#1Wang et al., 77 Wang S, Guo L, Chen L, LiuW, Cao Y, Zhang J, Feng L. A case report of neonatal 2019 Coronavirus Disease in China. Clin Infect Dis. 2020;71(15):853-857. Doi: 10.1093/cid/ciaa225 https://doi.org/10.1093/cid/ciaa225...
Hu et al., 88 Hu X, Gao J, Luo X, Feng L, Liu W, Chen J, et al. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) vertical transmission in neonates born to mothers with Coronavirus Disease 2019 (COVID-19) pneumonia. Obstet Gynecol. 2020; 136(01):65-67. Doi: 10.1097/AOG.0000000000003926 https://doi.org/10.1097/AOG.000000000000...
Yu et al. 99 Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, et al. Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study. Lancet Infect Dis. 2020;20(05):559-564. Doi:10.1016/S1473-3099(20)30176-6 https://doi.org/10.1016/S1473-3099(20)30...
|
China; Wuhan; Tongji Hospital |
34 |
39 weeks 6 days |
3,250 g |
8/9 |
Cesarean |
Positive RT-PCR in th oropharynx swab – newborn 36 hours after delivery. |
8 hours of maternal symptoms + 36 hours postpartum |
Not justified: RT-PCR the in oropharynx swab collected after more than 12 hours of delivery. |
#2Dong et al. 1010 Dong L, Tian J, He S, Zhu C, Wang J, Liu C, Yang J. Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA. 2020;323(18):1846-1848. Doi: 10.1001/jama.2020.4621 https://doi.org/10.1001/jama.2020.4621...
|
China; Wuhan; Renmin Hospitalof Wuhan University |
29 |
37weeks 6 days |
3,120 g |
9/10 |
Cesarean |
Positive IgM and IgG 2 hours after delivery;negative RT-PCR in the oropharynx swab;IgM and IgG levels were reduced after 2 weeks;discharged. |
25 days |
Not justified: discordance among exams and negative RT-PCR in the oropharynx swab. |
#3Zamaniyan et al. 1111 Zamaniyan M, Ebadi A, Aghajanpoor Mir S, Rahmani Z, Haghshenas M, Azizi S. Preterm delivery, maternal death, and vertical transmission in a pregnant woman with COVID-19 infection. Prenat Diagn. 2020 [ahead of print]
|
Iran; Sari; Imam Khomeini Hospital |
22 |
32 weeks |
2,350 g |
8/9 |
Cesarean |
Positive RT-PCR in the amniotic fluid collected during cesarean section (contamination?); negative RT-PCR in the oropharynx swab of the newborn; maternal death postpartum. |
7 days |
Not justified: positive RT-PCR in the amniotic fluid, but with the possibility of contamination with no other confirmation of the virus. |
#4Li et al. 55 Li N, Han L, Peng M, Lv Y, Ouyang Y, Liu K, et al. Maternal and Neonatal Outcomes of Pregnant Women With Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case-Control Study. Clin Infect Dis. 2020;71(16):2035-2041 and Ferrazzi et al. 1212 Ferrazzi E, Frigerio L, Savasi V, Vergani P, Prefumo F, Barresi S, et al. Vaginal delivery in SARS-CoV-2-infected pregnant women in Northern Italy: a retrospective analysis. BJOG. 2020;127(09): 1116-1121. Doi: 10.1111/1471-0528.16278 https://doi.org/10.1111/1471-0528.16278...
|
China; Wuhan; Hubei Provincial Maternal and Child Health Center; 55 Li N, Han L, Peng M, Lv Y, Ouyang Y, Liu K, et al. Maternal and Neonatal Outcomes of Pregnant Women With Coronavirus Disease 2019 (COVID-19) Pneumonia: A Case-Control Study. Clin Infect Dis. 2020;71(16):2035-2041 and Italy; Lombardy and Units of Padua and Modena 1212 Ferrazzi E, Frigerio L, Savasi V, Vergani P, Prefumo F, Barresi S, et al. Vaginal delivery in SARS-CoV-2-infected pregnant women in Northern Italy: a retrospective analysis. BJOG. 2020;127(09): 1116-1121. Doi: 10.1111/1471-0528.16278 https://doi.org/10.1111/1471-0528.16278...
|
NR |
NR |
NR |
NR |
Vaginal |
Positive RT-PCR in two newborns. In these two cases, because viral testing was not performed immediately after birth, postpartum transmission cannot be excluded. |
Not informed |
Not justified: the swab test was not performed shortly after birth. |
#6Alzamora et al. 1313 AlzamoraMC, Paredes T, Caceres D,Webb CM, Valdez LM, La Rosa M. Severe COVID-19 during pregnancy and possible vertical transmission. Am J Perinatol. 2020;37(08):861-865. Doi: 10.1055/s-0040-1710050 https://doi.org/10.1055/s-0040-1710050...
|
Peru; Lima; British American Hospital |
41 |
33 weeks |
2,970 g |
6/8 |
Cesarean |
Positive RT-PCR in the nasopharyngeal swab – newborn 16 hours after delivery. Repeated in 48 hours: also positive. |
5 days |
Not justified: RT-PCR in the nasopharyngeal swab collected 12 hours after delivery. |
#7Vivanti et al. 1414 Vivanti AJ, Vauloup-Fellous C, Prevot S, Zupan V, Suffee C, Do Cao J, Benachi A, et al. Transplacental transmission of SARS-CoV-2 infection. Nat Commun. 2020;11(01):3572. Doi: 10.1038/s41467-020-17436-6 https://doi.org/10.1038/s41467-020-17436...
|
France; Paris Saclay University Hospitals |
23 |
35 weeks 5 days |
2,540 g |
4/1 |
Cesarean |
Amniotic fluid collected during cesarean section positive on RT-PCR (Genes E and S).Nasopharyngeal and rectal swabs collected within 1 hour, 3 days and 18 days of life were positive on RT-PCR (Genes E and S).Blood and non-bronchoscopic bronchoalveolar lavage fluid collected before extubation (6 hours after delivery) positive on RT-PCR (Genes E and S). |
5 days |
Justified: positive RT-PCR in the amniotic fluid and in the neonate blood sample collected before 12 hours of delivery. |
#8Mehta et al. 1515 Mehta H, Ivanovic S, Cronin A, VanBrunt L, Mistry N, Miller R, Yodice P, et al. Novel coronavirus-related acute respiratory distress syndrome in a patient with twin pregnancy: A case report. Case Rep Womens Health. 2020;27:e00220. Doi: 10.1016/j.crwh.2020.e00220 https://doi.org/10.1016/j.crwh.2020.e002...
|
United States; Liningston; Saint Barnabas Medical Center |
39 |
27 weeks |
Baby A: 925 g;Baby B: 1,050 g |
Baby A: 1/3;Baby B: 5/6 |
Cesarean |
Twin A tested positive and twin B tested negative for SARS-CoV-2 at 72 hours, and it is not clear what type of test was performed. The authors believe that twin A tested positive due to vertical transmission. |
14 days |
Not justified: the type of test performed is not described properly, and it was performed 12 hours after delivery. |
#9Sun et al. 1616 Sun M, Xu G, Yang Y, Tao Y, Pian-Smith M, Madhavan V, et al. Evidence of mother-to-newborn infection with COVID-19. Br J Anaesth. 2020;125(02):e245-e247. Doi: 10.1016/j.bja.2020.04.066 https://doi.org/10.1016/j.bja.2020.04.06...
|
China; Henan; Henan Provincial People's Hospital |
28 |
37 weeks |
Not informed |
9/9 |
Cesarean |
Obstetricians, anesthesiologists, neonatologists, and nurses wore full personal protective equipment, including an N95 mask, eye goggles, face shield, and a top-to-bottom tight-fitting gown, entering the operating theaters ∼ 5 minutes before the patients. Neonate tested positive for SARS-CoV-2 at day 6 postpartum. |
9 days of maternal symptoms + 6 postnatal days |
Not justified: RT-PCR in the oropharynx swab collected 12 hours after delivery. |