Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region

Martins, Luís Felipe Leite; Moreira, Miguel Ângelo Martins; Pinto, Rodrigo Alves; Reis, Neilane Bertoni dos; Felix, Shayany Pinto; Vidal, João Paulo Castello Branco; Torres, Leuridan Cavalcante; Souza, Ariani Impieri; Almeida, Liz Maria de

doi:10.1055/s-0043-1772180

home Sumário navigate_before Anterior Atual Seguinte navigate_next

home Sumário

Original Article • Rev Bras Ginecol Obstet 45 (8) • 2023 • https://doi.org/10.1055/s-0043-1772180 linkcopy

Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region

Papillomavirus humano 16 da linhagem D associado a alto risco de câncer de colo do útero em região do nordeste brasileiro

Authorship SCIMAGO INSTITUTIONS RANKINGS

Abstract

Objective Similar to Human Papillomavirus (HPV) genotypes, different lineages of a genotype also have different carcinogenic capabilities. Studies have shown that specific genotype lineages of oncogenic HPV are associated with variable risks for the development of cervical intraepithelial neoplasia (CIN2/CIN3) and cervical cancer. The present study aimed to analyze the genetic diversity of the HPV16 genotype in women with CIN2/CIN3 and cervical cancer, from the northeast region of Brazil.

Methods A cross-sectional multicenter study was conducted in the northeast region of Brazil, from 2014 to 2016. This study included 196 cases of HPV16 variants (59 and 137 cases of CIN2/CIN3 and cervical cancer, respectively). The difference of proportion test was used to compare patients with CIN2/CIN3 and cervical cancer, based on the prevalent HPV16 lineage (p < 0.05).

Results According to the histopathological diagnosis, the percentage of lineage frequencies revealed a marginal difference in the prevalence of lineage A in CIN2/CIN3, compared with that in cervical cancer (p = 0.053). For lineage D, the proportion was higher in cancer cases (32.8%), than in CIN2/CIN3 cases (16.9%), with p = 0.023.

Conclusion HPV16 lineage A was the most frequent lineage in both CIN2/CIN3 and cervical cancer samples, while lineage D was predominant in cervical cancer, suggesting a possible association between HPV16 lineage D and cervical cancer.

Keywords
HPV16; lineage A; lineage D; CIN2/CIN3; cervical cancer

Variable		CIN2/CIN3		Cervical cancer		p-value *
Variable		n = 59	%	n = 137	%	p-value *
Age (years old)
	20–39	37	62.7	43	31.4	< 0.001
	40–49	16	27.1	40	29.2
	50–59	6	10.2	23	16.8
	≥ 60	0	0.0	31	22.6
Number of childbirths
	None	3	5.1	3	2.2
	1–2	28	47.5	43	31.4	0.07
	3–4	17	28.8	44	32.1
	5–6	5	8.5	14	10.2
	≥ 7	6	10.1	33	24.1
Oral contraceptive use
	Yes	42	71.2	88	64.2	0.34
	No	17	28.8	49	35.8
Tobacco exposure
	Yes	26	44.1	76	55.5	0.14
	No	33	55.9	61	44.5

HPV16 lineages	Histopatological diagnosis					p-value *
	Total	CIN2/CIN3		Cervical Cancer
	n (%)	n	%	n	%
A	130 (66.3)	45	76.3	85	62.0	0.053
B/C	11 (5.6)	4	6.8	7	5.1	0.635
D	55 (28.1)	10	16.9	45	32.8	0.023

vertical_align_top show_chart

more_horiz close
- image
- translate
- link
- article
- vertical_align_top
- file_download
- show_chart
- image
- translate
- link
- article

location_on

Federação Brasileira das Sociedades de Ginecologia e Obstetrícia Av. Brigadeiro Luís Antônio, 3421, sala 903 - Jardim Paulista, 01401-001 São Paulo SP - Brasil, Tel. (55 11) 5573-4919 - Rio de Janeiro - RJ - Brazil
E-mail: editorial.office@febrasgo.org.br

rss_feed Acompanhe os números deste periódico no seu leitor de RSS

[TFN1] Abbraviation: CIN, cervical intraepithelial neoplasia.

[TFN2] ^*
Chi-squared test or Fisher exact test.