Vaginal delivery
|
RR PPH carbetocin |
0.950 |
0.430 |
2.090 |
|
Boucher et al. (2004)2121 Boucher M, Nimrod CA, Tawagi GF, Meeker TA, RennicksWhite RE, Varin J. Comparison of carbetocin and oxytocin for the prevention of postpartum hemorrhage following vaginal delivery:a doubleblind randomized trial. J Obstet Gynaecol Can 2004;26(05): 481-488. Doi: 10.1016/S1701-2163(16)30659-4 https://doi.org/10.1016/S1701-2163(16)30...
|
Probability of PPH in oxytocin group |
0.164 |
0.074 |
0.361 |
Beta |
Boucher et al. (2004)2121 Boucher M, Nimrod CA, Tawagi GF, Meeker TA, RennicksWhite RE, Varin J. Comparison of carbetocin and oxytocin for the prevention of postpartum hemorrhage following vaginal delivery:a doubleblind randomized trial. J Obstet Gynaecol Can 2004;26(05): 481-488. Doi: 10.1016/S1701-2163(16)30659-4 https://doi.org/10.1016/S1701-2163(16)30...
|
Probability of PPH in carbetocin group |
0.156 |
0.071 |
0.343 |
Beta |
Calculated |
Probability of death by hemorrhagic event |
0.003 |
0.000 |
0.031 |
Beta |
INS33 de Salud M, Social P. Instituto Nacional de Salud. Sistema Nacional de Vigilancia en Salud Pública: Informes de Evento. 2016. http://www.ins.gov.co/lineas-de-accion/Subdireccion-Vigilancia/Paginas/ informes-de-evento.aspx. Accessed July 11, 2017 http://www.ins.gov.co/lineas-de-accion/S...
Sheldon et al. (2014)2020 SheldonWR, Blum J, Vogel JP, Souza JP, Gülmezoglu AM,Winikoff B; WHO Multicountry Survey on Maternal and Newborn Health Research Network. Postpartum haemorrhage management, risks, and maternal outcomes: findings from the World Health Organization Multicountry Survey on Maternal and Newborn Health. BJOG 2014;121(Suppl 1):5-13. Doi: 10.1111/1471-0528.12636 https://doi.org/10.1111/1471-0528.12636...
|
RR use of additional uterotonics carbetocin |
0.930 |
0.440 |
1.940 |
|
Boucher et al. (2004)2121 Boucher M, Nimrod CA, Tawagi GF, Meeker TA, RennicksWhite RE, Varin J. Comparison of carbetocin and oxytocin for the prevention of postpartum hemorrhage following vaginal delivery:a doubleblind randomized trial. J Obstet Gynaecol Can 2004;26(05): 481-488. Doi: 10.1016/S1701-2163(16)30659-4 https://doi.org/10.1016/S1701-2163(16)30...
|
Probability use of additional uterotonics oxytocin |
0.156 |
0.074 |
0.325 |
Beta |
Boucher et al. (2004)2121 Boucher M, Nimrod CA, Tawagi GF, Meeker TA, RennicksWhite RE, Varin J. Comparison of carbetocin and oxytocin for the prevention of postpartum hemorrhage following vaginal delivery:a doubleblind randomized trial. J Obstet Gynaecol Can 2004;26(05): 481-488. Doi: 10.1016/S1701-2163(16)30659-4 https://doi.org/10.1016/S1701-2163(16)30...
|
Probability use of additional uterotonics carbetocin |
0.145 |
0.069 |
0.302 |
Beta |
Calculated |
Caesarean section
|
RR PPH carbetocin |
0.520 |
0.290 |
0.930 |
|
Borruto et al. (2009)2222 Borruto F, Treisser A, Comparetto C. Utilization of carbetocin for prevention of postpartum hemorrhage after cesarean section: a randomized clinical trial. Arch Gynecol Obstet 2009;280(05): 707-712. Doi: 10.1007/s00404-009-0973-8 https://doi.org/10.1007/s00404-009-0973-...
|
Probability of PPH in oxytocin group |
0.442 |
0.247 |
0.791 |
Beta |
Borruto et al. (2009)2222 Borruto F, Treisser A, Comparetto C. Utilization of carbetocin for prevention of postpartum hemorrhage after cesarean section: a randomized clinical trial. Arch Gynecol Obstet 2009;280(05): 707-712. Doi: 10.1007/s00404-009-0973-8 https://doi.org/10.1007/s00404-009-0973-...
|
Probability of PPH in carbetocin group |
0.230 |
0.128 |
0.411 |
Beta |
Calculated |
Probability of death by hemorrhagic event |
0.008 |
0.000 |
0.031 |
Beta |
INS33 de Salud M, Social P. Instituto Nacional de Salud. Sistema Nacional de Vigilancia en Salud Pública: Informes de Evento. 2016. http://www.ins.gov.co/lineas-de-accion/Subdireccion-Vigilancia/Paginas/ informes-de-evento.aspx. Accessed July 11, 2017 http://www.ins.gov.co/lineas-de-accion/S...
Sheldon et al. (2014)2020 SheldonWR, Blum J, Vogel JP, Souza JP, Gülmezoglu AM,Winikoff B; WHO Multicountry Survey on Maternal and Newborn Health Research Network. Postpartum haemorrhage management, risks, and maternal outcomes: findings from the World Health Organization Multicountry Survey on Maternal and Newborn Health. BJOG 2014;121(Suppl 1):5-13. Doi: 10.1111/1471-0528.12636 https://doi.org/10.1111/1471-0528.12636...
|
RR use of additional uterotonics carbetocin |
0.700 |
0.510 |
0.980 |
|
Borruto et al. (2009)2222 Borruto F, Treisser A, Comparetto C. Utilization of carbetocin for prevention of postpartum hemorrhage after cesarean section: a randomized clinical trial. Arch Gynecol Obstet 2009;280(05): 707-712. Doi: 10.1007/s00404-009-0973-8 https://doi.org/10.1007/s00404-009-0973-...
Attilakos et al. (2010)2323 Attilakos G, Psaroudakis D, Ash J, et al. Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a double-blind randomised trial. BJOG 2010;117(08):929-936. Doi: 10.1111/j.1471-0528.2010.02585.x https://doi.org/10.1111/j.1471-0528.2010...
|
Probability use of additional uterotonics oxytocin |
0.374 |
0.272 |
0.524 |
Beta |
Borruto et al. (2009)2222 Borruto F, Treisser A, Comparetto C. Utilization of carbetocin for prevention of postpartum hemorrhage after cesarean section: a randomized clinical trial. Arch Gynecol Obstet 2009;280(05): 707-712. Doi: 10.1007/s00404-009-0973-8 https://doi.org/10.1007/s00404-009-0973-...
Attilakos et al. (2010)2323 Attilakos G, Psaroudakis D, Ash J, et al. Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a double-blind randomised trial. BJOG 2010;117(08):929-936. Doi: 10.1111/j.1471-0528.2010.02585.x https://doi.org/10.1111/j.1471-0528.2010...
|
Probability use of additional uterotonics carbetocin |
0.262 |
0.191 |
0.367 |
Beta |
Calculated |
Vaginal and cesarean delivery
|
Requirement for first-line surgical intervention (tamponade and hemostatic suture) |
0.100 |
0.000 |
0.120 |
Beta |
Experts |
Requirement for second line surgical intervention (hysterectomy) |
0.010 |
0.000 |
0.050 |
Beta |
Experts |
Surgical approach
|
Proportion of patients undergoing uterine tamponade |
0.60 |
|
|
|
Experts |
Proportion of patients undergoing hemostatic suture |
0.40 |
|
|
|
Experts |
Frequency of complications of uterine tamponade
|
Infection |
0.02 |
|
|
|
Experts |
Frequency of complications of hemostatic suture B-Lynch
|
Ureteral injury |
0.002 |
|
|
|
Experts |
Bladder injury |
0.001 |
|
|
|
Experts |
Intestinal injury |
0.001 |
|
|
|
Experts |
Frequency of hysterectomy complications
|
Infection |
0.02 |
|
|
|
Experts |
Ureteral injury |
0.01 |
|
|
|
Experts |
Bladder injury |
0.01 |
|
|
|
Experts |
Intestinal injury |
0.005 |
|
|
|
Experts |
Utilities
|
Vaginal delivery utility (Non-PPH) |
0.9997 |
0.9996 |
0.9998 |
Triangular |
2424 Plunkett BA, Grobman WA. Routine hepatitis C virus screening in pregnancy: a cost-effectiveness analysis. Am J Obstet Gynecol 2005;192(04):1153-1161. Doi: 10.1016/j.ajog.2004.10.600 https://doi.org/10.1016/j.ajog.2004.10.6...
|
Caesarean section utility (No PPH) |
0.9996 |
0.9995 |
0.9997 |
Triangular |
2424 Plunkett BA, Grobman WA. Routine hepatitis C virus screening in pregnancy: a cost-effectiveness analysis. Am J Obstet Gynecol 2005;192(04):1153-1161. Doi: 10.1016/j.ajog.2004.10.600 https://doi.org/10.1016/j.ajog.2004.10.6...
|
PPH (First Line Treatment) Utility - vaginal delivery |
0.9918 |
0.9913 |
0.9922 |
Triangular |
2525 Fawsitt CG, Bourke J, Greene RA, Everard CM, Murphy A, Lutomski JE. At what price? A cost-effectiveness analysis comparing trial of labour after previous caesarean versus elective repeat caesarean delivery. PLoS One 2013;8(03):e58577. Doi: 10.1371/journal. pone.0058577 https://doi.org/10.1371/journal...
|
PPH (First Line Treatment) Utility - Caesarean section |
0.9917 |
0.9912 |
0.9921 |
Triangular |
2525 Fawsitt CG, Bourke J, Greene RA, Everard CM, Murphy A, Lutomski JE. At what price? A cost-effectiveness analysis comparing trial of labour after previous caesarean versus elective repeat caesarean delivery. PLoS One 2013;8(03):e58577. Doi: 10.1371/journal. pone.0058577 https://doi.org/10.1371/journal...
|
Disutility by endometritis |
0.0144 |
0.0132 |
0.0155 |
Triangular |
2525 Fawsitt CG, Bourke J, Greene RA, Everard CM, Murphy A, Lutomski JE. At what price? A cost-effectiveness analysis comparing trial of labour after previous caesarean versus elective repeat caesarean delivery. PLoS One 2013;8(03):e58577. Doi: 10.1371/journal. pone.0058577 https://doi.org/10.1371/journal...
|
Disutility due to operative injury |
0.0303 |
0.0280 |
0.0326 |
Triangular |
2525 Fawsitt CG, Bourke J, Greene RA, Everard CM, Murphy A, Lutomski JE. At what price? A cost-effectiveness analysis comparing trial of labour after previous caesarean versus elective repeat caesarean delivery. PLoS One 2013;8(03):e58577. Doi: 10.1371/journal. pone.0058577 https://doi.org/10.1371/journal...
|
Hysterectomy disutility |
0.0334 |
0.0306 |
0.0363 |
Triangular |
2525 Fawsitt CG, Bourke J, Greene RA, Everard CM, Murphy A, Lutomski JE. At what price? A cost-effectiveness analysis comparing trial of labour after previous caesarean versus elective repeat caesarean delivery. PLoS One 2013;8(03):e58577. Doi: 10.1371/journal. pone.0058577 https://doi.org/10.1371/journal...
|