Bioactivity-guided fractions of the methanol extract from the roots of Andira anthelmia led the isolation of the isoflavones biochanin A and genistein from the ethyl acetate fraction; biochanin A 7-O-β-D-glucopyranoside, biochanin A 7-O-α-L-rhamnopyranosyl-(1→6)β-D-glucopyranoside and biochanin A 7-O-β-D-apiofuranosyl-(1→5)-β-D-apiofuranosyl-(1→6)β-D-glucopyranoside from the n-butanol fraction and catechin from the methanol one. Their structures were elucidated on the basis of spectroscopy data. The anthelmintic activity was investigated in mice naturally infected by Aspiculuris tetraptera. The compounds administered in the animals by intragastric route in doses of 2.0 mg.kg-1, were effective in the removal of the total number of the A. tetraptera when compared with the control group.
Andira anthelmia; Flavonoids; Anthelmintic activity
