Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in mice

Abstract

The ethanolic extract (EE) of Acosmium subelegans (Mohlenbr) Yakovl (perobinha-do-campo) was tested to behavioral paradigms in mice to investigate its putative central depressant effect. Oral pretreatment with the EE significantly reduced in a dose-dependent way the locomotor activity and increased by 30-55% the barbiturate sleep duration relatively to control values. At the highest dose (1,0 g.kg-1) it decreased the extension time/flexion time ratio of the maximal electroshockinduced convulsions, enhanced the latency to the pentylenetetrazol-induced convulsions and diminished by 26% the number of seizures, indicating an anticonvulsant action. No changes were observed in the motor coordination, the core temperature, climbing behavior, catalepsy and the plus-maze performance. The preliminary results indicate that the EE of A. subelegans induce a CNS depressant effect, more specifically an anticonvulsant effect that deserve a thorough investigation.


Evaluation of the central activity of the ethanolic extract of Acosmium subelegans (Mohlenbr) in mice

Ricardo A. VieiraI; Antonio J. LapaII; Thereza C. M. de LimaI, * * thereza@farmaco.ufsc.br

ILaboratory of Neuropharmacology, Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, 88015-420, Florianópolis, SC

IINatural Products Section, Department of Pharmacology, Escola Paulista de Medicina, UNIFESP, 04044-020, São Paulo, SP, Brazil

ABSTRACT

The ethanolic extract (EE) of Acosmium subelegans (Mohlenbr) Yakovl (perobinha-do-campo) was tested to behavioral paradigms in mice to investigate its putative central depressant effect. Oral pretreatment with the EE significantly reduced in a dose-dependent way the locomotor activity and increased by 30-55% the barbiturate sleep duration relatively to control values. At the highest dose (1,0 g.kg-1) it decreased the extension time/flexion time ratio of the maximal electroshockinduced convulsions, enhanced the latency to the pentylenetetrazol-induced convulsions and diminished by 26% the number of seizures, indicating an anticonvulsant action. No changes were observed in the motor coordination, the core temperature, climbing behavior, catalepsy and the plus-maze performance. The preliminary results indicate that the EE of A. subelegans induce a CNS depressant effect, more specifically an anticonvulsant effect that deserve a thorough investigation.

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Acknowledgments

This work was supported by grants from Central de Medicamentos (CEME - MS) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). R. A. Vieira was a recipient of a fellowship from CAPES (MSc); A J. Lapa and T.C.M. De Lima are recipients of research grants from CNPq.

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Publication Dates

  • Publication in this collection
    05 Oct 2009
  • Date of issue
    2002
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