EFECTO DEL CONSUMO DE VITAMINA E SOBRE EL DAÑO MUSCULAR Y EL ESTRÉS OXIDATIVO: UNA REVISIÓN SISTEMÁTICA CON METAANÁLISIS DE ENSAYOS CONTROLADOS ALEATORIOS

Zhou, Yanling; Liang, Li

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Revista Brasileira de Medicina do Esporte

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Review article • Rev Bras Med Esporte 28 (5) • Sep-Oct 2022 • https://doi.org/10.1590/1517-8692202228052021_545 copiar

EFECTO DEL CONSUMO DE VITAMINA E SOBRE EL DAÑO MUSCULAR Y EL ESTRÉS OXIDATIVO: UNA REVISIÓN SISTEMÁTICA CON METAANÁLISIS DE ENSAYOS CONTROLADOS ALEATORIOS

Autoría SCIMAGO INSTITUTIONS RANKINGS

RESUMEN

Introducción:

La suplementación con vitamina E puede tener un efecto protector contra el daño muscular inducido por el ejercicio (EIMD) a través de la posible inhibición de la formación de radicales libres y la estabilización de la membrana celular. Sin embargo, no existe ninguna revisión sistemática sobre este tema. Este hecho mantiene un impasse académico que puede tener resolución.

Objetivo:

Esta revisión sistemática con meta-análisis tiene como objetivo proporcionar una amplia revisión de la literatura sobre la hipótesis del beneficio de la suplementación con vitamina E sobre el estrés oxidativo y el daño muscular inducido por el ejercicio aeróbico.

Métodos:

Se utilizó un modelo de efectos aleatorios, se aplicó la diferencia de medias ponderada (DMP) y el intervalo de confianza (IC) del 95% para estimar el efecto global.

Resultados:

Los resultados revelaron un efecto significativo de la suplementación con vitamina E en la reducción de la creatina quinasa (CK) y la lactato deshidrogenasa (LDH). Además, un análisis de subgrupos dio como resultado una disminución significativa de las concentraciones de CK en los ensayos con medición de CK inmediata y <24 horas después del ejercicio; <1000 en la ingesta diaria de vitamina E; ≤1 en la ingesta semanal; 1 en 6 semanas y >6 semanas de duración experimental, los estudios sobre el ejercicio aeróbico y el entrenamiento formaron parte del estudio cruzado.

Conclusión:

La vitamina E puede resultar un agente prioritario para la recuperación del daño muscular. Nivel de evidencia II; Estudios terapéuticos - Investigación de resultados.

Descriptores:
Vitamina E; Creatina Quinasa; Lactato Deshidrogenasa; Malondialdehído; Metaanálisis

Author (year)	Study Design Characteristics						Average age (y)	Sample Size		Exercise type	Muscle damage indices	Oxidative stress indices
Author (year)	design	country	training status	vitamin E dose (IU/d)	duration (D)	gender	Average age (y)	vitamin E	control		Muscle damage indices	Oxidative stress indices
Kashef et al. (2018) ^* * Not randomized; ^# # Excluded from meta-analysis; ¹⁷17 Kashef M. Effect of vitamin E supplementation on delayed onset muscle soreness in young men. Journal of Physical Activity and Hormones. 2018;2(3):15-28.	RP	Iran	U	400	30	M	22.8	10	10	resistance	CK	MDA
Bataineh et al. (2017) ¹³13 Bataineh MF, Al-Nawaiseh AM, Taifour A, Judge LW. Dead Sea Marathon-Induced Muscle Damage and Acute Oral Vitamin E Supplementation. Journal of Exercise Physiology Online. 2017;20(3):1-13.	RP	Jordan	T	400	5	M	31	7	7	aerobic	CK
Santos et al. (2016) ¹⁸18 Santos S, Silva ET, Caris AV, Lira FS, Tufik S, Dos Santos RVT. Vitamin E supplementation inhibits muscle damage and inflammation after moderate exercise in hypoxia. Journal of Human Nutrition and Dietetics. 2016;29(4):516-22.	CP	Brazil	^{^} ^ Unknown; ^† † Coded in the meta-analysis as untrained.	550	1	M	24.2	9	9	aerobic	CK, LDH
Taghiyar et al. (2013) ²²22 Taghiyar M, Darvishi L, Askari G, et al. The effect of vitamin C and e supplementation on muscle damage and oxidative stress in female athletes: a clinical trial. International journal of preventive medicine. 2013;4(Suppl 1):S16.	RP	Iran	T	400	28	F	22.5	10	10	aerobic	CK, LDH	MDA
Silva et al. (2010) ²⁷27 Silva LA, Pinho CA, Silveira PCL, Tuon T, De Souza CT, Dal-Pizzol F et al. Vitamin E supplementation decreases muscular and oxidative damage but not inflammatory response induced by eccentric contraction. The journal of physiological sciences. 2010;60(1):51-7.	RP	Brazil	U	800	21	M	22.5	11	10	resistance	LDH
Keong et al. (2006) ¹⁴14 Keong CC, Singh HJ, Singh R. Effects of palm vitamin E supplementation on exercise-induced oxidative stress and endurance performance in the heat. Journal of sports science & medicine. 2006;5(4):629-39.	CP	Malaysia	T	130	42	M	24.9	18	18	aerobic	CK	MDA
Gaeini et al. (2006) ^¥ ¥ No data access. ^# # Excluded from meta-analysis; ¹²12 Gaeini AA, Rahnama N, Hamedinia MR. Effects of vitamin E supplementation on oxidative stress at rest and after exercise to exhaustion in athletic students. Journal of sports medicine and physical fitness. 2006;46(3):458-61.	RP	Iran	T	1000	56	M	20.3	^{^} ^ Unknown;	^{^} ^ Unknown;	aerobic	CK	MDA
Sacheck et al. (2003) ²¹21 Sacheck JM, Milbury PE, Cannon JG, Roubenoff R, Blumberg B. Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men. Free radical biology and medicine. 2003;34(12):1575-88.	RP	USA	U	1000	84	M	26.4	8	8	aerobic	CK	MDA
Sacheck et al. (2003) ²¹21 Sacheck JM, Milbury PE, Cannon JG, Roubenoff R, Blumberg B. Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men. Free radical biology and medicine. 2003;34(12):1575-88.	RP	USA	U	1000	84	M	71.4	8	8	aerobic	CK	MDA
Avery et al. (2003) ²⁵25 Avery NG, Kaiser JL, Sharman MJ, Scheett TP, Barnes DM, Gómez AL et al. Effects of vitamin E supplementation on recovery from repeated bouts of resistance exercise. The Journal of Strength & Conditioning Research. 2003;17(4):801-9.	RP	USA	T	1200	21	M	22.5	9	9	resistance	CK	MDA
Beaton et al. (2002) ¹⁵15 Beaton LJ, Allan DA, Tarnopolsky MA, Tiidus PM, Phillips SM. Contraction-induced muscle damage is unaffected by vitamin E supplementation. Medicine & Science in Sports & Exercise. 2002;34(5):798-805.	RP	Canada	U	1200	30	M	20.3	9	7	resistance	CK
Niess et al. (2001) ²³23 Niess AM, Fehrenbach E, Schlotz E, Sommer M, Angres C, Tschositsch K et al. Effects of RRR-α-tocopherol on leukocyte expression of HSP72 in response to exhaustive treadmill exercise. International journal of sports medicine. 2002;23(06):445-52.	CP	Germany	T	500	8	M	25.3	9	9	aerobic	CK
Buchman et al. (1999) ¹⁶16 Buchman AL, Killip D, Ou CN, Rognerud CL, Pownall H, Dennis K et al. Short-term vitamin E supplementation before marathon running: a placebo-controlled trial. Nutrition. 1999;15(4):278-83.	RP	USA	U	1000	14	M & F	18–55	5	14	aerobic	CK
Itoh et al. (1999) ²⁶26 Itoh H, Ohkuwa T, Yamazaki Y, Shimoda T, Wakayama A, Tamura S et al. Vitamin E supplementation attenuates leakage of enzymes following 6 successive days of running training. International Journal of Sports Medicine. 2000;21(05):369-74	RP	Japan	U	1200	28	M	21.4	7	7	aerobic	CK, LDH
Cannon et al. (1990) ¹¹11 Cannon JG, Orencole SF, Fielding RA, Meydani M, Meydani SN, Fiatarone MA et al. Acute phase response in exercise: interaction of age and vitamin E on neutrophils and muscle enzyme release. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 1990;259(6):R1214-9.	RP	USA	U	800	48	M	<30	4	5	aerobic	CK	MDA
Cannon et al. (1990) ¹¹11 Cannon JG, Orencole SF, Fielding RA, Meydani M, Meydani SN, Fiatarone MA et al. Acute phase response in exercise: interaction of age and vitamin E on neutrophils and muscle enzyme release. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 1990;259(6):R1214-9.	RP	USA	U	800	48	M	>55	6	6	aerobic	CK	MDA
McBride et al. (1990) ²⁴24 McBride JM, Kraemer WJ, Triplett-McBride T, Sebastianelli W. Effect of resistance exercise on free radical production. Medicine & Science in Sports & Exercise. 1998;30(1):67-72.	RP	USA	T	1200	14	M	21	6	6	resistance	CK	MDA

Study	Random Sequence Generation	Allocation concealment	Blinding of participants and personnel	Blinding of outcome assessment	Incomplete outcome data	Selective outcome reporting	Other sources of bias	Overall Risk of Bias
Bataineh et al. (2017)¹³13 Bataineh MF, Al-Nawaiseh AM, Taifour A, Judge LW. Dead Sea Marathon-Induced Muscle Damage and Acute Oral Vitamin E Supplementation. Journal of Exercise Physiology Online. 2017;20(3):1-13.	U	L	H	H	L	H	U	High
Santos et al. (2016)¹⁸18 Santos S, Silva ET, Caris AV, Lira FS, Tufik S, Dos Santos RVT. Vitamin E supplementation inhibits muscle damage and inflammation after moderate exercise in hypoxia. Journal of Human Nutrition and Dietetics. 2016;29(4):516-22.	U	L	L	U	L	L	L	Medium
Taghiyar et al. (2013)²²22 Taghiyar M, Darvishi L, Askari G, et al. The effect of vitamin C and e supplementation on muscle damage and oxidative stress in female athletes: a clinical trial. International journal of preventive medicine. 2013;4(Suppl 1):S16.	L	L	L	U	L	L	L	Medium
Silva et al. (2010)²⁷27 Silva LA, Pinho CA, Silveira PCL, Tuon T, De Souza CT, Dal-Pizzol F et al. Vitamin E supplementation decreases muscular and oxidative damage but not inflammatory response induced by eccentric contraction. The journal of physiological sciences. 2010;60(1):51-7.	L	U	L	U	L	L	L	Medium
Keong et al. (2006)¹⁴14 Keong CC, Singh HJ, Singh R. Effects of palm vitamin E supplementation on exercise-induced oxidative stress and endurance performance in the heat. Journal of sports science & medicine. 2006;5(4):629-39.	U	L	L	U	L	L	L	Medium
Sacheck et al. (2003)²¹21 Sacheck JM, Milbury PE, Cannon JG, Roubenoff R, Blumberg B. Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men. Free radical biology and medicine. 2003;34(12):1575-88.	U	L	L	U	L	L	L	Medium
Avery et al. (2003)²⁵25 Avery NG, Kaiser JL, Sharman MJ, Scheett TP, Barnes DM, Gómez AL et al. Effects of vitamin E supplementation on recovery from repeated bouts of resistance exercise. The Journal of Strength & Conditioning Research. 2003;17(4):801-9.	U	U	L	U	L	L	U	Medium
Beaton et al. (2002)¹⁵15 Beaton LJ, Allan DA, Tarnopolsky MA, Tiidus PM, Phillips SM. Contraction-induced muscle damage is unaffected by vitamin E supplementation. Medicine & Science in Sports & Exercise. 2002;34(5):798-805.	U	U	L	L	L	L	L	Medium
Niess et al. (2001)²³23 Niess AM, Fehrenbach E, Schlotz E, Sommer M, Angres C, Tschositsch K et al. Effects of RRR-α-tocopherol on leukocyte expression of HSP72 in response to exhaustive treadmill exercise. International journal of sports medicine. 2002;23(06):445-52.	U	L	L	U	L	H	L	Medium
Buchman et al. (1999)¹⁶16 Buchman AL, Killip D, Ou CN, Rognerud CL, Pownall H, Dennis K et al. Short-term vitamin E supplementation before marathon running: a placebo-controlled trial. Nutrition. 1999;15(4):278-83.	U	U	L	U	L	L	U	Medium
Itoh et al. (1999)²⁶26 Itoh H, Ohkuwa T, Yamazaki Y, Shimoda T, Wakayama A, Tamura S et al. Vitamin E supplementation attenuates leakage of enzymes following 6 successive days of running training. International Journal of Sports Medicine. 2000;21(05):369-74	U	U	U	H	L	L	L	Medium
Cannon et al. (1990)¹¹11 Cannon JG, Orencole SF, Fielding RA, Meydani M, Meydani SN, Fiatarone MA et al. Acute phase response in exercise: interaction of age and vitamin E on neutrophils and muscle enzyme release. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 1990;259(6):R1214-9.	L	U	U	U	L	L	L	Medium
McBride et al. (1990)²⁴24 McBride JM, Kraemer WJ, Triplett-McBride T, Sebastianelli W. Effect of resistance exercise on free radical production. Medicine & Science in Sports & Exercise. 1998;30(1):67-72.	U	L	H	H	L	H	U	High

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[1] Correspondence: Yanling Zhou Guangxi, China, 541004. zyl170728@163.com