Vanillosmopsis erythropappa is a plant rich in essential oils, especially á-bisabolol. The aim of this study was research the qualitative seasonal variation of natural substances, tenor of essential oils, total ashes, dampness and pH. The results showed a variation of the flavonoids, tannins, triterpenoids, steroids, saponins, essential oils, total ashes, dampness and pH, demonstrating that environmental aspects influence on the metabolism of this specie. The annual averages of the obtained values were: essential oils = 0,29 ± 0,09%; total ashes = 3,13 ± 0,49%; dampness= 6,56 ± 0,80% and pH = 5,40 ± 0,24.