An index to examine the sexual HIV risk of psychiatric service users based on sexual partners

Andrea Norcini Pala Karen McKinnon Melanie M. Wall Francine Cournos Mark D. Guimaraes Milton L. Wainberg About the authors

Numerous studies report higher HIV infection rates among psychiatric patients than in the general population.11. Hughes E, Bassi S, Gilbody S, Bland M, Martin F. Prevalence of HIV, hepatitis B, and hepatitis C in people with severe mental illness: a systematic review and meta-analysis. Lancet Psychiatry. 2016;3:40-8. Relative to other HIV-affected populations, they have higher rates of HIV-related risk behaviors in fewer sexual occasions, including multiple partners, partners of unknown or positive HIV status, sex in exchange for money, shelter or goods, and low condom use rates.22. Campos LN, Guimarães MD, Carmo RA, Melo AP, Oliveira HN, Elkington K, et al. HIV, syphilis, and hepatitis B and C prevalence among patients with mental illness: a review of the literature. Cad Saude Publica. 2008;24:s607-20. We present a new HIV risk index (RI)33. Guimarães MDC, Rocha GM, Kerr LRFS, Brito AM, Dourado I. Risk behavior score for HIV based on unprotected anal sex and multiple sexual partnerships among men who have sex with men (MSM) in Brazil. In: 20th International AIDS Conference; 2014 July 20-25; Melbourne, Australia. Poster Exhibition # THPE149. that takes into account differential risk associated with these factors.

Anal/vaginal receptive sex is riskier than insertive practices. Sex acts with partners of unknown/positive HIV status are riskier than those with HIV-negative partners, regardless of partner type.44. Peterman TA, Lin LS, Newman DR, Kamb ML, Bolan Gail, Zenilman J, et al. Does measured behavior reflect STD risk? An analysis of data from a randomized controlled behavioral intervention study. Project Respect Study Group. Sex Transm Dis. 2000;27:446-51. Lastly, sex acts with steady, casual, and exchange partners are associated with different HIV risk.55. Varghese B, Maher JE, Peterman TA, Branson BM, Steketee RW. Reducing the risk of sexual HIV transmission: quantifying the per-act risk for HIV on the basis of choice of partner, sex act, and condom use. Sex Transm Dis. 2002;29:38-43.

Our RI assigns differential risk to each sex act and sums risk across sex acts. The differential risk consists of three risk coefficients: 1) partner (type and HIV status); 2) vaginal sex (insertive or receptive) per sex occasion; and 3) anal sex (insertive or receptive) per sex occasion. Risk coefficients for vaginal/anal directionality are based on CDC transmission risk values,66. Centers for Disease Control and Prevention. HIV risk behaviors [Internet]. [cited 2017 Apr 06]. cdc.gov/hiv/risk/estimates/riskbehaviors.html
cdc.gov/hiv/risk/estimates/riskbehaviors...
while coefficients proposed for partner type were determined on the basis of expert opinion and face validity (Table 1).

Table 1
Risk coefficients by sex partner type and HIV status, sex occasions

RI is estimated for each sex partner (RIn); the sum of all RIn corresponds to the total RI score. We provide three examples to demonstrate the new RI in comparison to focusing only on condomless sex proportions.

Example 1. A man had four anal sex acts, one insertive and three receptive, all condomless, with a casual male HIV-unknown partner. Taking into account the three risk coefficients, this person would have an RI = 0.90*(0.11*1+1.38*3) = 3.83. Based solely on the proportion of condomless sex occasions, this person’s risk would be classified as 100%.

Example 2. A man had three vaginally insertive acts, all condomless, with a casual HIV-negative partner. This person would have an RI = 0.10*(0.04*3) = 0.01. His risk classification based on the proportion of condomless sex occasions is 100%, which would not distinguish him meaningfully from the man in Example 1.

Example 3. A woman had sex with two male partners, steady HIV-negative and exchange HIV-unknown. The one sex occasion with the steady partner was condomless; with the exchange partner, she had seven sex occasions, of which one was condomless vaginal and three were condomless anal (total sex occasions = 8; condomless sex occasions = 5). Thus, RI1 (Partner 1) = 0.01*(0.08*1) = 0.001; RI2 (Partner 2) = 0.90*(0.01*1+1.38*3) = 3.74; RITotal = 0.001+3.74 = 3.74. The proportion of condomless sex occasions would be 62.5%. Relative to Example 1, the RI shows this person’s risk approximating his, though the proportion of condomless occasions shows her to be at considerably less risk.

Using our RI, possible misclassifications of risk based solely on the proportion of condomless sex occasions were identified. RI offers greater precision in estimating risk within psychiatric and potentially other populations now that Brazil is considering pre-exposure prophylaxis (PrEP – PrEPBrasil.com.br) for those at high risk. Additional behavioral and infection rate data are needed to further differentiate and validate high risk.

Acknowledgements

ANP is supported by a NIMH training grant (T32-MH19139 Behavioral Sciences Research in HIV Infection; Principal Investigator: Theodorus Sandfort).

References

  • 1
    Hughes E, Bassi S, Gilbody S, Bland M, Martin F. Prevalence of HIV, hepatitis B, and hepatitis C in people with severe mental illness: a systematic review and meta-analysis. Lancet Psychiatry. 2016;3:40-8.
  • 2
    Campos LN, Guimarães MD, Carmo RA, Melo AP, Oliveira HN, Elkington K, et al. HIV, syphilis, and hepatitis B and C prevalence among patients with mental illness: a review of the literature. Cad Saude Publica. 2008;24:s607-20.
  • 3
    Guimarães MDC, Rocha GM, Kerr LRFS, Brito AM, Dourado I. Risk behavior score for HIV based on unprotected anal sex and multiple sexual partnerships among men who have sex with men (MSM) in Brazil. In: 20th International AIDS Conference; 2014 July 20-25; Melbourne, Australia. Poster Exhibition # THPE149.
  • 4
    Peterman TA, Lin LS, Newman DR, Kamb ML, Bolan Gail, Zenilman J, et al. Does measured behavior reflect STD risk? An analysis of data from a randomized controlled behavioral intervention study. Project Respect Study Group. Sex Transm Dis. 2000;27:446-51.
  • 5
    Varghese B, Maher JE, Peterman TA, Branson BM, Steketee RW. Reducing the risk of sexual HIV transmission: quantifying the per-act risk for HIV on the basis of choice of partner, sex act, and condom use. Sex Transm Dis. 2002;29:38-43.
  • 6
    Centers for Disease Control and Prevention. HIV risk behaviors [Internet]. [cited 2017 Apr 06]. cdc.gov/hiv/risk/estimates/riskbehaviors.html
    » cdc.gov/hiv/risk/estimates/riskbehaviors.html

Publication Dates

  • Publication in this collection
    June 2017

History

  • Received
    8 Aug 2016
  • Accepted
    15 Dec 2016
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