Women with cancer and COVID-19: an analysis of lethality and clinical aspects in Pernambuco

Galindo, Rafaella Joanna da Silva Caseca; Andrade, Lívia Barboza de; Sena, Gabrielle Ribeiro; Nogueira, Lídier Roberta Moraes; Lima, Tiago Pessoa Ferreira de; Lima, Jurema Telles Oliveira; Orange, Flávia Augusta

doi:10.1590/1806-9304202100S100008

Rafaella Joanna da Silva Caseca Galindo

Faculdade Pernambucana de Saúde. Av. Mascarenhas de Moraes, 4861 - Imbiribeira. Recife, PE, Brasil. CEP: 51.200-060. E-mail: rafaella.caseca@gmail.com

https://orcid.org/0000-0003-3460-477X

Lívia Barboza de Andrade

Instituto de Medicina Integral Prof. Fernando Figueira. Recife, PE, Brasil.

https://orcid.org/0000-0002-5647-1835

Gabrielle Ribeiro Sena

Instituto de Medicina Integral Prof. Fernando Figueira. Recife, PE, Brasil.

https://orcid.org/0000-0002-8430-3599

Lídier Roberta Moraes Nogueira

Faculdade Pernambucana de Saúde. Av. Mascarenhas de Moraes, 4861 - Imbiribeira. Recife, PE, Brasil. CEP: 51.200-060. E-mail: rafaella.caseca@gmail.com

https://orcid.org/0000-0002-4619-8580

Tiago Pessoa Ferreira de Lima

Faculdade Pernambucana de Saúde. Av. Mascarenhas de Moraes, 4861 - Imbiribeira. Recife, PE, Brasil. CEP: 51.200-060. E-mail: rafaella.caseca@gmail.com

https://orcid.org/0000-0002-1148-4288

Jurema Telles Oliveira Lima

Instituto de Medicina Integral Prof. Fernando Figueira. Recife, PE, Brasil.

https://orcid.org/0000-0003-2671-3570

Flávia Augusta Orange

Faculdade Pernambucana de Saúde. Av. Mascarenhas de Moraes, 4861 - Imbiribeira. Recife, PE, Brasil. CEP: 51.200-060. E-mail: rafaella.caseca@gmail.com

https://orcid.org/0000-0003-0528-4164

Authors’ contribution

Galindo RJSC, Nogueira LRM, Sena GR and Andrade LB: Conception and planning of the study. Lima TPF, Lima JTO and Orange FA: revision of the manuscript. All authors approved the final version of the article

GERES	Total		Death		Location of hospitalization								Location of death
	Total		Death		Public		Private		Non-informed		Public		Private		Home		Non- informed
	N	%	N	%	n	%	n	%	n	%	n	%	n	%	n	%	n	%
I - Recife	44	64.71	34	69.39	25	36.76	11	16.18	8	11.76	20	40.82	7	14.29	1	2.04	6	12.24
II - Limoeiro	6	8.82	4	8.16	3	4.41	2	2.94	1	1.47	2	4.08	2	4.08	0	-	0	-
III - Palmares	1	1.47	1	2.04)	0	-	1	1.47	0	-	1	2.04	1	2.04	0	-	0	-
IV- Caruaru	4	5.88	2	4.08	1	1.47	2	2.94	1	1.47	4	8.16	-		0	-	1	2.04
IX - Ouricuri	5	7.35	5	10.2	4	5.88	1	1.47	0	-	1	2.04	1	2.04	0	-	0	-
VII - Salgueiro	1	1.47	0	-	1	1.47	0	-	0	-	-		0	-	0	-	0	-
X - Afogados da Ingazeira	3	4.41	1	2.04	3	4.41	0	-	0	-	1	2.04	0	-	0	-	0	-
XII - Goiana	2	2.94	1	2.04	2	2.94	0	-	0	-	1	2.04	0	-	0	-	0	-
Other State	2	2.94	1	2.04	2	2.94	0	-	0	-	0	-	0	-	0	-	0	-

Age group (years)	Mean of days between first symptom and death	Mortality
Age group (years)	Mean of days between first symptom and death	n	%
0 - 19	6 ± 0.00	1	33.33
20 - 49	10 ± 5.53	7	43.75
50 - 59	19.11 ± 19.29	9	81.82
60 - 69	11.84 ± 5.98	13	76.47
70 - 79	11.77 ± 8.36	9	90.00
> 80	9.6 ± 4.72	10	90.91

Variables	Cases
	Total		Deaths
	N	%	N	%
	68	100.0	49	100.0
Signs and Symptoms
Fever	48	70.59	36	73.47
Cough	40	58.82	27	55.10
Dyspnea	39	57.35	32	65.31
Saturation of SpÜ2< 95%	33	48.53	29)	59.18
Sore throat	11	16.18	8	16.33
Nausea/ Vomit	7	10.29	6	12.24
Coryza/ Nasal Congestion	5	7.35	1	2.04
Diarrhea	4	5.88	4	8.16
Headache	3	4.41	1	2.04
Myalgia	3	4.41	0	-
Anosmya/ Hyposmia or Ageusia	1	1.47	1	2.04
Tiredness/ Fatigue	1	1.47	1	2.04
Number of comorbidities
1	18	26.47	16	32.65
2	6	8.82	4	8.16
3	3	4.41	2	4.08
Non-informed	41	60.29	27	55.10
Comorbidities
Cardiovascular diseases	19	27.94	16	32.65
Diabetes	9	13.24	7	14.29
Chronic respiratory disease	6	8.82	5	10.20
Chronic kidney disease	2	2.94	1	2.04
Overweight/ obesity	1	1.47	0	-
Chromosomal disorders	1	1.47	1	2.04

Variables	Deaths				Bivariate Analysis			Multivariate Analysis
	Yes		No		OR	CI95%	p	OR	CI95%	p
	n	%	n	%	OR	CI95%	p	OR	CI95%	p
Symptom
Fever	34	70.83	14	29.17	0.89	0.35 - 2.23	0.81	-	-	-
Cough	27	67.50	13	32.50	1.13	0.50 - 2.54	0.76	-	-	-
Saturation O₂< 95%	29	87.88	4	12.12	0.17	0.05 - 0.60	0.005	0.21	0.04 - 0.92	0.039
Age (years)
<19	1	33.33	2	66.67	5.64	0.48 -66.31	0.168	9.81	0.58 - 164.35	0.112
20 - 49	7	43.75	9	56.25	5.40	1.61 - 18.01	0.006	2.52	0.54 - 11.56	0.234
50 - 59	9	81.82	2	18.18	0.52	0.10 -2.68	0.437	-	-	-
60 - 69	13	76.47	4	23.53	0.73	0.20 -2.63	0.640	-	-	-
70 - 79	9	90.00	1	10.00	0.24	0.9 - 2.09	0.200	0.49	0.04 - 5.23	0.556
>80	10	90.91	1	9.09	0.21	0.02 - 1.82	0.159	0.37	0.03 - 3.84	0.410
Comorbidities
Yes	18	24 .3	56	75.7	2.27	0.71 - 7.30	0.166	1.24	0.29 - 5.32	0.768

Variables	Deaths				Bivariate Analysis			Multivariate Analysis
	Yes		No		OR	CI95%	p	OR	CI95%	p
	n	%	n	%	OR	CI95%	p	OR	CI95%	p
Symtom
Fever	34	70.83	14	29.17	0.89	0.35 -2.23	0.81	-	-	-
Cough	27	67.50	13	32.50	1.13	0.50-2.54	0.76	-	-	-
Saturation O₂ < 95%	29	87.88	4	12.12	0.17	0.05 -0.60	0.005	0.21	0.04-0.92	0.039
Age (yeas)
≤19	1	33.33	2	66.67	5.64	0.48-66.31	0.168	9.81	0.58 - 164.35	0.112
20-49	7	43.75	9	56.25	5.40	1.61 - 18.01	0.006	2.52	0.54- 11.56	0.234
50- 59	9	81.82	2	18.18	0.52	0.10-2.68	0.437	-	-	-
60-69	13	76.47	4	23.53	0.73	0.20-2.63	0.640	-	-	-
70-79	9	90.00	1	10.00	0.24	0.29 -2.09	0.200	0.49	0.04-5.23	0.556
≥80	10	90.91	1	9.09	0.21	0.02 - 1.82	0.159	0.37	0.03 -3.84	0.410
Comorbidities
Yes	18	24 .3	56	75.7	2.27	0.71 -7.30	0.166	1.24	0.29 -5.32	0.768

Variables	Deaths				Bivariate Analysis			Multivariate Analysis
	Yes		No		OR	CI95%	p	OR	CI95%	p
	n	%	n	%	OR	CI95%	p	OR	CI95%	p
Signs and symtoms	18	24 .3	56	75.7	2.27	0.71 -7.30	0.166	1.24	0.29 -5.32	0.768
Fever	34	70.83	14	29.17	1.12	0.45-2.79	0.811	-	-	-
Cough	27	69.23	12	30.77	0.88	0.39-1.99	0.765	-	-	-
Saturation O₂ ≤ 95%	29	87.88	4	12.12	5.73	1.65-19.86	0.006	4.74	1.12-20.08	0.035
Age (years)
≤ 19	1	33.33	2	66.67	0.18	0.02-2.08	0.168	0.07	0.00-1.01	0.051
20-49	7	43.75	9	56.25	0.18	0.06-0.62	0.006	0.27	0.07-1.04	0.057
50-59	9	81.82	2	18.18	1.91	0.37-9.80	0.437	-	-	-
60-69	13	76.47	4	23.53	1.35	0.38-4.83	0.640	-	-	-
70-79	9	90.00	1	10.00	4,05	0.48-34.41	0.200	-	-	-
≥ 80	10	90.10	1	9.09	4.62	0.55-38.8	0.159	-	-	-
Comorbidities
Yes	22	81.48	5	18.52	2.28	0.71-7.32	0.166	-	-	-

[1] Authors’ contribution

Galindo RJSC, Nogueira LRM, Sena GR and Andrade LB: Conception and planning of the study. Lima TPF, Lima JTO and Orange FA: revision of the manuscript. All authors approved the final version of the article