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Immature defense mechanisms predict poor response to psychotherapy in major depressive patients with comorbid cluster B personality disorder

Abstract

Objective:

To evaluate the impact of defense mechanisms at baseline on depressive symptoms after brief psychotherapies and after 6-months of follow-up among depressed patients with and without cluster B personality disorders (PDs).

Methods:

This quasi-experimental study nested within a randomized clinical trial included a clinical sample of adults (18-60 years) diagnosed with major depressive disorder using the Mini-International Neuropsychiatric Interview. The Millon Clinical Multiaxial Inventory-III was applied to assess PD, the Defense Style Questionnaire 40 was used to analyze defense mechanisms, and the Beck Depression Inventory was used to measure the severity of depressive symptoms. Adjusted analysis was performed by linear regression.

Results:

The final sample consisted of 177 patients diagnosed with major depressive disorder, of whom 39.5% had cluster B PDs. Immature defenses at baseline significantly predicted the persistence of depressive symptoms at post-intervention and at 6-months of follow-up only in patients with PDs.

Conclusion:

In depressed patients with cluster B PDs, immature defenses predicted a poor response to brief therapies. The assessment of immature defenses at baseline can help identify patients at greater risk of poor therapeutic results and enable more appropriate treatment choices.

Major depressive disorder; depressive symptoms; personality disorder; defense mechanisms


Introduction

Major depressive disorder (MDD), commonly known as depression, is among the main causes of incapacitation worldwide, affecting approximately 265 million people.11. World Health Organization (WHO). Depression – key facts [Internet]. 2020 [cited 2021 Aug 13]. www.who.int/news-room/fact-sheets/detail/depression
www.who.int/news-room/fact-sheets/detail...
A frequent comorbidity among depressed patients is personality disorder (PD), present in approximately 11 to 40% of this population according to some studies.22. Kavanagh BE, Williams LJ, Berk M, Turner A, Jackson HJ, Mohebbi M, et al. Personality disorder and functioning in major depressive disorder: a nested study within a randomized controlled trial. Braz J Psychiatry. 2020;42:14-21.

3. Unger T, Hoffmann S, Köhler S, Mackert A, Fydrich T. Personality disorders and outcome of inpatient treatment for depression: a 1-year prospective follow-up study. J Pers Disord. 2013;27:636-51.

4. Zimmerman M, Rothschild L, Chelminski I. The prevalence of DSM-IV personality disorders in psychiatric outpatients. Am J Psychiatry. 2005;162:1911-8.

5. Williams R, Farquharson L, Rhodes E, Dang M, Fitzpatrick N, Quirk A, et al. Impact of co-morbid personality disorder on quality of inpatient mental health services for people with anxiety and depression. Personal Ment Health. 2020;14:336-49.

6. Hasin DS, Goodwin RD, Stinson FS, Grant BF. Epidemiology of major depressive disorder: results from the national epidemiologic survey on alcoholism and related conditions. Arch Gen Psychiatry. 2005;62:1097-106.
-77. Moran P, Jenkins R, Tylee A, Blizard R, Mann A. The prevalence of personality disorder among UK primary care attenders. Acta Psychiatr Scand. 2000;102:52-7. PD is characterized as a maladaptive pattern of personality functioning, which causes suffering and significant losses for the individual.88. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR). Arlington: American Psychiatric Publishing; 2000. The high prevalence of this comorbidity is a major public health problem, since it affects treatment outcomes for depression by doubling the risk of poor therapeutic response99. Newton-Howes G, Tyrer P, Johnson T, Mulder R, Kool S, Dekker J, et al. Influence of personality on the outcome of treatment in depression: systematic review and meta-analysis. J Pers Disord. 2014;28:577-93. and suicide attempts and is associated with high mortality.1010. Cailhol L, Riedi G, Mathur A, Czapla P, Charpentier S, Genestal M, et al. [Should hospitalization be required after the emergency discharge of patients with borderline personality disorder who have attempted suicide (FRENCH CRISIS cohort)?]. Encephale. 2014;40:289-94.

11. Mazer AK, Macedo BBD, Juruena MF. Personality disorders. Medicina (Ribeirão Preto). 2017;50:85-97.
-1212. Mergui J, Raveh D, Gropp C, Golmard JL, Jaworowski S. Prevalence and characteristics of cluster B personality disorder in a consultation-liaison psychiatry practice. Int J Psychiatry Clin Pract. 2015;19:65-70.

PDs can be grouped into three clusters (A, B, and C), according to similar characteristics.1313. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Arlington: American Psychiatric Publishing; 2013. Cluster B, whose central characteristics include being more dramatic, emotional, or erratic, includes antisocial, histrionic, narcissistic, and borderline PDs.88. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR). Arlington: American Psychiatric Publishing; 2000. Previous studies have indicated that depressed patients with cluster B PDs respond differently to depression treatment, which highlights the need to assess this group of disorders separately.1414. Candrian M, Schwartz F, Farabaugh A, Perlis RH, Ehlert U, Fava M. Personality disorders and perceived stress in major depressive disorder. Psychiatry Res. 2008;160:184-91.,1515. Iacoviello BM, Alloy LB, Abramson LY, Whitehouse WG, Hogan ME. The role of cluster B and C personality disturbance in the course of depression: a prospective study. J Pers Disord. 2007;21:371-83. We chose to investigate patients with cluster B PDs because these disorders are associated with a poorer therapeutic response, including 71% lower remission of depressive symptoms after treatment.1616. George MP, Garrison GM, Merten Z, Heredia D Jr, Gonzales C, Angstman KB. Impact of personality disorder cluster on depression outcomes within collaborative care management model of care. J Prim Care Community Health. 2018;9:2150132718776877. In addition, the life expectancy of these patients is 20 years shorter than the general population,1717. Fok MLY, Hayes RD, Chang CK, Stewart R, Callard FJ, Moran P. Life expectancy at birth and all-cause mortality among people with personality disorder. J Psychosom Res. 2012;73:104-7.,1818. Sansone RA, Sansone LA. Responses of mental health clinicians to patients with borderline personality disorder. Innov Clin Neurosci. 2013;10:39-43. since cluster B PDs are associated with high rates of self-harm, suicide, and emergency hospitalizations,1212. Mergui J, Raveh D, Gropp C, Golmard JL, Jaworowski S. Prevalence and characteristics of cluster B personality disorder in a consultation-liaison psychiatry practice. Int J Psychiatry Clin Pract. 2015;19:65-70. leading to overuse of healthcare services66. Hasin DS, Goodwin RD, Stinson FS, Grant BF. Epidemiology of major depressive disorder: results from the national epidemiologic survey on alcoholism and related conditions. Arch Gen Psychiatry. 2005;62:1097-106. and greater difficulties in clinical management.1111. Mazer AK, Macedo BBD, Juruena MF. Personality disorders. Medicina (Ribeirão Preto). 2017;50:85-97.,1212. Mergui J, Raveh D, Gropp C, Golmard JL, Jaworowski S. Prevalence and characteristics of cluster B personality disorder in a consultation-liaison psychiatry practice. Int J Psychiatry Clin Pract. 2015;19:65-70.

One of the main components of the personality structure is the defense mechanism, which reveals psychodynamic aspects of the personality .1919. McWilliams N. Psychoanalytic diagnosis: understanding personality structure in the clinical process, 2nd ed. New York: Guilford Press; 2011. Defenses are unconscious mechanisms that protect the individual from excessive anxiety due to internal or external threats, preserving the maximum psychic balance.2020. Freud A. The ego and the mechanisms of defence. London: Karnac and the Institute of Psycho-Analysis; 1966. Defenses can be classified as mature, neurotic, or immature.2121. Vaillant GE. Theoretical hierarchy of adaptive ego mechanisms: a 30-year follow-up of 30 men selected for psychological health. Arch Gen Psychiatry. 1971;24:107-18. Mature defenses are defined by a greater ability to adapt to reality, allowing the individual to deal with threatening feelings without distorting reality.1919. McWilliams N. Psychoanalytic diagnosis: understanding personality structure in the clinical process, 2nd ed. New York: Guilford Press; 2011. Neurotic defenses involve an excess of anxiety and less control of the situation. Immature defenses suppress painful affections from consciousness through severe changes to the self and external reality.2222. Vaillant GE. Ego mechanisms of defense and personality psychopathology. J Abnorm Psychol. 1994;103:44-50.

Previous studies have reported that individuals who make greater use of immature defenses tend to exhibit more pathological personality traits,2323. Strandholm T, Kiviruusu O, Karlsson L, Miettunen J, Marttunen M. Defense mechanisms in adolescence as predictors of adult personality disorders. J Nerv Ment Dis. 2016;204:349-54. worsening depressive symptoms,2424. Babl A, Grosse Holtforth M, Perry JC, Schneider N, Dommann E, Heer S, et al. Comparison and change of defense mechanisms over the course of psychotherapy in patients with depression or anxiety disorder: evidence from a randomized controlled trial. J Affect Disord. 2019;252:212-20.,2525. Perry JC, Bond M. Change in defense mechanisms during long-term dynamic psychotherapy and five-year outcome. Am J Psychiatry. 2012;169:916-25. an increased risk of suicide attempts,2626. Corruble E, Bronnec M, Falissard B, Hardy P. Defense styles in depressed suicide attempters. Psychiatry Clin Neurosci. 2004;58:285-8. and impaired interpersonal relationships,2727. Silva BCM. Psicodinâmica e qualidade de vida do médico: um estudo transversal em Botucatu-SP [dissertation]. São Paulo: Universidade de São Paulo; 2013.,2828. Zeigler-Hill V, Pratt D. Defense styles and the interpersonal circumplex: the interpersonal nature of psychological defense. J Psychiatry. 2007;1:36-44. in addition to lower treatment adherence 2222. Vaillant GE. Ego mechanisms of defense and personality psychopathology. J Abnorm Psychol. 1994;103:44-50.,2929. Fitzpatrick T. Primitive defenses and unilateral termination of psychotherapy: are the lerner defense scales useful in predicting premature termination in psychotherapy? [dissertation]. Pittsburgh: Duquesne University; 2014. and poor therapeutic response.3030. Laaksonen MA, Sirkiä C, Knekt P, Lindfors O. Self-reported immature defense style as a predictor of outcome in short-term and long-term psychotherapy. Brain Behav. 2014;4:495-503. Although there is evidence that the coexistence of MDD with cluster B PDs is associated with a worse outcome in the treatment of depression, the effect of defense mechanisms underlying this worse therapeutic response remains poorly understood.1515. Iacoviello BM, Alloy LB, Abramson LY, Whitehouse WG, Hogan ME. The role of cluster B and C personality disturbance in the course of depression: a prospective study. J Pers Disord. 2007;21:371-83. A better understanding of the impact of defenses on the therapeutic response of individuals with cluster B PDs may facilitate baseline assessment and contribute to more adequate clinical management. Therefore, the objective of this study was to evaluate, in depressed patients with and without cluster B PDs, the impact of baseline defense mechanisms on depressive symptoms at the end of brief psychotherapies and after 6 months of follow-up.

Methods

Study design and participants

This quasi-experimental study nested within a randomized clinical trial included adults (aged 18-60 years) diagnosed with MDD according to the Mini-International Neuropsychiatric Interview Plus, a structured clinical interview for the DSM-IV.1313. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Arlington: American Psychiatric Publishing; 2013. From July 2012 to June 2015, the participants were recruited through advertisements in local community health centers and psychosocial assistance centers. This convenience sample included participants who voluntarily sought out the clinic after learning about the study in the media or who were referred by mental health professionals. Patients currently in psychiatric or psychological treatment, at risk of suicide, or who met the criteria for psychoactive substance abuse were excluded from the study.

Of the 917 individuals assessed for inclusion, 665 did not meet the inclusion criteria. Therefore, the final sample consisted of 252 individuals who were randomized between two models of brief psychotherapy: cognitive behavioral therapy or short-term psychodynamic psychotherapy.3131. Luborsky L, Mark D, Hole AV, Popp C, Goldsmith B, Cacciola J. Supportive-expressive dynamic psychotherapy of depression: a time-limited version. Dynamic therapies for psychiatric disorders. New York: Basic Books; 1995. Cognitive behavioral therapy proposes that distorted or dysfunctional thinking, which influences mood and behavior, is common to all psychological disorders.3232. Beck AT, Rush AJ, Shaw BF, Emery G. Terapia cognitiva da depressão (S. Costa, Trad.). Artmed, Porto Alegre; 1997. Short-term psychodynamic psychotherapy followed a protocol based on Luborsky’s theory, providing time-limited supportive expressive dynamic psychotherapy.3131. Luborsky L, Mark D, Hole AV, Popp C, Goldsmith B, Cacciola J. Supportive-expressive dynamic psychotherapy of depression: a time-limited version. Dynamic therapies for psychiatric disorders. New York: Basic Books; 1995. This model analyzes the patient’s central pattern of interpersonal relationships. Both of these techniques are supportive (creating a positive, helpful, and empathic relationship between the therapist and the patient) and expressive (helping the patient express, understand, and change problems).

A researcher uninvolved in the assessment process and the psychotherapeutic interventions performed the randomization, determining which psychotherapy model each participant would be allocated to through a raffle. Thus, the team responsible for the baseline, post-intervention, and 6-month follow-up assessments was blind to the patient’s intervention model. Both interventions included seven weekly 1-hour sessions at the Hospital Universitário São Francisco de Paula, Pelotas, Brazil. Clinically experienced psychologists conducted the psychotherapy sessions. The therapists received 2 months of training in weekly 2-hour meetings, after which they were supervised by two professionals with extensive experience in diagnosing mental disorders.

A previous study using the same clinical trial data determined that, according to biochemical markers, both cognitive behavioral therapy and short-term psychodynamic psychotherapy effectively treat depressive symptoms, regardless of the presence of PD.3333. Alves GDGS. Efetividade terapêutica, personalidade marcadores bioquímicos em dois modelos de psicoterapia breve para depressão [dissertation]. Pelotas: Universidade Católica de Pelotas; 2016. Further evidence suggests that both models of psychotherapy are efficacious for MDD symptoms.3434. Cuijpers P, Berking M, Andersson G, Quigley L, Kleiboer A, Dobson KS. A meta-analysis of cognitive-behavioural therapy for adult depression, alone and in comparison with other treatments. Can J Psychiatry. 2013;58:376-85.,3535. Lopes RT, Gonçalves MM, Machado PP, Sinai D, Bento T, Salgado J. Narrative therapy vs. cognitive-behavioral therapy for moderate depression: empirical evidence from a controlled clinical trial. Psychother Res. 2014;24:662-74. It should also be pointed out that, according to our linear regression analysis (described below), the psychotherapy model was not a confounding factor in determining the effect of defenses on depressive symptoms. Therefore, we grouped the therapy models to increase the statistical power of the variables and the reliability of the data.

A total of 75 individuals were excluded from the study: 10 did not begin treatment, five did not complete the Beck Depression Inventory-II (BDI-II), 42 did not complete the Defense Style Questionnaire (DSQ), and 18 did not complete the Millon Clinical Multiaxial Inventory-III (MCMI-III). A total of 177 participants began treatment, but 58 abandoned it and seven others either presented a risk of suicide during treatment or took psychiatric medications. Thus, 112 participants concluded psychotherapy. A further 12 participants were lost to follow-up due to change of address or telephone. Thus, 100 patients were followed up 6 months after treatment, as shown in Figure 1.

Figure 1
Patient flow chart. BDI = Beck Depression Inventory; CBT = cognitive behavioral therapy; DSQ = Defense Style Questionnaire; MCMI = Millon Clinical Multiaxial Inventory; SEDP = supportive-expressive dynamic psychotherapy.

Measures

The socioeconomic, mood disorder, and PD data were collected at the baseline assessment. We also analyzed the defense mechanism and depressive symptom scores at baseline, post-treatment, and after 6 months of follow-up. The participants were interviewed to collect sociodemographic data (sex, age, education, and race). Economic status was assessed using the Brazilian National Economic Index (ĺndice Nacional de Preços ao Consumidor), which is based on principal component analysis and was used in the 2000 Brazilian census (Censo Demográfico 2000).3636. Associação Brasileira de Empresas de Pesquisa (ABEP). Dados com base no Levantamento Socioeconômico [Internet]. 2021. [Cited by 2021 July 13]. https://www.abep.org/criterio-brasil
https://www.abep.org/criterio-brasil...
This instrument determines a socioeconomic classes based on ownership of certain consumer products and the education level of the head of the household, classifying individuals as A, B, C, D, or E, with A representing the highest and E the lowest level.

MDD was evaluated using the MINI-Plus. According to international criteria, this instrument, a structural diagnostic interview designed for clinical practice,3737. Amorim P. Mini International Neuropsychiatric Interview (MINI): validação de entrevista breve para diagnóstico de transtornos mentais. Braz J Psychiatry. 2000;22:106-15. is an appropriate alternative for patient evaluation in both clinical and epidemiological studies.3737. Amorim P. Mini International Neuropsychiatric Interview (MINI): validação de entrevista breve para diagnóstico de transtornos mentais. Braz J Psychiatry. 2000;22:106-15. The BDI-II , which was used to detect depressive symptoms,3838. Gomes-Oliveira MH, Gorenstein C, Lotufo Neto F, Andrade LH, Wang YP. Validation of the Brazilian Portuguese version of the Beck Depression Inventory-II in a community sample. Braz J Psychiatry. 2012;34:389-94. consists of 21 items that assess the symptom severity in clinical and non-clinical samples. Its cutoff points are: ≤ 27 for mild and moderate symptoms and ≥ 28 for severe symptoms: the higher the score, the greater the depressive symptomatology. This instrument has good validity and reliability coefficients.3838. Gomes-Oliveira MH, Gorenstein C, Lotufo Neto F, Andrade LH, Wang YP. Validation of the Brazilian Portuguese version of the Beck Depression Inventory-II in a community sample. Braz J Psychiatry. 2012;34:389-94. The original instrument demonstrated excellent internal consistency, ranging from 0.91 to 0.93,3939. Sprinkle SD, Lurie D, Insko SL, Atkinson G, Jones GL, Logan AR, et al. Criterion validity, severity cut scores, and test-retest reliability of the Beck Depression Inventory-II in a university counseling center sample. J Couns Psychol. 2002;49:381-5. as did the Brazilian version (α = 0.93).3838. Gomes-Oliveira MH, Gorenstein C, Lotufo Neto F, Andrade LH, Wang YP. Validation of the Brazilian Portuguese version of the Beck Depression Inventory-II in a community sample. Braz J Psychiatry. 2012;34:389-94. Many researchers have used the BDI-II to evaluate samples of outpatients.4040. Wang J, Wu X, Lai W, Long E, Zhang X, Li W, et al. Prevalence of depression and depressive symptoms among outpatients: a systematic review and meta-analysis. BMJ Open. 2017;7:e017173.

41. Nasstasia Y, Baker AL, Lewin TJ, Halpin SA, Hides L, Kelly BJ, et al. Differential treatment effects of an integrated motivational interviewing and exercise intervention on depressive symptom profiles and associated factors: a randomised controlled cross-over trial among youth with major depression. J Affect Disord. 2019;259:413-23.
-4242. Freedland KE, Carney RM, Rich MW, Steinmeyer BC, Rubin EH. Cognitive behavior therapy for depression and self-care in heart failure patients: a randomized clinical trial. JAMA Intern Med. 2015;175:1773-82.

The MCMI-III was used to assess PDs4343. Millon T, Davis R, Millon C. MCMI-III. Manual Millon Clinical Multiaxial Inventory-III. 2nd ed. Minneapolis: National Computer Systems; 1994. according to DSM-IV criteria.88. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR). Arlington: American Psychiatric Publishing; 2000. It consists of 175 statements that the respondent rates as “true” or “false”. MCMI-III scores range from 0 to 115, with ≥ 85 indicating the presence of a PD. The only PD included in this study was cluster B PDs (antisocial, histrionic, narcissistic, and borderline). In the original version, the scale’s internal consistency ranged from 0.66 (compulsive scale) to 0.99 (major depressive disorders).4343. Millon T, Davis R, Millon C. MCMI-III. Manual Millon Clinical Multiaxial Inventory-III. 2nd ed. Minneapolis: National Computer Systems; 1994. In the Brazilian version of the MCMI-III, the Cronbach’s alpha coefficients ranged from 0.54 to 0.87.4444. Magalhaes CL, Magalhaes ES, Noblitt R, Lewis J. Development and reliability of a Brazilian Portuguese version of the MCMI-III. Psychol Rep. 2012;110:991-1001. This instrument has been used in other studies evaluating depression outpatients.4545. Saulsman LM. Depression, anxiety, and the MCMI-III: construct validity and diagnostic efficiency. J Pers Assess. 2011;93:76-83.,4646. Schweitzer I, Tuckwell V, Maguire K, Tiller J. Personality pathology, depression and HPA axis functioning. Hum Psychopharmacol. 2001;16:303-8.

The DSQ, published by Bond et al. in 19834747. Bond M, Vaillant JS, Christian J, Sigal J. Empirical study of self rated defense styles. Archives General of Psychiatry. 1983;40 (3), 333-38., was used to assess defense mechanisms, seeking to identify the characteristic style respondents use to deal with conflict. In 1993 Andrews et al. restructured the instrument into 40 questions based on the defenses described in the DSM-III.4848. Pichot P. [DSM-III: the 3d edition of the Diagnostic and Statistical Manual of Mental Disorders from the American Psychiatric Association]. Rev Neurol (Paris). 1986;142:489-99.,4949. Blaya C, Kipper L, Heldt E, Isolan L, Ceitlin LH, Bond M, et al. [Brazilian-Portuguese version of the Defense Style Questionnaire (DSQ-40) for defense mechanisms measure: a preliminary study]. Braz J Psychiatry. 2004;26:255-8. Four of the defenses are related to the mature factor (sublimation, humor, anticipation, and suppression), four to the neurotic factor (undoing, pseudo-altruism, idealization, and reaction formation), and twelve to the immature factor (projection, passive-aggression, acting-out, isolation, devaluation, “autistic fantasy,” denial, displacement, dissociation, splitting, rationalization, and somatization). Each item is responded on a nine-point Likert scale ranging from 1 (strongly disagree) to 9 (strongly agree): the higher the score, the more predominant the defense mechanism. The scores for each factor are calculated using by the mean scores of the defenses associated with that factor. The Brazilian version of the questionnaire has demonstrated good reliability,5050. Dreher CB. Tradução, adaptação e validação do Defensive Style Questinnaire (DSQ-40) para o português brasileiro [dissertation]. Porto Alegre: Universidade Federal do Rio Grande do Sul; 2005. with Cronbach’s alpha coefficients of 0.68 for the mature style, 0.71 for the neurotic style, and 0.77 for the immature style. Test-retest reliability analysis determined coefficients of 0.68 for the mature style, 0.71 for the neurotic style, and 0.81 for the immature style. For the present study, reliability was estimated in terms of internal consistency, with Cronbach’s alpha results of 0.58 for the mature style, 0.84 for the immature style, and 0.69 for the neurotic style. Other studies with samples of depressed patients have also used this instrument.5151. Perry JC, Banon E, Bond M. Change in defense mechanisms and depression in a pilot study of antidepressive medications plus 20 sessions of psychotherapy for recurrent major depression. J Nerv Ment Dis. 2020;208:261-8.

52. Kramer U, de Roten Y, Perry JC, Despland JN. Change in defense mechanisms and coping patterns during the course of 2-year-long psychotherapy and psychoanalysis for recurrent depression: a pilot study of a randomized controlled trial. J Nerv Ment Dis. 2013;201:614-20.
-5353. Tabakci AS, Yildirim EA, Erkiran M, Aksoy UM, Sahan HE, Tuna O, et al. Temperament, character, and defense mechanism changes with treatment in depression: a 9-month naturalistic follow-up. J Nerv Ment Dis. 2020;208:403-12.

Statistical analysis

After the assessment instruments were applied at baseline, post-intervention, and after 6 months of follow-up, the data were double-entered into Epi-Info 6.04d software, and were subsequently checked for consistency using the VALIDATE command. Statistical analysis was performed using SPSS 22.0. The chi-square test and Student’s t-test were used to evaluate whether the sociodemographic and clinical characteristics of the sample were homogeneously distributed between the intervention models.

Hierarchical linear regression analyses were used to evaluate the association between depressive symptoms and immature defense mechanisms. The following covariates were sequentially entered in each analysis: sex, age, depressive symptoms at baseline, and intervention model. Variables were required not to exceed variance inflation factor values > 10. Outliers were also explored by applying casewise diagnostics (> 3 standard deviations [SD] above or below the mean). We also controlled all significant autocorrelation terms in the initial regression models and examined the Durbin-Watson statistic in the final adjusted models to determine the non-significance of first-order autocorrelation of the regression residuals. Statistical significance was set at p < 0.05.

Ethics statement

The project was approved by the Universidade Católica de Pelotas research ethics committee (#46/2012). All patients were informed about the study objectives by the researchers and provided written informed consent.

Results

Baseline data

The sample consisted of 177 patients diagnosed with MDD. Of these, 77 (39.5%) had cluster B PDs, while the other 100 (51.3%) did not. The mean age was 35.66±11.58 years, the majority were female (81.9%), White (81.4%), and had nine or more years of education (74.6 %). The majority belonged to socioeconomic classes C, D, or E (54.8%) (Table 1).

Table 1
Sociodemographic and clinical characteristics at baseline among depressed patients with and without cluster B PDs (n=177)

There was no significant difference between the intervention models regarding sociodemographic variables, depressive symptoms, or DSQ subscale (p > 0.05). Comparisons at baseline were performed between participants who dropped out and those who continued treatment. No significant differences were found in depressive symptoms, t(75) = 0.772; p = 0.443; DSQ-mature, t(75) = -1.47; p = 0.145; DSQ-neurotic t(75) = 0.24; p = 0.811; and DSQ-immature defense styles t(75) = -0.762; p = 0.449.

Considering the total sample, the mean severity of depressive symptoms was 32.16±10.56, with 11.3% (n=20) of the patients presenting mild depression, 28.2% (n=50) moderate depression, and 60.5% (n=107) severe depression. Regarding defensive styles at baseline, the mean scores were 4.52±1.28 points for mature defenses, 4.64±1.19 for neurotic defenses, and 4.30±0.94 points for immature defenses.

The mean neurotic defense scores among depressed patients with and without cluster B PDs were 4.85±1.11 and 4.48±1.23 points, respectively, which was statistically significant (p = 0.042). Likewise, the mean immature defense score at baseline among patients with and without cluster B PDs were 4.53±0.92 and 4.11±0.93 points, respectively, which was also a significant difference (p = 0.003) (Table 1).

Post-intervention and follow-up data

In the overall sample, pairwise comparison with Bonferroni correction showed significant improvement in depressive symptoms between baseline and post-intervention (mean diff = 12.72; standard error [SE] = 1.79; p < 0.001) and between baseline and the 6-month follow-up assessment (mean diff = 14.80; SE = 1.93; p < 0.001). However, there was no significant difference in depressive symptoms between the post-intervention and the 6-month follow-up assessment (p = 0.811) (data not shown).

There was a significant improvement in DSQ-mature defense style from baseline to post-intervention (mean diff = -0.587; SE = 0.19; p < 0.0013), and from baseline to the 6-month follow-up assessment (mean diff = -0.86; SE = 0.233; p = 0.003) in the overall sample. However, it did not differ significantly between the post-intervention and the 6-month follow-up (p = 0.611) assessments. Moreover, the DSQ-neurotic defense style did not differ significantly between the baseline, post-intervention, and 6-month follow-up (p = 1.000) assessments, nor between the post-intervention and 6-month follow-up (p = 0.928) assessments. Similarly, the DSQ-immature defense style did not differ significantly between the baseline, post-intervention, and 6-month follow-up (p > 0.05) assessments, nor between the post-intervention and 6-month follow-up (p = 1.000) assessments (data not shown).

Table 2 shows the correlation between defense style scores at baseline and depressive symptoms at the post-intervention and 6-month follow-up assessments. Regarding depressed patients without cluster B PDs, no defense style factor showed statistically significant correlation with persistent depressive symptoms after the intervention. However, in depressed patients with cluster B PDs, significant positive correlations were found between immature defenses and persistent depressive symptoms at both the post-intervention (r = 0.505; p < 0.001) and 6-month follow-up assessments (r = 0.54; p < 0.001) (Table 2).

Table 2
Correlation between defense mechanisms at baseline and depressive symptoms at the post-intervention and 6-month follow-up assessment in depressed patients with and without cluster B PDs (n=177)

Figure 2 shows the linear regression between immature defense mechanisms at baseline and depressive symptoms after psychotherapy. At post-intervention, after adjusting for age (β = 0.106; p = 0.472), sex (β = 0.065; p = 0.649), treatment conditions (β = -0.041; p = 0.777), and depressive symptoms at baseline (β = 0.588; p < 0.001), the DSQ-immature defense style at baseline significantly predicted persistent depressive symptoms (adj. r2 = 0.501; β = 0.530; p < 0.001) only in patients with PD. Similarly, at the 6-month follow-up assessment, after adjusting for age (β = -0.010; p = 0.940), sex (β = 0.199; p = 0.115), treatment conditions (β = 0.060; p = 0.635), and depressive symptoms at baseline (β = 0.407; p < 0.001), having a DSQ-immature defense style at baseline also significantly predicted persistent depressive symptoms (adj. r2 = 0.335; β = 0.516; p < 0.001) only in patients with PD.

Figure 2
Linear regression between immature defense mechanisms and depressive symptoms. BDI = Beck Depression Inventory; DSQ = Defense Style Questionnaire.

Discussion

This study sought to expand knowledge about the impact of immature defenses on depression after brief psychotherapies in patients with cluster B PDs. The hypothesis that immature defenses at baseline would be associated with persistent depressive symptoms only in depressed patients with PDs was confirmed, both at the post-intervention and 6-month follow-up assessments, even after adjusting for sociodemographic and clinical characteristics and type of psychotherapy.

Two previous studies that evaluated defenses at baseline as predictors of therapeutic outcome in patients with comorbid PD had conflicting results.3030. Laaksonen MA, Sirkiä C, Knekt P, Lindfors O. Self-reported immature defense style as a predictor of outcome in short-term and long-term psychotherapy. Brain Behav. 2014;4:495-503.,5454. Hersoug AG, Høglend P, Gabbard GO, Lorentzen S. The combined predictive effect of patient characteristics and alliance on long-term dynamic and interpersonal functioning after dynamic psychotherapy. Clin Psychol Psychother. 2013;20:297-307. Unlike our study, Hersoug et al.5454. Hersoug AG, Høglend P, Gabbard GO, Lorentzen S. The combined predictive effect of patient characteristics and alliance on long-term dynamic and interpersonal functioning after dynamic psychotherapy. Clin Psychol Psychother. 2013;20:297-307. found that immature defenses were not associated with poor therapeutic results in patients with comorbid PD. It is assumed that this result was due both to the heterogeneity and limited size of the sample (n=43), as well as the way the defense mechanisms were analyzed, since mature, neurotic, and immature defenses were grouped together without allowing observation of the real impact of immature defenses on treatment response. However, the results of Laaksonen et al.3030. Laaksonen MA, Sirkiä C, Knekt P, Lindfors O. Self-reported immature defense style as a predictor of outcome in short-term and long-term psychotherapy. Brain Behav. 2014;4:495-503. corroborated our findings in that immature defenses at baseline predicted poor response to brief psychotherapy in patients with comorbid PD.

We also found that depressed patients with cluster B PDs used immature defenses significantly more than depressed patients without cluster B PDs. This corroborates a study that observed different defense profiles in depressed patients with comorbidities than in those with depression alone.5555. Yuan Y, Zhang XB, Wu AQ. Defense mechanisms in Chinese patients with comorbid anxiety and depression. J Nerv Ment Dis. 2002;190:265-7. Just as in comorbidities, where the disorders coexist and worsen each other,5656. Gunderson JG, Stout RL, Shea MT, Grilo CM, Markowitz JC, Morey LC, et al. Interactions of borderline personality disorder and mood disorders over 10 years. J Clin Psychiatry. 2014;75:829-34.

57. Young M. Treatment-resistant depression: the importance of identifying and treating co-occurring personality disorders. Psychiatr Clin North Am. 2018;41:249-61.
-5858. Köhling J, Ehrenthal JC, Levy KN, Schauenburg H, Dinger U. Quality and severity of depression in borderline personality disorder: a systematic review and meta-analysis. Clin Psychol Rev. 2015;37:13-25. the immature defenses associated with each comorbid psychopathology can overlap, causing even more suffering and harm to the patient. Cluster B PDs patients make massive use of image-distorting defenses, such as splitting, omnipotence, denial, or externalizing defenses, such as excessive acting out,5959. Perry JC, Presniak MD, Olson TR. Defense mechanisms in schizotypal, borderline, antisocial, and narcissistic personality disorders. Psychiatry. 2013;76:32-52. while patients who have depression use more internalizing defenses, such as passive aggression, isolation, somatization,6060. Waqas A, Rehman A, Malik A, Muhammad U, Khan S, Mahmood N. Association of ego defense mechanisms with academic performance, anxiety and depression in medical students: a mixed methods study. Cureus. 2015;7:e337. and projection.6161. Colovic O, Lecic Tosevski D, Perunicic Mladenovic I, Milosavljevic M, Munjiza A. Defense mechanisms in “pure” anxiety and “pure” depressive disorders. J Nerv Ment Dis. 2016;204:746-51. The coexistence of these defenses may be associated with significantly greater use of immature defenses observed in depressed patients with cluster B PDs in our study, compared to those without PDs.

Thus, the results showed that one of the main factors responsible for the worst therapeutic response of patients with cluster B PDs in our study was this higher predominance of immature defenses, corroborating the initial hypothesis. Several characteristics of the predominant use of primitive defenses may contribute to this worse outcome in brief therapies, considering that immature defenses are related to greater experience distortion with the therapist, greater difficulty in understanding interventions, impairments in therapeutic alliance,2929. Fitzpatrick T. Primitive defenses and unilateral termination of psychotherapy: are the lerner defense scales useful in predicting premature termination in psychotherapy? [dissertation]. Pittsburgh: Duquesne University; 2014.,3030. Laaksonen MA, Sirkiä C, Knekt P, Lindfors O. Self-reported immature defense style as a predictor of outcome in short-term and long-term psychotherapy. Brain Behav. 2014;4:495-503. greater impulsivity, and risk behaviors,1212. Mergui J, Raveh D, Gropp C, Golmard JL, Jaworowski S. Prevalence and characteristics of cluster B personality disorder in a consultation-liaison psychiatry practice. Int J Psychiatry Clin Pract. 2015;19:65-70.,1919. McWilliams N. Psychoanalytic diagnosis: understanding personality structure in the clinical process, 2nd ed. New York: Guilford Press; 2011.,2626. Corruble E, Bronnec M, Falissard B, Hardy P. Defense styles in depressed suicide attempters. Psychiatry Clin Neurosci. 2004;58:285-8. leading to worse adherence to treatment.6262. Akram F, Naz MA. Ego defense mechanisms, medication adherence and self-management of the patients with type 2 diabetes. J Pak Med Assoc. 2021;71:624-8.,6363. Gabbard GO. Psychodynamic psychiatry in clinical practice. 5th ed. Arlington: American Psychiatric Publishing; 2014. In addition, studies show that patients who make predominant use of immature defenses tend to be more resistant to changes,1919. McWilliams N. Psychoanalytic diagnosis: understanding personality structure in the clinical process, 2nd ed. New York: Guilford Press; 2011.,2525. Perry JC, Bond M. Change in defense mechanisms during long-term dynamic psychotherapy and five-year outcome. Am J Psychiatry. 2012;169:916-25.,5454. Hersoug AG, Høglend P, Gabbard GO, Lorentzen S. The combined predictive effect of patient characteristics and alliance on long-term dynamic and interpersonal functioning after dynamic psychotherapy. Clin Psychol Psychother. 2013;20:297-307. demonstrating that long-term therapy can be more effective than short-term therapies.3030. Laaksonen MA, Sirkiä C, Knekt P, Lindfors O. Self-reported immature defense style as a predictor of outcome in short-term and long-term psychotherapy. Brain Behav. 2014;4:495-503. Long-term therapies allow greater adaptive changes in defense mechanisms, which are necessary to achieve improvements in pathological aspects of personality,2525. Perry JC, Bond M. Change in defense mechanisms during long-term dynamic psychotherapy and five-year outcome. Am J Psychiatry. 2012;169:916-25.,6464. Lindfors O, Knekt P, Heinonen E, Härkänen T, Virtala E; Helsinki Psychotherapy Study Group. The effectiveness of short- and long-term psychotherapy on personality functioning during a 5-year follow-up. J Affect Disord. 2015;173:31-8. and therefore, can bring more benefits to patients with cluster B PDs.6464. Lindfors O, Knekt P, Heinonen E, Härkänen T, Virtala E; Helsinki Psychotherapy Study Group. The effectiveness of short- and long-term psychotherapy on personality functioning during a 5-year follow-up. J Affect Disord. 2015;173:31-8.

Furthermore, it is noteworthy that previous research has sought to explain other reasons for the lower remission of depressive symptoms in patients with cluster B. According to Jacob et al.,6565. Jacob CP, Müller J, Schmidt M, Hohenberger K, Gutknecht L, Reif A, et al. Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity. Neuropsychopharmacology. 2005;30:1711-8. cluster B patients have genetic variants that play a significant role in altering the results of mood disorders. These authors investigated an allelic variation of monoamine oxidase A (MAOA) activity, which was associated with the presence of cluster B PDs.6565. Jacob CP, Müller J, Schmidt M, Hohenberger K, Gutknecht L, Reif A, et al. Cluster B personality disorders are associated with allelic variation of monoamine oxidase A activity. Neuropsychopharmacology. 2005;30:1711-8. These biological factors suggest an important difference in how cluster B patients physiologically process stressors and respond to interventions, which may explain the worst therapeutic outcomes of these patients.5757. Young M. Treatment-resistant depression: the importance of identifying and treating co-occurring personality disorders. Psychiatr Clin North Am. 2018;41:249-61. Another explanation is that the childhood traumatic experiences that these patients usually suffer1919. McWilliams N. Psychoanalytic diagnosis: understanding personality structure in the clinical process, 2nd ed. New York: Guilford Press; 2011.,6666. Zhang T, Chow A, Wang L, Dai Y, Xiao Z. Role of childhood traumatic experience in personality disorders in China. Compr Psychiatry. 2012;53:829-36. can lead to impairments in therapeutic alliance and therefore, on the treatment outcomes.1919. McWilliams N. Psychoanalytic diagnosis: understanding personality structure in the clinical process, 2nd ed. New York: Guilford Press; 2011.,6767. Baier AL, Kline AC, Feeny NC. Therapeutic alliance as a mediator of change: a systematic review and evaluation of research. Clin Psychol Rev. 2020;82:101921.,6868. Bender DS. The therapeutic alliance in the treatment of personality disorders. J Psychiatr Pract. 2005;11:73-87. Complementing as previous findings, other studies suggest that cluster B patients exhibit interpersonal chronic stress,6969. Daley SE, Hammen C, Burge D, Davila J, Paley B, Lindberg N, et al. Depression and Axis II symptomatology in an adolescent community sample: concurrent and longitudinal associations. J Pers Disord. 1999;13:47-59. which in turn has been associated with greater severity of depressive symptoms.6969. Daley SE, Hammen C, Burge D, Davila J, Paley B, Lindberg N, et al. Depression and Axis II symptomatology in an adolescent community sample: concurrent and longitudinal associations. J Pers Disord. 1999;13:47-59. Thus, the present study reveals a new possibility: the immature defenses of depressed patients with cluster B PDs as predictors of low reduction of depressive symptoms.

Regarding the depressed patients without PD, the studies that have evaluated the defense mechanisms as predictors of therapeutic response7070. Kronström K, Salminen JK, Hietala J, Kajander J, Vahlberg T, Markkula J, et al. Does defense style or psychological mindedness predict treatement response in major depression? Depress Anxiety. 2009;26:689-95.,7171. Van Henricus L, Dekker J, Peen J, Abraham RE, Schoevers R. Predictive value of self-reported and observer-rated defense style in depression treatment. Am J Psychother. 2009;63:25-39. showed results that corroborate those obtained in our study. Interestingly, in the studies by Kronström & Salminen,7070. Kronström K, Salminen JK, Hietala J, Kajander J, Vahlberg T, Markkula J, et al. Does defense style or psychological mindedness predict treatement response in major depression? Depress Anxiety. 2009;26:689-95. which included patients with mild MDD, in those by Van Henricus & Dekker,7171. Van Henricus L, Dekker J, Peen J, Abraham RE, Schoevers R. Predictive value of self-reported and observer-rated defense style in depression treatment. Am J Psychother. 2009;63:25-39. with moderate MDD, as well as in our study, which treated patients with severe MDD, the immature defenses were not predictors of worse therapeutic outcomes in patients with MDD. One explanation for this finding is that a lower use of immature defenses observed in depressed patients without PD may be more flexible to the adaptive changes that occur during treatment,2525. Perry JC, Bond M. Change in defense mechanisms during long-term dynamic psychotherapy and five-year outcome. Am J Psychiatry. 2012;169:916-25.,7272. Babl A, Berger T, Grosse Holtforth M, Taubner S, Caspar F, Gómez Penedo JM. Disentangling within- and between-patient effects of defensive functioning on psychotherapy outcome using mixed models. Psychother Res. 2020;30:1088-100. causing a decrease in the impact of immature defenses at baseline and enabling better therapeutic response. This finding may be one of the reasons that clarify the best therapeutic outcome of depressed patients without PD compared to those with PD, as observed in a meta-analysis.99. Newton-Howes G, Tyrer P, Johnson T, Mulder R, Kool S, Dekker J, et al. Influence of personality on the outcome of treatment in depression: systematic review and meta-analysis. J Pers Disord. 2014;28:577-93.

It is noteworthy that in studies that evaluated defenses as predictors of therapeutic outcomes,3030. Laaksonen MA, Sirkiä C, Knekt P, Lindfors O. Self-reported immature defense style as a predictor of outcome in short-term and long-term psychotherapy. Brain Behav. 2014;4:495-503.,5454. Hersoug AG, Høglend P, Gabbard GO, Lorentzen S. The combined predictive effect of patient characteristics and alliance on long-term dynamic and interpersonal functioning after dynamic psychotherapy. Clin Psychol Psychother. 2013;20:297-307.,7070. Kronström K, Salminen JK, Hietala J, Kajander J, Vahlberg T, Markkula J, et al. Does defense style or psychological mindedness predict treatement response in major depression? Depress Anxiety. 2009;26:689-95.,7171. Van Henricus L, Dekker J, Peen J, Abraham RE, Schoevers R. Predictive value of self-reported and observer-rated defense style in depression treatment. Am J Psychother. 2009;63:25-39. groups of depressed patients with PD were not evaluated compared to groups of depressed individuals without PD, especially the cluster B was not evaluated separately. It is known that there is an uneven effect of the defenses in each psychopathology,7373. Blaya C, Dornelles M, Blaya R, Kipper L, Heldt E, Isolan L, et al. Do defense mechanisms vary according to the psychiatric disorder? Braz J Psychiatry. 2006;28:179-83. and therefore it is necessary to evaluate them separately in each group of disorders. Nowadays, many disorders are defined according to their defenses.6363. Gabbard GO. Psychodynamic psychiatry in clinical practice. 5th ed. Arlington: American Psychiatric Publishing; 2014. Thus, the present study was the first to analyze immature defenses as predictors of therapeutic outcome in a group of depressed patients with cluster B PDs, compared to depressed patients without cluster B PDs.

Some limitations should be considered in understanding the results of the present study. First, the impact of the immature defenses of patients with cluster B PDs on the outcome of long-term therapies has not been analyzed. Therefore, it is not known to what extent the immature defenses may also be considered predictors of outcomes in long-term therapies with these patients. Another limitation is that the convenience sample in our study, which did not allow generalizing of these results to patients without MDD. However, this feature can be considered a strong point in our findings, since it is valid for patients with MDD, as well as for those with comorbid PD. Another strong point is related to the methodology, as it is nested within randomized clinical trial. In addition, the assessments have been made by professionals trained for this purpose, giving high validity to the diagnostic process.

In conclusion, some points should be considered: first, a significantly higher predominance of immature defenses was observed in depressed patients with cluster B PDs compared to depressed patients without cluster B PDs. Second, in patients diagnosed with depression without cluster B PDs, the immature defenses were not predictors of worse therapeutic outcomes. Finally, only in depressed patients with cluster B PDs the immature defenses were significant predictors of worse therapeutic response in terms of persistence of depressive symptoms at post-intervention and 6-month follow-up. These findings suggest the importance of assessing immature defenses at baseline to assist in the identification of patients who are at greater risk of having a worse therapeutic outcome, allowing for the choice of more appropriate interventions, and avoiding ineffective treatments. Thus, further studies are needed to corroborate our findings on the negative impact of immature defenses of depressed patients with cluster B PDs on the response to brief therapies. Other studies that analyze the effect of the immature defenses of these patients with cluster B PDs on long-term therapies may also be relevant.

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Publication Dates

  • Publication in this collection
    15 July 2022
  • Date of issue
    Sep-Oct 2022

History

  • Received
    30 Aug 2021
  • Accepted
    18 Jan 2022
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