PURPOSE: Evaluation of the effects of topic ibopamine in normal eyes, suspects and eyes with primary open-angle glaucoma (POAG) as well as your efficacy as a provocative test for glaucoma. METHODS: 10 POAG pacients (20 eyes), 10 pacients suspects of POAG (20 eyes) and 10 normal Pacients (20 eyes) were selected and submitted to the topic ibopamine test. The test was considered positive when in one of the measures (30, 45 and 60 minutes) after instillation of 2 drops of 2% ibopamine, 5 minutes apart, the intraocular pressure (IOP) elevation was = 4 mmHg. RESULTS: The ibopamine test was positive in 16 (88%) eyes with POAG, 9 (45%) eyes suspects of POAG and 6 (30%) normal eyes. The best sensitivity/specificity ratio was achieved at 60 minutes for both eyes (Se/Sp: 90%) . All patients described a slight burning after ibopamine's instillation. CONCLUSION: The results of this study suggests that topical 2% ibopamine is a secure alternative to evaluate outflow system impairment in eyes with glaucoma.
Dopamine agonists; Dopamine agonists; Open-angle glaucoma; Intraocular pressure; Ophthalmic solutions; Sensitivity and specificity
