Gastro protective activity of the Pavonia alnifolia A.St.-Hil. extract.

B.T. EWALD C.M. LOYOLLA A.C.H. PEREIRA D. LENZ A.R.S MEDEIROS T.U. ANDRADE B.V. NOGUEIRA T.M.C. PEREIRA D.C. ENDRINGER About the authors

ABSTRACT

In Brazil, the Malvaceae family is represented by at about 200 species. Some of those species are known as gastro protective ones. The Pavonia alnifolia A.St.-Hil (Malvaceae) was selected after a chemosystematic approach. The gastro preventive activity of the ethanol extract of stems Pavonia alnifolia was evaluated through the use of the Ethanol:chlroridric acid model on mice. The quantification of the total flavonoids (aluminum chloride method) and total polyphenols (Folin-Ciocalteu method) was also performed since the relation of those components with gastric protection has been previously highlighted. The tests showed a significant reduction of the ulcer formation in the mice treated with the plant extract (10, 100 and 300 mg/kg). This effect may be related to the presence of polyphenols whose content was found to be 74.3 ± 7.5 μg/mg of vegetal material and 82.7 ± 7.1 μg/mg of crude extract and flavonoids, which in turn showed a content of 17.1 ± 1.4 μg/mg dry extract.

Keywords
Pavonia; Malvaceae; antiulcerogenic; flavonoids; polyphenols

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