5. https://doi.org/10.1007/s11748-003-0024-...
,5353 Kochi K, Okada K, Watari M, Orihashi K, Sueda T. Hybrid endovascular stent grafting for aortic arch aneurysm with aortopulmonary fistula. J Thorac Cardiovasc Surg. 2002;123(2):363-4. doi:10.1067/mtc.2002.119061. https://doi.org/10.1067/mtc.2002.119061...
,4848 Che GW, Chen J, Liu LX, Zhou QH. Aortic arch aneurysm rupture into the lung misdiagnosed as lung carcinoma. Can J Surg. 2008;51(4):E91-2.]
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3 (4.0) |
Fatigue[3232 Okada K, Yamanaka K, Sakamoto T, Inoue T, Matsumori M, Kawakami F, et al. In situ total aortic arch replacement for infected distal aortic arch aneurysms with penetrating atherosclerotic ulcer. J Thorac Cardiovasc Surg. 2014;148(5):2096-100. doi:10.1016/j.jtcvs.2014.02.015. https://doi.org/10.1016/j.jtcvs.2014.02....
,6060 Özyurtlu F, Acet H, Bilik MZ, Tasal A. [Ortner's syndrome caused by dissecting aortic aneurysm]. Türk Kardiyol Dern Ars. 2013;41(3):225-7. doi:10.5543/tkda.2013.47935. Turkish. https://doi.org/10.5543/tkda.2013.47935...
]
|
2 (2.7) |
Poor appetite[22 Sarangi PK, Hui P, Sagar HS, Kisku DK, Mohanty J. Combined left recurrent laryngeal nerve and phrenic nerve palsy: a rare presentation of thoracic aortic aneurysm. J Clin Diagn Res. 2017;11(5):TD01-2. doi:10.7860/JCDR/2017/25035.9765. https://doi.org/10.7860/JCDR/2017/25035....
,2020 Kyaw WA, Lim CY, Khalil MAM, Lim KC, Chong VH, Tan J. A fatal case of Ortner's syndrome and dysphagia aortica secondary to rapidly expanding mycotic thoracic aortic aneurysm in a chronic kidney disease patient. SAGE Open Med Case Rep. 2018;6:2050313X18799247. doi:10.1177/2050313X18799247. https://doi.org/10.1177/2050313X18799247...
]
|
2 (2.7) |
Weakness[22 Sarangi PK, Hui P, Sagar HS, Kisku DK, Mohanty J. Combined left recurrent laryngeal nerve and phrenic nerve palsy: a rare presentation of thoracic aortic aneurysm. J Clin Diagn Res. 2017;11(5):TD01-2. doi:10.7860/JCDR/2017/25035.9765. https://doi.org/10.7860/JCDR/2017/25035....
,3737 Tanyaowalak W, Sunthornyothin S, Luengtaviboon K, Suankratay C, Kulwichit W. Mycotic aneurysm caused by burkholderia pseudomallei with negative blood cultures. Scand J Infect Dis. 2004;36(1):68-70. doi:10.1080/00365540310017465. https://doi.org/10.1080/0036554031001746...
]
|
2 (2.7) |
Choking[3939 Tsai WC, Wang CH, Chen HC. Cardiovocal syndrome secondary to a giant aortic arch aneurysm. Eur Geriatr Med. 2015;6(1):63-4. doi:10.1155/2016/9867942. https://doi.org/10.1155/2016/9867942...
]
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1 (1.3) |
Aspiration[3232 Okada K, Yamanaka K, Sakamoto T, Inoue T, Matsumori M, Kawakami F, et al. In situ total aortic arch replacement for infected distal aortic arch aneurysms with penetrating atherosclerotic ulcer. J Thorac Cardiovasc Surg. 2014;148(5):2096-100. doi:10.1016/j.jtcvs.2014.02.015. https://doi.org/10.1016/j.jtcvs.2014.02....
]
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1 (1.3) |
Nasal obstruction[55 Ali Shah MU, Siddiqi R, Chaudhri MS, Khan AA, Chaudhry I. Aortic aneurysm: a rare cause of Ortner's syndrome. J Coll Physicians Surg Pak. 2014;24(4):282-4.]
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1 (1.3) |
Sore throat[55 Ali Shah MU, Siddiqi R, Chaudhri MS, Khan AA, Chaudhry I. Aortic aneurysm: a rare cause of Ortner's syndrome. J Coll Physicians Surg Pak. 2014;24(4):282-4.]
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1 (1.3) |
Sputum[3131 Ohki M. Thoracic saccular aortic aneurysm presenting with recurrent laryngeal nerve palsy prior to aneurysm rupture: a prodrome of thoracic aneurysm rupture? Case Rep Otolaryngol. 2012;2012:367873. doi:10.1155/2012/367873. https://doi.org/10.1155/2012/367873...
]
|
1 (1.3) |
Dizziness[5757 Lin WS, Cheng CA. Ortner's syndrome. Acta Neurol Taiwan. 2011;20(4):281-2.]
|
1 (1.3) |
Headache[5757 Lin WS, Cheng CA. Ortner's syndrome. Acta Neurol Taiwan. 2011;20(4):281-2.]
|
1 (1.3) |
Orthopnea[5252 Joseph TK, Nair R. Combined recurrent laryngeal and phrenic nerve paralysis due to aortic arch aneurysm. Int J Phonosurg Laryngol. 2013;3(2):58-60. doi:10.5005/jp-journals-10023-1064. https://doi.org/10.5005/jp-journals-1002...
]
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1 (1.3) |
Claudication pain in the legs[5252 Joseph TK, Nair R. Combined recurrent laryngeal and phrenic nerve paralysis due to aortic arch aneurysm. Int J Phonosurg Laryngol. 2013;3(2):58-60. doi:10.5005/jp-journals-10023-1064. https://doi.org/10.5005/jp-journals-1002...
]
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1 (1.3) |
Shock[4444 Abd Samat AH, Embong H. Ortner's syndrome: focused cardiac ultrasound and rapid ultrasound in shock examination at emergency department unfold the life-threatening cause for a cardiovocal condition. Hong Kong J Emerg Med. 2018;25(5):293-7. doi:10.1177/1024907918755163. https://doi.org/10.1177/1024907918755163...
]
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1 (1.3) |