Estudo físico-químico, químico e biológico de extrato das cascas de Stryphnodendron polyphyllum Mart. (Leguminosae)

Resumo

Two flavan-3-ols and one proanthocyanidins have been isolated from the stem bark of Stryphnodendron polyphyllum Mart., which is traditionally used in Brazil against various diseases. The structure was determined on the basis of spectroscopic data including 1-D (¹H, 13C) and 2-D NMR (¹H/¹H COSY) and MS. The antibacterial activities of an acetone:water and semipurified extracts from the stem bark of Stryphnodendron polyphyllum Mart. were evaluated. Both the crude and semipurified extracts showed activity against Bacillus subtilis and Staphylococcus aureus. Quality control was determined using several pharmacopoeial assay.


Estudo físico-químico, químico e biológico de extrato das cascas de Stryphnodendron polyphyllum Mart. (Leguminosae)

Lopes, G.C.; Nakamura, C.V.; Dias Filho, B.P.; Mello, J.C.P.* * Autor para correspondência: Prof. Dr. João Carlos Palazzo de Mello Departamento de Farmácia e Farmacologia Universidade Estadual de Maringá Av. Colombo, 5790 87020-900 - Maringá - PR E-mail: mello@uem.br

Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá, PR

ABSTRACT

Two flavan-3-ols and one proanthocyanidins have been isolated from the stem bark of Stryphnodendron polyphyllum Mart., which is traditionally used in Brazil against various diseases. The structure was determined on the basis of spectroscopic data including 1-D (1H, 13C) and 2-D NMR (1H/1H COSY) and MS. The antibacterial activities of an acetone:water and semipurified extracts from the stem bark of Stryphnodendron polyphyllum Mart. were evaluated. Both the crude and semipurified extracts showed activity against Bacillus subtilis and Staphylococcus aureus. Quality control was determined using several pharmacopoeial assay.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

  • *
    Autor para correspondência:
    Prof. Dr. João Carlos Palazzo de Mello
    Departamento de Farmácia e Farmacologia
    Universidade Estadual de Maringá
    Av. Colombo, 5790
    87020-900 - Maringá - PR
    E-mail:
    • 1 Pio Correia, M. Dicionário das plantas úteis do Brasil e das exóticas cultivadas. Rio de Janeiro: Imprensa Oficial, 1926. p.1.
    • 2 Mello, J.C.P. de; Petereit, F.; Nahrstedt, A. Flavan-3-ols and prodelphinidins from Stryphnodendron adstringens Phytochemistry (New York), v.41, n.3, p.807-813, 1996a.
    • 3 Panizza, S.; Rocha, A.B.; Gecchi, R.; Silva,R.A.P. de S. Stryphnodendron barbadetiman (Vellozo) Martius: teor em tanino na casca e sua propriedade cicatrizante. Rev. Cięnc. Farm. (Araraquara), v.10, p.101-106, 1988.
    • 4 Lima, J.C.S.; Martins, D.T.O.; de Souza Jr, P.T. Experimental evaluation of stem bark of Stryphnodendron adstringens (Mart.) Coville for antiinflammatory activity. Phytother. Res. (London), v.12, p.218-220, 1998.
    • 5 Audi, E.A.; Toledo, D.P.; Peres, P.G.; Kimura, E.; Pereira, W.K.V.; Mello, J.C.P.de; Nakamura, C.V.; Alves-do-Prado, W.; Cuman, R.K.N.; Bersani-Amado, C.A. Gastric antiulcerogenic effects of Stryphnodendron adstringens in rats. Phytother. Res. (London), v.13, p.264-266, 1999.
    • 6 Mello, J.C.P.de; Petereit, F.; Nahrstedt, A. Prorobinetinidins from Stryphnodendron adstringens Phytochemistry (New York), v.42, n.3, p.857-862, 1996b.
    • 7 Czech, E.; Kneifel, W.; Kopp, B. Microbiological status of commercially available medicinal herbal drugs - a screening study. Planta Med. (Sttutgard), v.67, p.263-269, 2001.
    • 8 Holetz, F.B.; Pessini, G.L.; Sanches, N.R.; Cortez, D.A.G.; Nakamura, C.V.; Dias Filho, B.P. Screening of some plants used in the Brazilian folk medicine for the treatment of infectious diseases. Mem. Inst. Oswaldo Cruz (Rio de Janeiro), v.97, n.7, p.1027-1031, 2002.
    • 9 Farias, M.R. Avaliaçăo da qualidade de matérias-primas vegetais. In: Simőes, C.M.O.; Schenkel, E.P.; Gosmann, G.; Mello, J.C.P.de; Mentz, L.A.; Petrovick, P.R. Farmacognosia: da planta ao medicamento. 4.ed. Porto Alegre/Florianópolis: Ed. Universidade UFRGS/Ed. UFSC, cap.10, 2002. p.165-182.
    • 10 Guangcheng, Z.; Yunlu, L.; Yazaki, Y. Extractive yiels. Stiasny values and polyflavonoid content in barks from six acacia species in Australia. Aust. Forestry (Queen Victoria), v.54, p.154-156, 1991.

    * Autor para correspondência: Prof. Dr. João Carlos Palazzo de Mello Departamento de Farmácia e Farmacologia Universidade Estadual de Maringá Av. Colombo, 5790 87020-900 - Maringá - PR E-mail: mello@uem.br

    Datas de Publicação

    • Publicação nesta coleção
      25 Set 2009
    • Data do Fascículo
      2003
    Sociedade Brasileira de Farmacognosia Universidade Federal do Paraná, Laboratório de Farmacognosia, Rua Pref. Lothario Meissner, 632 - Jd. Botânico, 80210-170, Curitiba, PR, Brasil, Tel/FAX (41) 3360-4062 - Curitiba - PR - Brazil
    E-mail: revista@sbfgnosia.org.br