IL-10 |
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Esclerose Sistêmica |
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(-)1082G/A; (-)819C/T; (-)592C/A |
associação do haplótipo GCC com a forma difusa
(OR=1,84; P=0,04) |
161 |
94 |
Beretta et al. 20073636 Beretta L, Bertolotti F, Cappiello F, Barili M, Masciocchi M, Toussoun K
et al. Interleukin-1 gene complex polymorphisms in systemic sclerosis patients with
severe restrictive lung physiology. Hum Immunol. 2007;68:603-9.
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genótipo GCC/GCC (OR=1,87; P=0,019) |
151 |
147 |
Salim et al. 20134848 Kato H, Tsuchiya N, Tokunaga K. Single nucleotide polymorphisms in the
coding regions of human CXCchemokine receptors CXCR1, CXCR2 and CXCR3. Genes and
Immunity. 2000;1:330-337.
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proteção do genótipo GCC/GCC com a forma difusa
(OR=0,10; P=0,005) |
51 |
94 |
Crilly et al. 20033434 Crilly A, Hamilton J, Clark CJ, Jardine A, Madhok R. Analysis of the 5'
flanking region of the interleukin 10 gene in patients with systemic sclerosis.
Rheumatology (Oxford). 2003;42:1295-8.
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associação do genótipo GCC/GCC (OR=5,07; P=0,002) |
45 |
150 |
Ates et al. 20085757 Ates O, Müsellim B, Ongen G, Topal-Sarikaya A. Association between
'interleukin' 10 gene (IL10) polymorphisms and systemic sclerosis with interstitial
lung involvement. Rheumatol Int. 2008;28:1123-6.
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Peng et al 20125858 Peng WJ, Wang BX, Pan HF, Tao JH, Zhang JQ, He Q et al. Association of
the interleukin-10 1082G/A, 819C/T and 3575T/A gene polymorphisms with systemic
sclerosis: a meta-analysis. Mol Biol Rep. 2012;39:6851-5.
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(-)590 A/C |
sem associação |
242 |
242 |
Beretta et al. 20085959 Beretta L, Cappiello F, Barili M, Scorza R. Proximal interleukin-10 gene
polymorphisms in Italian patients with systemic sclerosis. Tissue Antigens.
2007;69:305-12.
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(-)3575 A/T |
associação do haplótipo AA com a forma limitada
(OR=3,60; P=0,0002) |
105 |
143 |
Hudson et al. 20 056060 Hudson LL, Rocca KM, Kuwana M, Pandey JP. Interleukin-10 genotypes are
associated with systemic sclerosis and influence disease-associated autoimmune
responses .Genes and Immunity. 2005;6:274-278.
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sem associação |
78 |
692 |
Matuzzi et al. 20073333 Mattuzzi S, Barbi S, Carletto A, Ravagnani V, Moore PS, Bambara LM et
al. Association of polymorphisms in the IL1B and IL2 genes with susceptibility and
severity of systemic sclerosis. J Rheumatol. 2007;34:997-1004.
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(-)2849 A/G |
associação do haplótipo GG com a forma limitada
(OR=0,53; P=0,03) |
105 |
143 |
Hudson et al. 20 056060 Hudson LL, Rocca KM, Kuwana M, Pandey JP. Interleukin-10 genotypes are
associated with systemic sclerosis and influence disease-associated autoimmune
responses .Genes and Immunity. 2005;6:274-278.
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(-)2763 A/C |
associação do haplótipo AA com a forma limitada
(OR=3,50; P=0,003) e a forma difusa (OR=3,0; P=0,03) |
105 |
143 |
Hudson et al. 20056060 Hudson LL, Rocca KM, Kuwana M, Pandey JP. Interleukin-10 genotypes are
associated with systemic sclerosis and influence disease-associated autoimmune
responses .Genes and Immunity. 2005;6:274-278.
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Artrite Reumatoide |
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(-)1082G/A; (-)819C/T; (-)592C/A |
associação do haplótipo GCC (OR=1,46; P=0,006) e ACC
(OR=1,43; P=0,011) |
98 |
122 |
Ates et al. 20085757 Ates O, Müsellim B, Ongen G, Topal-Sarikaya A. Association between
'interleukin' 10 gene (IL10) polymorphisms and systemic sclerosis with interstitial
lung involvement. Rheumatol Int. 2008;28:1123-6.
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associação do haplótipo ACC em pacientes positivos
para fator reumatoide IgA (OR=1,6; P=0,05) |
234 |
238 |
Hajeer et al. 19986161 Hajeer AH, Lazarus M, Turner D, Mageed RA, Vencovsky J, Sinnott P et al.
IL-10 gene promoter polymorphisms in rheumatoid arthritis. Scand J Rheumatol.
1998;27:142-5.
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associação do genótipo GCC/GCC (OR=2,18;
P<0,005) |
95 |
104 |
Pawlik et al. 20056262 Pawlik A, Kurzawski M, Szklarz BG, Herczynska M, Drozdzik M.
Interleukin-10 promoter polymorphism in patients with rheumatoid arthritis. Clin
Rheumatol 2005;24:480-484.
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sem associação |
222 |
398 |
Gambhir et al. 20106363 Gambhir D, Lawrence A, Aggarwal A, Misra R, Mandal SK, Naik S.
Association of tumor necrosis factor alpha and IL-10 promoter polymorphisms with
rheumatoid arthritis in North Indian population. Rheumatol Int.
2010;30:1211-1217.
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(-)1087G/A; (-)824C/T; (-)597C/A |
haplótipo ATA associado com baixa produção de IL-10
(P<0,05) |
84 |
95 |
Hee et al. 20076464 Hee CS, Gun SC, Naidu R, Gupta E, Somnath SD, Radhakrishnan AK.
Comparison of single nucleotide polymorphisms in the human interleukin-10 gene
promoter between rheumatoid arthritis patients and normal subjects in Malaysia. Mod
Rheumatol. 2007;17:429-35.
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(-)2849 G/A |
associação do alelo G em pacientes positivos para
fator reumatoide IgG (P<0,001) |
283 |
1220 |
Lard et al. 20036565 Lard LR, van Gaalen FA, Schonkeren JJ, Pieterman EJ, Stoeken G, Vos K,
Nelissen RG, Westendorp RG et al. Association of the -2849 interleukin-10 promoter
polymorphism with autoantibody production and joint destruction in rheumatoid
arthritis. Arthritis Rheum. 2003;48:1841-8.
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(-)1082 G/A |
sem associação (rs1800896) |
376 |
463 |
Emonts et al. 20114343 Emonts M, Hazes MJ, Houwing-Duistermaat JJ, van der Gaastde Jongh CE, de
Vogel L, Han HK et al. Polymorphisms in genes controlling inflammation and tissue
repair in rheumatoid arthritis: a case control study. BMC Med Genet.
2011;7:12-36.
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sem associação |
108 |
128 |
Cantagrel et al. 19996666 Cantagrel A, Navaux F, Loubet-Lescoulié P, Nourhashemi F, Enault G,
Abbal M et al. Interleukin-1beta, interleukin-1 receptor antagonist, interleukin-4,
and interleukin-10 gene polymorphisms: relationship to occurrence and severity of
rheumatoid arthritis. Arthritis Rheum. 1999;42:1093-100.
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proteção com o genótipo AA (OR=0,56; P=0,006) |
162 |
373 |
de Paz et al. 20106767 de Paz B, Alperi-López M, Ballina-García FJ, Prado C, Mozo L, Gutiérrez
C et al. Interleukin 10 and tumor necrosis factor-alpha genotypes in rheumatoid
arthritis-association with clinical response to glucocorticoids. J Rheumatol.
2010;37:503-11.
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(-)819 C/T |
sem associação (rs3021097) |
376 |
463 |
Emonts et al. 20114343 Emonts M, Hazes MJ, Houwing-Duistermaat JJ, van der Gaastde Jongh CE, de
Vogel L, Han HK et al. Polymorphisms in genes controlling inflammation and tissue
repair in rheumatoid arthritis: a case control study. BMC Med Genet.
2011;7:12-36.
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(-)592 C/A |
associação do alelo A (OR=1,31; P=0,008) |
164 |
196 |
Ying et al. 20116868 Ying B, Shi Y, Pan X, Song X, Huang Z, Niu Q, Cai B, Wang L. Association
of polymorphisms in the human IL-10 and IL- 18 genes with rheumatoid arthritis. Mol
Biol Rep. 2011;38:379-385.
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associação do genótipo CA (OR=46,34; P<0001) |
244 |
106 |
Paradowska-Gorycka et al. 20096969 Paradowska-Gorycka A, Trefler J, Maciejewska-Stelmach J, Lacki JK.
Interleukin-10 gene promoter polymorphism in Polish rheumatoid arthritis patients.
Int J Immunogenet. 2010;37:225- 231.
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