Blood flow/pump rotation ratio as an artificial lung performance monitoring tool during extracorporeal respiratory support using centrifugal pumps

ABSTRACT

Objective:

To analyze the correlations of the blood flow/pump rotation ratio and the transmembrane pressure, CO₂ and O₂ transfer during the extracorporeal respiratory support.

Methods:

Five animals were instrumented and submitted to extracorporeal membrane oxygenation in a five-step protocol, including abdominal sepsis and lung injury.

Results:

This study showed that blood flow/pump rotations ratio variations are dependent on extracorporeal membrane oxygenation blood flow in a positive logarithmic fashion. Blood flow/pump rotation ratio variations are negatively associated with transmembrane pressure (R² = 0.5 for blood flow = 1500mL/minute and R² = 0.4 for blood flow = 3500mL/minute, both with p < 0.001) and positively associated with CO₂ transfer variations (R² = 0.2 for sweep gas flow ≤ 6L/minute, p < 0.001, and R² = 0.1 for sweep gas flow > 6L/minute, p = 0.006), and the blood flow/pump rotation ratio is not associated with O₂ transfer variations (R² = 0.01 for blood flow = 1500mL/minute, p = 0.19, and R² = - 0.01 for blood flow = 3500 mL/minute, p = 0.46).

Conclusion:

Blood flow/pump rotation ratio variation is negatively associated with transmembrane pressure and positively associated with CO₂ transfer in this animal model. According to the clinical situation, a decrease in the blood flow/pump rotation ratio can indicate artificial lung dysfunction without the occurrence of hypoxemia.

Objetivo: Analisar as correlações da taxa de fluxo sanguíneo e rotação da bomba com a pressão transmembrana e a transferência de CO₂ e O₂ durante o suporte respiratório extracorpóreo.

Acute respiratory distress syndrome; Respiration, artificial; Extracorporeal membrane oxygenation; Multiple organ failure; Swine