Aust et al.3232. Aust S, Brakemeier EL, Spies J, Herrera-Melendez AL, Kaiser T, Fallgatter A, et al. Efficacy of augmentation of cognitive behavioral therapy with transcranial direct current stimulation for depression: a randomized clinical trial. JAMA Psychiatry. 2022;79:528-37. |
95 |
53.0 |
40.9 (13.8) |
2 |
0 |
2.0 |
35.0 |
0.57 |
12 |
F3 |
F4 |
30 |
1 |
Bennabi et al.3333. Bennabi D, Nicolier M, Monnin J, Tio G, Pazart L, Vandel P, et al. Pilot study of feasibility of the effect of treatment with tDCS in patients suffering from treatment-resistant depression treated with escitalopram. Clin Neurophysiol. 2015;126:1185-9. |
48 |
64.4 |
60.2 (13.7) |
2 |
1 |
2.0 |
35.0 |
0.57 |
10 |
F3 |
Fp2 |
30 |
2 |
Blumberger et al.3434. Blumberger DM, Tran LC, Fitzgerald PB, Hoy KE, Daskalakis ZJ. A randomized double-blind sham-controlled study of transcranial direct current stimulation for treatment-resistant major depression. Front Psychiatry. 2012;3:74. |
25 |
83.3 |
47.5 (10.5) |
1 |
1 |
2.0 |
35.0 |
0.57 |
15 |
F3 |
F4 |
20 |
1 |
Boggio et al.3535. Boggio PS, Rigonatti SP, Ribeiro RB, Myczkowski ML, Nitsche MA, Pascual-Leone A, et al. A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression. Int J Neuropsychopharmacol. 2008;11:249-54. |
32 |
64.5 |
49.1 (7.4) |
0 |
NR |
2.0 |
35.0 |
0.57 |
10 |
F3 |
Fp2 |
20 |
2 |
Brunoni et al.3636. Brunoni AR, Valiengo L, Baccaro A, Zanão TA, de Oliveira JF, Goulart A, et al. The sertraline vs. electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial. JAMA Psychiatry. 2013;70:383-91. ( - Sertraline) |
60 |
68.5 |
43.7 (13.0) |
0 |
1 |
2.0 |
25.0 |
0.80 |
12 |
F3 |
F4 |
30 |
3 |
Brunoni et al.3636. Brunoni AR, Valiengo L, Baccaro A, Zanão TA, de Oliveira JF, Goulart A, et al. The sertraline vs. electrical current therapy for treating depression clinical study: results from a factorial, randomized, controlled trial. JAMA Psychiatry. 2013;70:383-91. (+ Sertraline) |
60 |
68.0 |
41.0 (12.5) |
2 |
1 |
2.0 |
25.0 |
0.80 |
12 |
F3 |
F4 |
30 |
3 |
Brunoni et al.3737. Brunoni AR, Boggio PS, De Raedt R, Benseñor IM, Lotufo PA, Namur V, et al. Cognitive control therapy and transcranial direct current stimulation for depression: a randomized, double-blinded, controlled trial. J Affect Disord. 2014;162:43-9. |
37 |
29.0 |
43.8 (10.5) |
2 |
1 |
2.0 |
25.0 |
0.80 |
10 |
F3 |
F4 |
30 |
3 |
Brunoni et al.1414. Brunoni AR, Moffa AH, Sampaio-Junior B, Borrione L, Moreno ML, Fernandes RA, et al. Trial of electrical direct-current therapy versus escitalopram for depression. N Engl J Med. 2017;376:2523-33. |
154 |
68.0 |
42.8 (12.3) |
0 |
1 |
2.0 |
25.0 |
0.80 |
22 |
F5 |
F6 |
30 |
4 |
Fregni et al.1313. Fregni F, Boggio PS, Nitsche MA, Marcolin MA, Rigonatti SP, Pascual-Leone A. Treatment of major depression with transcranial direct current stimulation. Bipolar Disord. 2006;8:203-4. |
19 |
61.0 |
46.6 (9.8) |
0 |
NR |
1.0 |
35.0 |
0.28 |
5 |
F3 |
Fp2 |
20 |
5 |
Loo et al.3838. Loo CK, Sachdev P, Martin D, Pigot M, Alonzo A, Malhi GS, et al. A double-blind, sham-controlled trial of transcranial direct current stimulation for the treatment of depression. Int J Neuropsychopharmacol. 2010;13:61-9. |
40 |
55.0 |
47.3 (11.2) |
1 |
0 |
1.0 |
35.0 |
0.29 |
5 |
Fp3 |
F8 |
20 |
6 |
Loo et al.3939. Loo CK, Alonzo A, Martin D, Mitchell PB, Galvez V, Sachdev P. Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial. Br J Psychiatry. 2012;200:52-9. |
64 |
47.0 |
48.2 (12.5) |
1 |
1 |
2.0 |
35.0 |
0.57 |
15 |
Fp3 |
F8 |
20 |
7 |
Loo et al.1515. Loo CK, Husain MM, McDonald WM, Aaronson S, O’Reardon JP, Alonzo A, et al. International randomized-controlled trial of transcranial direct current stimulation in depression. Brain Stimul. 2018;11:125-33. (Unipolar) |
84 |
50.0 |
48.1 (14.9) |
1 |
1 |
2.5 |
35.0 |
0.71 |
20 |
F3 |
F8 |
30 |
8 |
Mayur et al.4040. Mayur P, Howari R, Byth K, Vannitamby R. Concomitant transcranial direct current stimulation with ultrabrief electroconvulsive therapy: a 2-week double-blind randomized sham-controlled trial. J ECT. 2018;34:291-5. |
16 |
37.5 |
45.0 (14.6) |
2 |
1 |
2.0 |
25.0 |
0.80 |
10 |
F3 |
F4 |
30 |
3 |
Moirand et al.4141. Moirand R, Imbert L, Haesebaert F, Chesnoy G, Bediou B, Poulet E, et al. Ten sessions of 30 min tDCS over 5 days to achieve remission in depression: a randomized pilot study. J Clin Med Res. 2022;11:782. |
40 |
61.5 |
49.8 (9.5) |
1 |
1 |
2.0 |
35.0 |
0.57 |
10 |
F3 |
F4 |
30 |
1 |
Nord et al.4848. Nord CL, Halahakoon DC, Limbachya T, Charpentier C, Lally N, Walsh V, et al. Neural predictors of treatment response to brain stimulation and psychological therapy in depression: a double-blind randomized controlled trial. Neuropsychopharmacology. 2019;44:1613-22. |
39 |
51.3 |
33.3 (10.5) |
2 |
1 |
1.0 |
35.0 |
0.28 |
8 |
F3 |
Deltoid |
20 |
9 |
Pavlova et al.4242. Pavlova EL, Menshikova AA, Semenov RV, Bocharnikova EN, Gotovtseva GN, Druzhkova TA, et al. Transcranial direct current stimulation of 20- and 30-minutes combined with sertraline for the treatment of depression. Prog Neuropsychopharmacol Biol Psychiatry. 2018;82:31-8. |
69 |
72.0 |
38.3 (11.0) |
2 |
0 |
0.5 |
26.2 |
0.29 |
10 |
F3 |
Fp2 |
25 |
10 |
Salehinejad et al.4343. Salehinejad M, Rostami R, Ghanavati E. Transcranial direct current stimulation of dorsolateral prefrontal cortex of major depression: improving visual working memory, reducing depressive symptoms. NeuroRegulation. 2015;2:37-49. |
30 |
56.6 |
28.3 (N/I) |
0 |
NR |
2.0 |
35.0 |
0.57 |
10 |
F3 |
F4 |
20 |
1 |
Salehinejad et al.4444. Salehinejad MA, Ghanavai E, Rostami R, Nejati V. Cognitive control dysfunction in emotion dysregulation and psychopathology of major depression (MD): evidence from transcranial brain stimulation of the dorsolateral prefrontal cortex (DLPFC). J Affect Disord. 2017;210:241-8. |
24 |
62.5 |
26.2 (5.8) |
0 |
NR |
2.0 |
35.0 |
0.57 |
10 |
F3 |
F4 |
20 |
1 |
Segrave et al.4545. Segrave RA, Arnold S, Hoy K, Fitzgerald PB. Concurrent cognitive control training augments the antidepressant efficacy of tDCS: a pilot study. Brain Stimul. 2014;7:325-31. |
27 |
37.0 |
41.6 (12.9) |
2 |
NR |
2.0 |
35.0 |
0.57 |
5 |
F3 |
F8 |
24 |
1 |
Sharafi et al.4646. Sharafi E, Taghva A, Arbabi M, Dadarkhah A, Ghaderi J. Transcranial direct current stimulation for treatment-resistant major depression: a double-blind randomized sham-controlled trial. Clin EEG Neurosci. 2019;50:375-82. |
30 |
53.0 |
47.3 (11.6) |
0 |
1 |
2.0 |
20.0 |
1.00 |
10 |
F3 |
F4 |
20 |
11 |
Welch et al.4747. Welch ES, Weigand A, Hooker JE, Philip NS, Tyrka AR, Press DZ, et al. Feasibility of computerized cognitive-behavioral therapy combined with bifrontal transcranial direct current stimulation for treatment of major depression. Neuromodulation. 2019;22:898-903. |
14 |
85.7 |
54.8 (10.2) |
2 |
1 |
2.0 |
25.0 |
0.80 |
12 |
F3 |
F4 |
30 |
3 |