ABSTRACT
The aim of this study was to analyze the effect of pequi oil in the healing process of skin lesions in rats. The research was initiated after the ordeal of CEUA- FACID with protocol No. 005/12 and following the ethical principles of animal experimentation according to the Federal Law No. 11,794 / 2008. 20 Wistar rats were used (Rattus norvegicus), with body weight ranging from 300-350g. They were randomly divided into two groups: GI control (C) and GII treated with pequi oil (T). Each group was divided into two subgroups of five animals each, according to the experimental study of 7 days (A) and 14 (B) days. After anesthesia and antisepsis, a circular wound of 2.5 cm of diameter was surgically inflicted in the lumbar dorsal region of the animal. The animals in Group II were treated with daily topical application of 1 ml of pequi oil, respecting the described experimental times. Concomitantly with the measurement of the injury area, the rats were euthanized so that a histological processing and a regression analysis of the percentage of injuries could be performed. In GII, at different experimental times of 7 and 14 days, there were a higher percentage of lesions regression compared to GI (p <0.05). From the histological examination it was possible to detect that, at GII, there were a lower number of inflammatory cells and increased number of fibroblasts compared to IM at different time of the trial (P <0.001). It is concluded that the use of pequi oil presented positive influence on the healing process of skin lesions in rats by promoting quicker tissue repair, as indicated by the faster closure of the wounds and the observation of reduced inflammatory characteristics in the group treated compared to the control group, suggesting that the inflammation could have already receded in the treated group.
Keywords
Caryocar brasiliense; Wounds; Inflammation; Healing
