Alcalóides de Duguetia trunciflora Maas (Annonaceae)

Fechine, I.M.; Lima, M.A.; Navarro, V.R.; Cunha, E.V. L. da; Silva, M.S.; Barbosa-Filho, J.M.; Maia, J.G.S.

doi:10.1590/S0102-695X2002000300009

Resumo

From the ethanolic extract of the leaves and thin branches of Duguetia trunciflora Maas (Annonaceae) six alkaloids were isolated, being one benzylisoquinoline: reticuline¹, four tetrahydroprotoberberine:,tetrahydro-palmatine², tetrahydrojathrorrizine³, discretamine4, thaicanine5, and one berberine: jathrorrizine6. These alkaloids were identified through ¹H and 13C NMR spectroscopic technics. The alkaloids 1, 3, 5 and 6 are being cited for the first time on Duguetia genus.

Alcalóides de Duguetia trunciflora Maas (Annonaceae)

I.M. Fechine^I; M.A. Lima^I; V.R. Navarro^I; E.V. L. da Cunha^I,II; M.S. Silva^I; J.M. Barbosa-FilhoI,^* * jbarbosa@ltf.ufpb.br ; J.G.S. Maia^III

^ILaboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, CP 5009, 58051-970, João Pessoa, PB, Brasil

^IIUniversidade Estadual da Paraíba, Departamento de Farmácia e Biologia, Campina Grande, PB, Brasil.

^IIIDepartamento de Botânica, Museu Paraense Emílio Goeldi, CP 399, 66040-170, Belém, PA

ABSTRACT

From the ethanolic extract of the leaves and thin branches of Duguetia trunciflora Maas (Annonaceae) six alkaloids were isolated, being one benzylisoquinoline: reticuline¹, four tetrahydroprotoberberine:,tetrahydro-palmatine², tetrahydrojathrorrizine³, discretamine⁴, thaicanine⁵, and one berberine: jathrorrizine⁶. These alkaloids were identified through ¹H and ¹³C NMR spectroscopic technics. The alkaloids 1, 3, 5 and 6 are being cited for the first time on Duguetia genus.

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Agradecimentos

Os autores agradecem ao Banco de Dados NAPRALERT, da Universidade de Illinois, USA, pelo levantamento bibliográfico e ao CNPq e CAPES pelo apoio financeiro.

1 Hutchinson J. The genera of flowering plants. Clarendon Press, Oxford, 1964. p. 71-108
2 Ribeiro JEL. Flora da Reserva Duck: Guia de identificaçăo das plantas vasculares de uma floresta de terra firme na Amazônia Central. INPA, Manaus, 1999. 816p
3 Sette IMF, Da-Cunha EVL, Barbosa-Filho JM, Silva MS. Tetrahydroprotoberberine and aporphine alkaloids from Rollinia leptopetala Pharmaceutical Biology 2000; 38: 318-320
4 Navarro VR, Sette IMF, Da-Cunha EVL, Silva MS, Barbosa-Filho JM, Maia JGS. Alcalóides de Duguetia flagellaris Huber (Annonaceae). Revista Brasileira de Plantas Medicinais 2001 (No prelo)
5 Hussain AR, Kim J, Beecher WWC, Kinghprn DA. Unambiguous carbon-13 NMR assignments of some biologicaly active protoberberine alkalois. Heterocycles 1989; 29: 2257-2260
6 Bhakuni DS, Gupta S. The alkaloids of Stephania glabra J. Nat. Prod. 1982; 45: 406-411
7 Chang HM, El-Fishawy AM, Slatkin DJ, Schiff-Junior PL. Quaternary alkaloids of Tinospora capillipes Planta Medica 1984; 88-90
8 Ohiri FC, Verpoorte R, Baerheim-Svendsen A. 1H NMR chemical shifts values for aromatic prótons in 2, 3, 9, 10- and 2, 3, 10, 11-tetrasubstituted tetrahydroprotoberberine alkaloids. Planta Medica 1983; 49: 162-164

*

jbarbosa@ltf.ufpb.br

Datas de Publicação

Publicação nesta coleção
05 Out 2009
Data do Fascículo
2002

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

[1] 1 Hutchinson J. The genera of flowering plants. Clarendon Press, Oxford, 1964. p. 71-108

[2] 2 Ribeiro JEL. Flora da Reserva Duck: Guia de identificaçăo das plantas vasculares de uma floresta de terra firme na Amazônia Central. INPA, Manaus, 1999. 816p

[3] 3 Sette IMF, Da-Cunha EVL, Barbosa-Filho JM, Silva MS. Tetrahydroprotoberberine and aporphine alkaloids from Rollinia leptopetala Pharmaceutical Biology 2000; 38: 318-320

[4] 4 Navarro VR, Sette IMF, Da-Cunha EVL, Silva MS, Barbosa-Filho JM, Maia JGS. Alcalóides de Duguetia flagellaris Huber (Annonaceae). Revista Brasileira de Plantas Medicinais 2001 (No prelo)

[5] 5 Hussain AR, Kim J, Beecher WWC, Kinghprn DA. Unambiguous carbon-13 NMR assignments of some biologicaly active protoberberine alkalois. Heterocycles 1989; 29: 2257-2260

[6] 6 Bhakuni DS, Gupta S. The alkaloids of Stephania glabra J. Nat. Prod. 1982; 45: 406-411

[7] 7 Chang HM, El-Fishawy AM, Slatkin DJ, Schiff-Junior PL. Quaternary alkaloids of Tinospora capillipes Planta Medica 1984; 88-90

[8] 8 Ohiri FC, Verpoorte R, Baerheim-Svendsen A. 1H NMR chemical shifts values for aromatic prótons in 2, 3, 9, 10- and 2, 3, 10, 11-tetrasubstituted tetrahydroprotoberberine alkaloids. Planta Medica 1983; 49: 162-164