INTERMITTENT HIGH INTENSITY EXERCISE ASSOCIATED WITH DRUGS IN PATIENTS WITH TYPE 2 DIABETES

ABSTRACT Introduction: Some studies point out that high-intensity intermittent training exercises combined with drugs may improve the endurance of patients with type 2 diabetes. However, the information concerning blood glucose control still needs to be better evidenced. Objective: Explore further the effect of intermittent high-intensity exercise combined with drugs on blood glucose control in patients with type 2 diabetes. Methods: Through a control experiment, 100 patients were selected from volunteers, and divided equally into two groups for this experiment. A protocol with high-intensity intermittent exercise for intervention associated with drug treatment was added to the experimental group, while the control received standard drug treatment. Results: The results of each index in the experimental group were: TC pre 4.80±1.00, post 4.56±0.78; TG pre 1.77±1.15, post 1.49±1.16; LDL pre 2.94±0.83, post 2.51±0.73. The experimental results proved that all indices in the experimental group were improved, but the changes in the control group were not evidenced. Conclusion: Intermittent high-intensity exercise combined with drugs positively affected blood glucose control in patients with type 2 diabetes. Level of evidence II; Therapeutic studies - investigation of treatment outcomes.


INTRODUCTION
For patients who have just been diagnosed with type 2 diabetes, most clinicians advocate intensive treatment by using short-term insulin, which can effectively control the blood sugar level of patients in a short time, and also can well avoid toxic events caused by high blood sugar.In the past clinical cases, most patients were treated with conventional insulin, but this did not achieve the desired goal.With the deepening of research, people gradually found that as a chronic disease, type 2 diabetes not only needs effective drug treatment, but also needs appropriate exercise and nursing intervention.However, many patients are busy with their own work, and it is difficult to devote a lot of time to exercise, which will lead to insufficient exercise and poor exercise effect. 1 Therefore, under the condition of shortening the patient's exercise time as much as possible, how to achieve effective exercise intervention and nursing intervention effect is the focus of the study. 2High intensity interval training has become the research direction chosen by the author.The benefits of high intensity interval training in physical health have been confirmed by a large number of scientific research. 3,4High-intensity interval training is a training mode that uses a short time to carry out high-intensity training and adds a short interval time during the exercise. 5Compared with the original medium-intensity continuous training mode, it can be found that high-intensity interval training has similar or even better improvement effects in physiological adaptation, functional development, health improvement and performance improvement after exercise.However, high-intensity interval training also has corresponding disadvantages. 6High-intensity interval training has very strict requirements for training methods. 7This kind of sports training mode is dangerous for some groups.Therefore, when carrying out high-intensity intermittent exercise training for patients with type 2 diabetes, professional doctors and sports experts should consult with each other according to the patient's condition and physical condition, discuss a suitable exercise program for the patient, and nurses should carry out effective nursing intervention.Therefore, this article explores the effect of high-intensity intermittent exercise combined with drugs and effective nursing intervention on blood glucose control in patients with type 2 diabetes.

METHOD Research object
In order to further explore the effect of high-intensity intermittent exercise intervention and nursing intervention on the blood sugar control effect of type 2 diabetes patients at the same time of drug intervention treatment, this paper selects 100 type-2 diabetes patients as the experimental objects, and randomly divides the 100 type-2 diabetes patients into two groups, namely, the experimental group and the control group.The study and all the participants were reviewed and approved by Ethics Committee of Guangzhou Medical University (GZMU21TP039).

Research methods
The patients in the experimental group and the control group were randomly assigned to carry out a four-week experiment.Among them, the patients in the experimental group received an hour of high-intensity intermittent exercise training every day.The training of this hour was divided into a time unit of every 20 minutes, and 15 minutes of training and 5 minutes of rest were carried out within the 20 minutes.At the same time, the patients in the experimental group also received drug intervention treatment as usual and effective nursing intervention.The control group was only treated with simple drug intervention.In the process of training, the experimental data of each index of the experimental object shall be recorded in time, and the professional software shall be used for recording and sorting, for the analysis of the follow-up results.

Current status of blood glucose control of subjects
Figure 1 shows the data results of the blood glucose control status of 100 subjects before the start of the control experiment.It can be seen from Figure 1 that at each time point of blood glucose measurement, the number of people who met the standard on an empty stomach was 24, and the number of people who did not meet the standard was 76; The number of people who meet the standard 2 hours after breakfast is 15, and the number of people who fail to meet the standard is 85; The number of people who met the standard 2 hours after lunch was 18, and the number of people who did not meet the standard was 82.It can be seen that the blood sugar control of most patients was not up to the standard.

High intensity intermittent exercise combined with drug intervention to improve the physique of patients with type 2 diabetes
Table 1 shows the experimental data of type 2 diabetes patients' physical fitness improved after 1 hour of high-intensity intermittent exercise training with nursing intervention every day while they were given routine drug treatment for 4 weeks.
Further study and analyze the change of P value of each index in the data in Table 1.The P value of muscle mass index is 0.0131, the P value of skeletal muscle content is 0.0075, the P value of grip strength is 0.0261, the P value of six meters is 0.0076, and the P value of sitting up for 30 seconds is 0.0183.The P value of all indicators is less than 0.05, which indicates that there is a significant difference between the two groups of data before and after the experiment, which proves that the patients' physique has been greatly improved by high intensity intermittent exercise training and drug intervention, especially in the aspects of skeletal muscle content index and six-meter duration.
Table 2 shows the experimental data obtained after the patients with type 2 diabetes only received simple drug intervention treatment for 4 weeks.
In Table 2, the P value of muscle mass index is 0.0364, the P value of skeletal muscle content is 0.0318, the P value of grip strength is 0.0384, the P value of six-meter use is 0.0365, and the P value of sitting up for 30s is 0.0339.It can be seen that the P value of all index data is less than 0.05, indicating that there are significant differences between the data of each index before and after the experiment.It is proved that simple drug intervention can improve the physique of patients with type 2 diabetes.However, after one-to-one comparison of the P values of the data indicators in Table 1 and Table 2, it is found that the experimental indicators in Table 1 are higher than those in Table 2, which proves that the physique of the patients undergoing high-intensity intermittent exercise training and drug intervention is more improved than that of the patients with drug intervention alone.

Effect of high-intensity intermittent exercise combined with drug intervention on blood glucose control in patients with type 2 diabetes
Table 3 shows the experimental data of the improvement of blood sugar control in type 2 diabetes patients after training with 1 hour of high-intensity intermittent exercise training and nursing intervention every day, while the patients with type 2 diabetes received routine drug treatment for 4 weeks In Table 3, the P value of TC index is 0.0056, the P value of TG index is 0.0182, the P value of HDL index is 0.0248, the P value of LDL index is 0.0239, the P value of HbA 1c index is 0.0295, and the P value of FBG index is 0.0144.The P value of all the experimental data indicators is less than 0.05, which proves that the high intensity intermittent exercise training combined with drug intervention treatment has improved the blood sugar control of patients.
Table 4 shows the experimental data indicators obtained after the blood glucose control of the constitution of type 2 diabetes patients who only received drug intervention for 4 weeks.Among them, the data of TC indicators before the experimental intervention was 4.364 ± 0.553, and the data after the experimental intervention was 4.572 ± 0.446; The data of TG index before experimental intervention was 2.182 ± 0.989, and the data after experimental intervention was 2.090 ± 1.054; The data of HDL index before and after intervention were 1.718 ± 0.357 and 1.418 ± 0.328 respectively; The data of LDL index before experimental intervention was 2.893 ± 0.495, and the data after experimental intervention was 2.964 ± 0.519; The data of HbA 1c index before the experiment intervention was 7.349 ± 1.233, and the data after the experiment intervention was 7.631 ± 1.237; The data of FBG index before experimental intervention was 8.693 ± 3.386, and the data after experimental intervention was 9.765 ± 2.779.
In Table 4, the P value of TC index is 0.0352, TG index is 0.0327, HDL index is 0.0396, LDL index is 0.0384, HbA 1c index is 0.0328, and FBG index is 0.0344.The P value of all indicators is less than 0.05, which proves that only drug intervention can also improve the blood sugar control of patients' physique.After a one-to-one comparison of the P values of the data indicators in Table 3 and Table 4, it was found that the experimental indicators in Table 3 were higher than those in Table 4, which proved that the effect of glycemic control of the constitution of the patients who received high-intensity intermittent exercise training with drug intervention was better than that of the patients who received drug intervention alone.
Figure 2 shows the status quo of blood glucose control of the subjects after the experiment, and the data results of the 100 subjects after the experiment in terms of the status quo of blood glucose control.It can be seen from Figure 2 that the number of people who met the standard on an empty stomach was 56, and the number of people who did not meet the standard was 44; The number of people who met the standard 2 hours after breakfast was 68, and the number of people who did not

Figure 2 .
Figure 2. Status quo of blood glucose control of subjects after the experiment.

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Table 1 .
High intensity intermittent exercise combined with drug nursing intervention to improve the physique of patients with type 2 diabetes.

Table 2 .
Effect of simple drug intervention on constitution of type 2 diabetes patients.

Table 3 .
Effect of high-intensity intermittent exercise combined with drug intervention on blood glucose control in patients with type 2 diabetes.

Table 4 .
Effect of simple drug intervention on blood glucose control of type 2 diabetes patients.